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DEF6 Antibody (C-Term) Blocking Peptide

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS9221812

Phosphatidylinositol 3,4,5-trisphosphate-dependent guanine nucleotide exchange factor (GEF) which plays a role in the activation of Rho GTPases RAC1, RhoA and CDC42. Can regulate cell morphology in cooperation with activated RAC1. Plays a role in Th2 (T… More details

$455 / 0.5 mg +1 FREE 8GB USB
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
DEF6, Blocking Peptide
Full Product Name
DEF6 Antibody (C-term) Blocking Peptide
Product Gene Name
Product Synonym Gene Name
IBP
Product Synonym Names
Differentially expressed in FDCP 6 homolog; DEF-6; IRF4-binding protein; DEF6; IBP
Form/Format
Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
Preparation and Storage
Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.
Antibody/Peptide Pairs
DEF6 peptide (MBS9221812) is used for blocking the activity of DEF6 antibody (MBS9210665)
Molecular Weight
73,910 Da
OMIM
610094
Cellular Location
Cytoplasm. Cell membrane. Nucleus. Note: Recruited to the plasma membrane upon binding phosphatidylinositol 3,4,5-trisphosphate
Tissue Location
Broadly expressed in the immune system and can be detected in T and B-cells.

Other Notes

Small volumes of DEF6 blocking peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for DEF6 purchase

MBS9221812 is a blocking peptide targeting DEF6. Also known as DEF6 Antibody (C-term) Blocking Peptide.

Additional Details

NCBI/Uniprot data below describe general gene information for DEF6. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
Differentially expressed in FDCP 6 homolog
NCBI Official Synonym Full Names
DEF6, guanine nucleotide exchange factor
NCBI Official Symbol
DEF6
NCBI Official Synonym Symbols
IBP; SLAT; SWAP70L
UniProt Protein Name
Differentially expressed in FDCP 6 homolog
UniProt Synonym Protein Names
IRF4-binding protein
UniProt Gene Name
DEF6
UniProt Synonym Gene Names
IBP; DEF-6
UniProt Entry Name
DEFI6_HUMAN
NCBI Protein Information
differentially expressed in FDCP 6 homolog

NCBI Summary for DEF6

DEF6, or IBP, is a guanine nucleotide exchange factor (GEF) for RAC (MIM 602048) and CDC42 (MIM 116952) that is highly expressed in B and T cells (Gupta et al., 2003 [PubMed 12923183]).[supplied by OMIM, Mar 2008]

UniProt Comments for DEF6

DEF6: Phosphatidylinositol 3,4,5-trisphosphate-dependent guanine nucleotide exchange factor (GEF) which plays a role in the activation of Rho GTPases RAC1, RhoA and CDC42. Can regulate cell morphology in cooperation with activated RAC1. Plays a role in Th2 (T helper cells) development and/or activation, perhaps by interfering with ZAP70 signaling.

Protein type: GEFs, Rac/Rho; GEFs

Chromosomal Location of Human Ortholog: 6p21.33-p21.1

Cellular Component: membrane

Molecular Function: protein binding
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

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