Csgalnact1 Blocking Peptide

This gene encodes an enzyme that transfers N-acetylglucosamine (GalNAc) to the core tetrasaccharide linker and to elongating chondroitin sulfate chains in proteoglycans. Knockout of the orthologous mouse gene indicates that the protein is necessary for normal cartilage development and aggrecan metabolism. Mutations in this gene are associated with multiple sclerosis progression, and with mild skeletal dysplasia and joint laxity. [provided by RefSeq, Aug 2017]

ChGn: Transfers 1,4-N-acetylgalactosamine (GalNAc) from UDP- GalNAc to the non-reducing end of glucuronic acid (GlcUA). Required for addition of the first GalNAc to the core tetrasaccharide linker and for elongation of chondroitin chains. Important role in chondroitin chain biosynthesis in cartilage. Belongs to the chondroitin N- acetylgalactosaminyltransferase family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Transferase; Membrane protein, integral; Glycan Metabolism - chondroitin sulfate biosynthesis; EC 2.4.1.174

Chromosomal Location of Human Ortholog: 8p21.3

Cellular Component: Golgi membrane; integral to Golgi membrane; intracellular

Molecular Function: glucuronosyltransferase activity; metal ion binding; acetylgalactosaminyltransferase activity; glucuronylgalactosylproteoglycan 4-beta-N-acetylgalactosaminyltransferase activity; peptidoglycan glycosyltransferase activity; glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity

Biological Process: nervous system development; anatomical structure morphogenesis; extracellular matrix organization and biogenesis; chondroitin sulfate biosynthetic process; glycosaminoglycan metabolic process; chondroitin sulfate proteoglycan biosynthetic process; cell recognition; pathogenesis; UDP-N-acetylgalactosamine metabolic process; chondroitin sulfate metabolic process; cell proliferation; UDP-glucuronate metabolic process; heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process; heparin biosynthetic process; cartilage development; proteoglycan biosynthetic process; carbohydrate metabolic process; chondroitin sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process; dermatan sulfate proteoglycan biosynthetic process; endochondral ossification