DIS3L Blocking Peptide

Function: Putative cytoplasm-specific catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. Ref.6 Ref.7

Cofactor: Magnesium. Ref.6 Ref.7

Subunit structure: Component of the RNA exosome complex. The catalytically inactive RNA exosome core (Exo-9) complex is believed to associate with catalytic subunits EXOSC10, and DIS3 or DIS3L in cytoplasmic- and nuclear-specific RNA exosome complex forms.

Subcellular location: Cytoplasm Ref.6 Ref.7.

Sequence similarities: Belongs to the RNR ribonuclease family.

Sequence caution: The sequence BAB85541.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.