Dexras1 Blocking Peptide

This gene encodes a member of the Ras superfamily of small GTPases and is induced by dexamethasone. The encoded protein is an activator of G-protein signaling and acts as a direct nucleotide exchange factor for Gi-Go proteins. This gene may play a role in dexamethasone-induced alterations in cell morphology, growth and cell-extracellular matrix interactions. [provided by RefSeq, Nov 2015]

RASD1: Small GTPase. Negatively regulates the transcription regulation activity of the APBB1/FE65-APP complex via its interaction with APBB1/FE65. Forms a ternary complex with CAPON and NOS1. Component of a complex, at least composed of APBB1, RASD1/DEXRAS1 and APP. Interacts with APBB1/FE65. By dexamethasone. Expressed in a variety of tissues including heart, cardiovascular tissues, brain, placenta, lung, liver, skeletal muscle, kidney, pancreas, gastrointestinal and reproductive tissues. Belongs to the small GTPase superfamily. RasD family.

Protein type: G protein, monomeric, RasD; G protein, monomeric; G protein

Cellular Component: cytoplasm; membrane; nucleus; perinuclear region of cytoplasm; plasma membrane; sarcoplasmic reticulum

Molecular Function: GTP binding; nucleotide binding; protein binding

Biological Process: negative regulation of transcription, DNA-dependent; nitric oxide mediated signal transduction; signal transduction; small GTPase mediated signal transduction