DDX20 Antibody (C-Term) Blocking Peptide

DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, which has an ATPase activity and is a component of the survival of motor neurons (SMN) complex. This protein interacts directly with SMN, the spinal muscular atrophy gene product, and may play a catalytic role in the function of the SMN complex on RNPs. [provided by RefSeq, Jul 2008]

GEMIN3: an ubiquitous DEAD box protein, which has an ATPase activity and is a component of the survival of motor neurons (SMN) complex. Interacts directly with SMN, the spinal muscular atrophy gene product, and may play a catalytic role in the function of the SMN complex on RNPs. DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp, are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly.

Protein type: Helicase; EC 3.6.4.13; RNA splicing; Nuclear receptor co-regulator

Chromosomal Location of Human Ortholog: 1p21.1-p13.2

Cellular Component: cytoplasm; cytoskeleton; cytosol; membrane; nucleoplasm; nucleus; SMN complex

Molecular Function: ATP-dependent RNA helicase activity; protein binding

Biological Process: assembly of spliceosomal tri-snRNP; negative regulation of transcription from RNA polymerase II promoter; nuclear import; positive regulation of apoptosis; RNA processing; RNA secondary structure unwinding; spliceosomal snRNP biogenesis