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CLTC Antibody (Center) Blocking Peptide

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS9225846

Clathrin is the major protein of the polyhedral coat of coated pits and vesicles. Two different adapter protein complexes link the clathrin lattice either to the plasma membrane or to the trans-Golgi network. More details

$455 / 0.5 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
CLTC, Blocking Peptide
Full Product Name
CLTC Antibody (Center) Blocking peptide
Product Gene Name
CLTC blocking peptide
Product Synonym Gene Name
CLH17; CLTCL2; KIAA0034
Product Synonym Names
Clathrin heavy chain 1; Clathrin heavy chain on chromosome 17; CLH-17; CLTC; CLH17; CLTCL2; KIAA0034
Form/Format
Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
Preparation and Storage
Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.
Antibody/Peptide Pairs
CLTC peptide (MBS9225846) is used for blocking the activity of CLTC antibody (MBS9210363)
Molecular Weight
187,890 Da
OMIM
118955
Cellular Location
Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Membrane, coated pit; Peripheral membrane protein; Cytoplasmic side. Melanosome. Note: Cytoplasmic face of coated pits and vesicles. Identified by mass spectrometry in melanosome fractions from stage I to stage IV

Other Notes

Small volumes of CLTC blocking peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CLTC purchase

MBS9225846 is a blocking peptide targeting CLTC. Also known as CLTC Antibody (Center) Blocking peptide.

Additional Details

NCBI/Uniprot data below describe general gene information for CLTC. It may not necessarily be applicable to this product.

NCBI GI #
4758012
NCBI GeneID
1213
NCBI Accession #
NP_004850.1
UniProt Primary Accession #
Q00610
UniProt Secondary Accession #
Q6N0A0; Q86TF2; D3DU00
UniProt Related Accession #
Q00610
GenBank Nucleotide #
NM_004859.3
NCBI Official Full Name
clathrin heavy chain 1 isoform 1
NCBI Official Synonym Full Names
clathrin heavy chain
NCBI Official Symbol
CLTC
NCBI Official Synonym Symbols
Hc; CHC; CHC17; CLH-17; CLTCL2
UniProt Protein Name
Clathrin heavy chain 1
UniProt Synonym Protein Names
Clathrin heavy chain on chromosome 17; CLH-17
Protein Family
Clathrin
UniProt Gene Name
CLTC
UniProt Synonym Gene Names
CLH17; CLTCL2; KIAA0034; CLH-17
UniProt Entry Name
CLH1_HUMAN
NCBI Protein Information
clathrin heavy chain 1

NCBI Summary for CLTC

Clathrin is a major protein component of the cytoplasmic face of intracellular organelles, called coated vesicles and coated pits. These specialized organelles are involved in the intracellular trafficking of receptors and endocytosis of a variety of macromolecules. The basic subunit of the clathrin coat is composed of three heavy chains and three light chains. [provided by RefSeq, Jul 2008]
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UniProt Comments for CLTC

CLTC: a major protein component of the cytoplasmic face of coated vesicles and coated pits. The basic subunit of the clathrin coat is composed of three heavy chains and three light chains.

Protein type: Motility/polarity/chemotaxis; Vesicle

Chromosomal Location of Human Ortholog: 17q23.1

Cellular Component: clathrin-coated vesicle; cytosol; focal adhesion; intracellular membrane-bound organelle; membrane; plasma membrane; protein complex; spindle; trans-Golgi network membrane

Molecular Function: clathrin light chain binding; double-stranded RNA binding; protein binding; protein kinase binding

Biological Process: antigen processing and presentation of exogenous peptide antigen via MHC class II; mitosis; osteoblast differentiation; receptor internalization; receptor-mediated endocytosis; retrograde transport, endosome to Golgi; transferrin transport; Wnt receptor signaling pathway, planar cell polarity pathway
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Research Articles on CLTC

1. SMAP2 immunoprecipitated clathrin and AP-1 through a putative clathrin-binding domain and a CALM-binding domain, and SMAP2 mutants that did not interact with clathrin or AP-1 could not localize to recycling endosomes

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with CLTC blocking peptide

 Reference Product  PubMed Publications
 CLTA blocking peptide  >3 publications with CLTC and CLTA
 CLTB blocking peptide  >2 publications with CLTC and CLTB

Pathways associated with CLTC blocking peptide

 Products by Pathway  Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Arf6 Trafficking Events Pathway antibodies  Arf6 Trafficking Events Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 Bacterial Invasion Of Epithelial Cells Pathway antibodies  Bacterial Invasion Of Epithelial Cells Pathway Diagram
 Bacterial Invasion Of Epithelial Cells Pathway antibodies  Bacterial Invasion Of Epithelial Cells Pathway Diagram
 Beta-catenin Independent WNT Signaling Pathway antibodies  Beta-catenin Independent WNT Signaling Pathway Diagram
 Clathrin Derived Vesicle Budding Pathway antibodies  Clathrin Derived Vesicle Budding Pathway Diagram
 Developmental Biology Pathway antibodies  Developmental Biology Pathway Diagram
 EPH-Ephrin Signaling Pathway antibodies  EPH-Ephrin Signaling Pathway Diagram
 EPH-ephrin Mediated Repulsion Of Cells Pathway antibodies  EPH-ephrin Mediated Repulsion Of Cells Pathway Diagram

Diseases associated with CLTC blocking peptide

 Disease Name  Pubmed Publications
 Lymphoma, Large B-Cell, Diffuse Antibodies  >12 publications with CLTC and Lymphoma, Large B-Cell, Diffuse
 Carcinoma Antibodies  >11 publications with CLTC and Carcinoma
 Adenocarcinoma Antibodies  >7 publications with CLTC and Adenocarcinoma
 Kidney Diseases Antibodies  >7 publications with CLTC and Kidney Diseases
 Inflammation Antibodies  >5 publications with CLTC and Inflammation
 Lung Neoplasms Antibodies  >3 publications with CLTC and Lung Neoplasms
 Neoplasms, Experimental Antibodies  >2 publications with CLTC and Neoplasms, Experimental
 Breast Neoplasms Antibodies  >2 publications with CLTC and Breast Neoplasms
 Liver Diseases Antibodies  >1 publications with CLTC and Liver Diseases
 Liver Neoplasms Antibodies  >1 publications with CLTC and Liver Neoplasms

Organs/Tissues associated with CLTC blocking peptide

 Organ/Tissue Name  Pubmed Publications
 Muscle Antibodies  >14 publications with CLTC and Muscle
 Kidney Antibodies  >7 publications with CLTC and Kidney
 Blood Antibodies  >6 publications with CLTC and Blood
 Lymph Antibodies  >5 publications with CLTC and Lymph
 Lymph Node Antibodies  >5 publications with CLTC and Lymph Node
 Lung Antibodies  >4 publications with CLTC and Lung
 Bone Marrow Antibodies  >3 publications with CLTC and Bone Marrow
 Bone Antibodies  >3 publications with CLTC and Bone
 Liver Antibodies  >2 publications with CLTC and Liver
 Stomach Antibodies  >2 publications with CLTC and Stomach
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