DARC Blocking Peptide

Name: DARC Blocking Peptide; MyBioSource
Brand: MyBioSource
SKU: MBS152356
Price: 210 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS152356

MBS152356 is a blocking peptide targeting DARC. Also known as DARC Peptide. More details

$210 / 0.05 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

DARC, Blocking Peptide

Full Product Name

DARC Peptide

Product Gene Name

DARC blocking peptide

Product Synonym Names

FY; Dfy; GPD; GpFy; ACKR1; CCBP1; CD234; WBCQ1; FY; Atypical chemokine receptor 1; Duffy blood group, chemokine receptor

Form/Format

Liquid

Concentration

200 ug/mL (lot specific)

Preparation and Storage

Store DARC peptide at -20 degree C, stable for one year.

Antibody/Peptide Pairs

DARC peptide (MBS152356) is used for blocking the activity of DARC antibody (MBS151236)

Molecular Weight

35,678 Da

OMIM

phenotype 613665

Species

Human

Buffer

PBS pH 7.2 (10 mM NaH2PO4, 10 mM Na2HPO4, 130 mM NaCl) containing 0.1% bovine serum albumin and 0.02% sodium azide

Location

18 amino acids near the amino terminus of human DARC

Applications Tested/Suitable for DARC blocking peptide

Blocking (BL)

Application Notes for DARC blocking peptide

DARC peptide is used for blocking the activity of DARC antibody.

Other Notes

Small volumes of DARC blocking peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for DARC. It may not necessarily be applicable to this product.

NCBI GI #

67476970

NCBI GeneID

2532

NCBI Accession #

Q16570.3

UniProt Primary Accession #

Q16570

UniProt Secondary Accession #

O75898; Q16300; Q8WWE3; Q9UJP0; Q9UKZ5; Q9UKZ6; Q9UQE1; A8YPG5

UniProt Related Accession #

Q16570

NCBI Official Full Name

Atypical chemokine receptor 1

NCBI Official Synonym Full Names

atypical chemokine receptor 1 (Duffy blood group)

NCBI Official Symbol

ACKR1

NCBI Official Synonym Symbols

FY; Dfy; GPD; DARC; GpFy; CCBP1; CD234; WBCQ1

UniProt Protein Name

Atypical chemokine receptor 1

UniProt Synonym Protein Names

Duffy antigen/chemokine receptor; Fy glycoprotein; GpFy; Glycoprotein D; Plasmodium vivax receptor; CD_antigen: CD234

Protein Family

Darcynin

UniProt Gene Name

ACKR1

UniProt Synonym Gene Names

DARC; FY; GPD; GpFy

UniProt Entry Name

ACKR1_HUMAN

NCBI Protein Information

atypical chemokine receptor 1; glycoprotein D; Fy glycoprotein; Duffy blood group antigen; plasmodium vivax receptor; Duffy blood group, chemokine receptor; Duffy blood group, atypical chemokine receptor

NCBI Summary for DARC

The protein encoded by this gene is a glycosylated membrane protein and a non-specific receptor for several chemokines. The encoded protein is the receptor for the human malarial parasites Plasmodium vivax and Plasmodium knowlesi. Polymorphisms in this gene are the basis of the Duffy blood group system. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

UniProt Comments for DARC

DARC: Non-specific receptor for many chemokines such as IL-8, GRO, RANTES, MCP-1 and TARC. It is also the receptor for the human malaria parasites Plasmodium vivax and Plasmodium knowlesi. Belongs to the G-protein coupled receptor Duffy family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Receptor, GPCR; Membrane protein, integral; Membrane protein, multi-pass; GPCR, Duffy family

Chromosomal Location of Human Ortholog: 1q21-q22

Cellular Component: recycling endosome; early endosome; integral to membrane; plasma membrane

Molecular Function: G-protein coupled receptor activity; transmembrane receptor activity; C-C chemokine binding; receptor activity

Biological Process: G-protein coupled receptor protein signaling pathway; defense response; inflammatory response; regulation of chemokine production

Disease: White Blood Cell Count Quantitative Trait Locus 1; Blood Group, Duffy System; Malaria, Susceptibility To

Research Articles on DARC

1. DARC polymorphisms may influence the naturally acquired inhibitory anti-Duffy binding protein II immunity

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with DARC blocking peptide

Products by Pathway	Pathway Diagram
Class A/1 (Rhodopsin-like Receptors) Pathway antibodies	Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway antibodies	Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway Diagram
Disease Pathway antibodies	Disease Pathway Diagram
GPCR Ligand Binding Pathway antibodies	GPCR Ligand Binding Pathway Diagram
GPCRs, Other Pathway antibodies	GPCRs, Other Pathway Diagram
Malaria Pathway antibodies	Malaria Pathway Diagram
Malaria Pathway antibodies	Malaria Pathway Diagram
Metabolic Disorders Of Biological Oxidation Enzymes Pathway antibodies	Metabolic Disorders Of Biological Oxidation Enzymes Pathway Diagram
Peptide GPCRs Pathway antibodies	Peptide GPCRs Pathway Diagram
Peptide Ligand-binding Receptors Pathway antibodies	Peptide Ligand-binding Receptors Pathway Diagram

Diseases associated with DARC blocking peptide

Disease Name	Pubmed Publications
Brain Diseases Antibodies	>1 publications with DARC and Brain Diseases
Inflammation Antibodies	>1 publications with DARC and Inflammation

Organs/Tissues associated with DARC blocking peptide

Organ/Tissue Name	Pubmed Publications
Brain Antibodies	>1 publications with DARC and Brain