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Mouse Ctr9 Blocking Peptide (C-Term) Blocking Peptide

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS9229470

Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II and is implicated in regulation of development and maintenance of embryonic stem cell pluripotency. PAF1C associates with RNA polymerase II through… More details

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Product Overview

Online Datasheet in PDF
Product Name
Ctr9, Blocking Peptide
Full Product Name
Mouse Ctr9 Blocking Peptide (C-term)
Product Gene Name
Ctr9 blocking peptide
Product Synonym Gene Name
Kiaa0155; Sh2bp1
Product Synonym Names
RNA polymerase-associated protein CTR9 homolog; SH2 domain-binding protein 1; Tetratricopeptide repeat-containing; SH2-binding phosphoprotein of 150 kDa; TPR-containing; SH2-binding phosphoprotein of 150 kDa; p150TSP; Ctr9; Kiaa0155; Sh2bp1
Form/Format
Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
Specificity
The synthetic peptide sequence is selected from aa 1022-1036 of HUMAN Ctr9
Preparation and Storage
Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.
Antibody/Peptide Pairs
Ctr9 peptide (MBS9229470) is used for blocking the activity of Ctr9 antibody (MBS9201323)
Molecular Weight
123,864 Da
Cellular Location
Nucleus speckle
Tissue Location
Widely expressed.

Other Notes

Small volumes of Ctr9 blocking peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Ctr9 purchase

MBS9229470 is a blocking peptide targeting Ctr9. Also known as Mouse Ctr9 Blocking Peptide (C-term).

Additional Details

NCBI/Uniprot data below describe general gene information for Ctr9. It may not necessarily be applicable to this product.

NCBI GI #
91208163
NCBI GeneID
22083
NCBI Accession #
Q62018.2
UniProt Primary Accession #
Q62018
UniProt Secondary Accession #
Q3UFF5; Q3UY40; Q66JX4; Q7TPS6; Q8BND9; Q8BRD1; Q8C9W7; Q8C9Y3; Q8CHI1
UniProt Related Accession #
Q62018
NCBI Official Full Name
RNA polymerase-associated protein CTR9 homolog
NCBI Official Synonym Full Names
CTR9 homolog, Paf1/RNA polymerase II complex component
NCBI Official Symbol
Ctr9
NCBI Official Synonym Symbols
Tsp; Tsbp; Sh2bp1; AA409336; mKIAA0155
UniProt Protein Name
RNA polymerase-associated protein CTR9 homolog
UniProt Synonym Protein Names
SH2 domain-binding protein 1; Tetratricopeptide repeat-containing, SH2-binding phosphoprotein of 150 kDa; TPR-containing, SH2-binding phosphoprotein of 150 kDa; p150TSP
Protein Family
RNA polymerase-associated protein
UniProt Gene Name
Ctr9
UniProt Synonym Gene Names
Kiaa0155; Sh2bp1; TPR-containing, SH2-binding phosphoprotein of 150 kDa; p150TSP
UniProt Entry Name
CTR9_MOUSE
NCBI Protein Information
RNA polymerase-associated protein CTR9 homolog

UniProt Comments for Ctr9

SH2BP1: Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II and is implicated in regulation of development and maintenance of embryonic stem cell pluripotency. PAF1C associates with RNA polymerase II through interaction with POLR2A CTD non- phosphorylated and 'Ser-2'- and 'Ser-5'-phosphorylated forms and is involved in transcriptional elongation, acting both indepentently and synergistically with TCEA1 and in cooperation with the DSIF complex and HTATSF1. PAF1C is required for transcription of Hox and Wnt target genes. PAF1C is involved in hematopoiesis and stimulates transcriptional activity of MLL1; it promotes leukemogenesis though association with MLL-rearranged oncoproteins, such as MLL-MLLT3/AF9 and MLL-MLLT1/ENL. PAF1C is involved in histone modifications such as ubiquitination of histone H2B and methylation on histone H3 'Lys-4' (H3K4me3). PAF1C recruits the RNF20/40 E3 ubiquitin-protein ligase complex and the E2 enzyme UBE2A or UBE2B to chromatin which mediate monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1); UB2A/B-mediated H2B ubiquitination is proposed to be coupled to transcription. PAF1C is involved in mRNA 3' end formation probably through association with cleavage and poly(A) factors. In case of infection by influenza A strain H3N2, PAF1C associates with viral NS1 protein, thereby regulating gene transcription. Required for mono- and trimethylation on histone H3 'Lys-4' (H3K4me3) and dimethylation on histone H3 'Lys-79' (H3K4me3). Required for Hox gene transcription. Required for the trimethylation of histone H3 'Lys-4' (H3K4me3) on genes involved in stem cell pluripotency; this function is synergistic with CXXC1 indicative for an involvement of the SET1 complex. Involved in transcriptional regulation of IL6-responsive genes and in JAK-STAT pathway; may regulate DNA-association of STAT3.

Protein type: Transcription regulation

Cellular Component: nucleus

Molecular Function: protein binding; SH2 domain binding

Biological Process: blastocyst growth; endodermal cell fate commitment; histone H2B ubiquitination; histone monoubiquitination; inner cell mass cell differentiation; JAK-STAT cascade; negative regulation of myeloid cell differentiation; negative regulation of transcription from RNA polymerase II promoter; positive regulation of histone H3-K4 methylation; positive regulation of RNA elongation from RNA polymerase II promoter; positive regulation of transcription from RNA polymerase II promoter; stem cell maintenance; trophectodermal cell differentiation
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Research Articles on Ctr9

1. these data propose a novel feed-forward loop of IL-17 transcriptional regulatory circuit, via IL-6-mediated repression of CTR9 which is a transcriptional repressor of IL-17.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with Ctr9 blocking peptide

 Products by Pathway  Pathway Diagram
 PluriNetWork Pathway antibodies  PluriNetWork Pathway Diagram

Diseases associated with Ctr9 blocking peptide

 Disease Name  Pubmed Publications
 Breast Neoplasms Antibodies  >2 publications with Ctr9 and Breast Neoplasms
 Inflammation Antibodies  >2 publications with Ctr9 and Inflammation
 Disease Models, Animal Antibodies  >1 publications with Ctr9 and Disease Models, Animal
 Cell Transformation, Neoplastic Antibodies  >1 publications with Ctr9 and Cell Transformation, Neoplastic
 Kidney Diseases Antibodies  >1 publications with Ctr9 and Kidney Diseases

Organs/Tissues associated with Ctr9 blocking peptide

 Organ/Tissue Name  Pubmed Publications
 Heart Antibodies  >2 publications with Ctr9 and Heart
 Kidney Antibodies  >2 publications with Ctr9 and Kidney
 Muscle Antibodies  >2 publications with Ctr9 and Muscle
 Joint Antibodies  >1 publications with Ctr9 and Joint
 Spleen Antibodies  >1 publications with Ctr9 and Spleen
 Bone Antibodies  >1 publications with Ctr9 and Bone
 Liver Antibodies  >1 publications with Ctr9 and Liver
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