E2F1 Blocking Peptide

Name: E2F1 Blocking Peptide; MyBioSource
Brand: MyBioSource
SKU: MBS3249931
Price: 195 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS3249931

The protein encoded by E2F1 is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor… More details

$195 / 0.1 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

E2F1, Blocking Peptide

Full Product Name

E2F1 Peptide

Product Gene Name

E2F1 blocking peptide

Product Synonym Names

E2F-1; RBAP1; RBBP3; RBP3

Form/Format

Lyophilized powder

Preparation and Storage

Add 100ul of sterile PBS. Final peptide concentration is 1 mg/ml in PBS. For longer periods of storage, store at -20 degree C. Avoid repeat freeze-thaw cycles.

Antibody/Peptide Pairs

E2F1 peptide (MBS3249931) is used for blocking the activity of E2F1 antibody (MBS3200350)

Molecular Weight

46,920 Da

OMIM

189971

Partner Proteins

E2F2, E2F4, RBL2, BARD1, BIRC5, BRCA1, CBX5, CCDC76, CCNA1, CCNA2, CDC25A, CDC6, CDK1, CDKN2A, CEBPD, CEBPE, CHEK1, CSDA, E2F1, EAPP, FHL2, GAB2, GAS2L1, HIST1H2AG, HIST1H2BJ, HIST2H4A, JMY, MAD2L1, MAD2L1, MDM4, MFAP1, MLH1, MSH2, MSH2, MT1G, MYBL2, MYC, NCOA3, PPP1R13B, PPP1R13B, PRR11, RAD51, RAD54L, RB1, RB1, RB1, RB1, RB1, RB1, RBL1, RBL2, RECQL, TFDP1, TP53BP2, TP53BP2, TP53INP1, TTK, TYMS, UXT, ARID3A, ATM, ATR, BRCA1, BRD2, CCNA1, CCNA2, CDK1, CDK3, CDK7, CDKN2A, CEBPE, CHEK2, CREBBP, CTDP1, CUL1, DDB2, E2F6, GTF2H1, KAT5, MDM4, MNAT1, NCOA3, NCOA6, NDN, NFKB1, NPDC1, PARP1, PHB, PURA, RB1, SERTAD2, SKP2, SP1, SP2, SP3, SP4, TFDP1, TFDP2, TOPBP1, TP53, TP53BP1, TRRAP, ARID3A, BRD2, CCNA1, CCNA2, CDK2, CDK7, CDT1, CREBBP, CUL1, DNMT1, FHL2, GSK3B, GTF2H1, HDAC1, MDM4, MGA, MYBL2, NCOA6, NDN, NDNL2, NFKB1, NPDC1, Nfkb1, PHB, PKIB, PURA, RB1, RBBP4, RBL1, RING1, RNF144A, SKP2, SP1, SP2, SP3, SP4, SPIB, Sp1, TEAD3, TFDP1, TFDP2, TOPBP1, TP53BP1, TRRAP, UBC

Protein Size

437

Applications Tested/Suitable for E2F1 blocking peptide

Western Blot (WB)

Application Notes for E2F1 blocking peptide

This is a synthetic peptide designed for use in combination with anti-E2F1 antibody . It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.

Product References and Citations for E2F1 blocking peptide

Unoki,M., et al., (2004) Oncogene 23 (46), 7601-7610

Other Notes

Small volumes of E2F1 blocking peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for E2F1 purchase

MBS3249931 is a blocking peptide targeting E2F1. Also known as E2F1 Peptide.

Additional Details

NCBI/Uniprot data below describe general gene information for E2F1. It may not necessarily be applicable to this product.

NCBI GI #

12669911

NCBI GeneID

1869

NCBI Accession #

NP_005216

NCBI Related Accession #

NM_005225

UniProt Primary Accession #

Q01094

UniProt Secondary Accession #

Q13143; Q92768

UniProt Related Accession #

Q01094

GenBank Nucleotide #

NM_005225

NCBI Official Full Name

transcription factor E2F1

NCBI Official Synonym Full Names

E2F transcription factor 1

NCBI Official Symbol

E2F1

NCBI Official Synonym Symbols

RBP3; E2F-1; RBAP1; RBBP3

UniProt Protein Name

Transcription factor E2F1

UniProt Synonym Protein Names

PBR3; Retinoblastoma-associated protein 1; RBAP-1; Retinoblastoma-binding protein 3; RBBP-3; pRB-binding protein E2F-1

Protein Family

Transcription factor

UniProt Gene Name

E2F1

UniProt Synonym Gene Names

RBBP3; E2F-1; RBAP-1; RBBP-3

UniProt Entry Name

E2F1_HUMAN

NCBI Protein Information

transcription factor E2F1; PBR3; PRB-binding protein E2F-1; RBAP-1; RBBP-3; retinoblastoma-associated protein 1; retinoblastoma-binding protein 3

UniProt Comments for E2F1

E2F1: a member of the E2F/DP family of transcription factors.The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. Binds DNA cooperatively with Dp transcription factors in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication.The Dp-1/E2F complex functions in the control of cell-cycle progression from G1 to S phase. The E2F-1 complex binds specifically hypophosphorylated retinoblastoma protein RB1. During the cell cycle, RB1 becomes phosphorylated in mid-to-late G1 phase, detaches from the DRTF1/E2F complex, rendering E2F transcriptionally active. Phosphorylated by CDK2 and cyclin A-CDK2 in the S-phase. It can mediate both cell proliferation and p53-dependent apoptosis.

Protein type: DNA-binding; Transcription factor

Chromosomal Location of Human Ortholog: 20q11.2

Cellular Component: nucleoplasm; Rb-E2F complex; cytoplasm; nucleus

Molecular Function: protein binding; DNA binding; sequence-specific DNA binding; transcription factor binding; transcription factor activity

Biological Process: Notch signaling pathway; transcription, DNA-dependent; apoptosis; positive regulation of transcription, DNA-dependent; mRNA stabilization; negative regulation of transcription from RNA polymerase II promoter; anoikis; positive regulation of fibroblast proliferation; DNA damage response, signal transduction resulting in induction of apoptosis; regulation of transcription, DNA-dependent; DNA damage checkpoint; forebrain development; spermatogenesis; positive regulation of transcription from RNA polymerase II promoter; mitotic cell cycle; negative regulation of transcription, DNA-dependent; G1/S transition of mitotic cell cycle

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with E2F1 blocking peptide

Reference Product	PubMed Publications
MYC blocking peptide	>222 publications with E2F1 and MYC
E2F4 blocking peptide	>190 publications with E2F1 and E2F4
E2F2 blocking peptide	>159 publications with E2F1 and E2F2
CDKN2A blocking peptide	>136 publications with E2F1 and CDKN2A
TFDP1 blocking peptide	>89 publications with E2F1 and TFDP1
SP1 blocking peptide	>82 publications with E2F1 and SP1
ATM blocking peptide	>52 publications with E2F1 and ATM
RBL1 blocking peptide	>38 publications with E2F1 and RBL1
RBL2 blocking peptide	>37 publications with E2F1 and RBL2
CDC25A blocking peptide	>36 publications with E2F1 and CDC25A

Pathways associated with E2F1 blocking peptide

Products by Pathway	Pathway Diagram
Activation Of BH3-only Proteins Pathway antibodies	Activation Of BH3-only Proteins Pathway Diagram
Activation Of NOXA And Translocation To Mitochondria Pathway antibodies	Activation Of NOXA And Translocation To Mitochondria Pathway Diagram
Activation Of PUMA And Translocation To Mitochondria Pathway antibodies	Activation Of PUMA And Translocation To Mitochondria Pathway Diagram
Adipogenesis Pathway antibodies	Adipogenesis Pathway Diagram
Apoptosis Pathway antibodies	Apoptosis Pathway Diagram
Assembly Of The Pre-replicative Complex Pathway antibodies	Assembly Of The Pre-replicative Complex Pathway Diagram
Association Of Licensing Factors With The Pre-replicative Complex Pathway antibodies	Association Of Licensing Factors With The Pre-replicative Complex Pathway Diagram
Bladder Cancer Pathway antibodies	Bladder Cancer Pathway Diagram
Bladder Cancer Pathway antibodies	Bladder Cancer Pathway Diagram
CDC6 Association With The ORC:origin Complex Pathway antibodies	CDC6 Association With The ORC:origin Complex Pathway Diagram

Diseases associated with E2F1 blocking peptide

Disease Name	Pubmed Publications
Neoplasms Antibodies	>971 publications with E2F1 and Neoplasms
Breast Neoplasms Antibodies	>137 publications with E2F1 and Breast Neoplasms
Cell Transformation, Neoplastic Antibodies	>129 publications with E2F1 and Cell Transformation, Neoplastic
Adenocarcinoma Antibodies	>128 publications with E2F1 and Adenocarcinoma
Neoplasms, Experimental Antibodies	>109 publications with E2F1 and Neoplasms, Experimental
Nervous System Diseases Antibodies	>89 publications with E2F1 and Nervous System Diseases
Lung Neoplasms Antibodies	>82 publications with E2F1 and Lung Neoplasms
Liver Neoplasms Antibodies	>75 publications with E2F1 and Liver Neoplasms
Prostatic Neoplasms Antibodies	>72 publications with E2F1 and Prostatic Neoplasms
Liver Diseases Antibodies	>70 publications with E2F1 and Liver Diseases

Organs/Tissues associated with E2F1 blocking peptide

Organ/Tissue Name	Pubmed Publications
Lung Antibodies	>145 publications with E2F1 and Lung
Blood Antibodies	>132 publications with E2F1 and Blood
Brain Antibodies	>130 publications with E2F1 and Brain
Liver Antibodies	>105 publications with E2F1 and Liver
Muscle Antibodies	>96 publications with E2F1 and Muscle
Prostate Antibodies	>89 publications with E2F1 and Prostate
Skin Antibodies	>68 publications with E2F1 and Skin
Bone Antibodies	>55 publications with E2F1 and Bone
Embryonic Tissue Antibodies	>51 publications with E2F1 and Embryonic Tissue
Kidney Antibodies	>43 publications with E2F1 and Kidney