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CYP51A1 Antibody (Center) Blocking Peptide

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS9227899

Catalyzes C14-demethylation of lanosterol; it transforms lanosterol into 4,4'-dimethyl cholesta-8,14,24-triene-3-beta-ol. More details

$455 / 0.5 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
CYP51A1, Blocking Peptide
Full Product Name
CYP51A1 Antibody (Center) Blocking Peptide
Product Gene Name
Product Synonym Gene Name
CYP51
Product Synonym Names
Lanosterol 14-alpha demethylase; LDM; CYPLI; Cytochrome P450 51A1; Cytochrome P450-14DM; Cytochrome P45014DM; Cytochrome P450LI; Sterol 14-alpha demethylase; CYP51A1; CYP51
Form/Format
Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
Specificity
The synthetic peptide sequence used to generate the antibody was selected from the Center region of human CYP51A1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Preparation and Storage
Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.
Antibody/Peptide Pairs
CYP51A1 peptide (MBS9227899) is used for blocking the activity of CYP51A1 antibody (MBS9212251)
Molecular Weight
46,312 Da
OMIM
601637
Cellular Location
Endoplasmic reticulum membrane. Microsome membrane
Tissue Location
Ubiquitously expressed with highest levels in testis, ovary, adrenal, prostate, liver, kidney and lung

Other Notes

Small volumes of CYP51A1 blocking peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CYP51A1 purchase

MBS9227899 is a blocking peptide targeting CYP51A1. Also known as CYP51A1 Antibody (Center) Blocking Peptide.

Additional Details

NCBI/Uniprot data below describe general gene information for CYP51A1. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
Lanosterol 14-alpha demethylase
NCBI Official Synonym Full Names
cytochrome P450 family 51 subfamily A member 1
NCBI Official Symbol
CYP51A1
NCBI Official Synonym Symbols
LDM; CP51; CYP51; CYPL1; P450L1; P450-14DM
UniProt Protein Name
Lanosterol 14-alpha demethylase
UniProt Synonym Protein Names
CYPLI; Cytochrome P450 51A1; Cytochrome P450-14DM; Cytochrome P45014DM; Cytochrome P450LI; Sterol 14-alpha demethylase
UniProt Gene Name
CYP51A1
UniProt Synonym Gene Names
CYP51; LDM; Cytochrome P45014DM
UniProt Entry Name
CP51A_HUMAN
NCBI Protein Information
lanosterol 14-alpha demethylase

NCBI Summary for CYP51A1

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This endoplasmic reticulum protein participates in the synthesis of cholesterol by catalyzing the removal of the 14alpha-methyl group from lanosterol. Homologous genes are found in all three eukaryotic phyla, fungi, plants, and animals, suggesting that this is one of the oldest cytochrome P450 genes. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]
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UniProt Comments for CYP51A1

CYP51A1: Catalyzes C14-demethylation of lanosterol; it transforms lanosterol into 4,4'-dimethyl cholesta-8,14,24-triene-3-beta-ol. Belongs to the cytochrome P450 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Oxidoreductase; Lipid Metabolism - steroid biosynthesis; EC 1.14.13.70

Chromosomal Location of Human Ortholog: 7q21.2

Cellular Component: endoplasmic reticulum; endoplasmic reticulum membrane; membrane; plasma membrane

Molecular Function: heme binding; sterol 14-demethylase activity

Biological Process: cholesterol biosynthetic process; cholesterol biosynthetic process via 24,25-dihydrolanosterol; steroid biosynthetic process; sterol metabolic process
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

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