Mouse Ephb1 Blocking Peptide (Center) Blocking Peptide

EphB1: a receptor tyrosine kinase of the Eph family. Receptor for members of the ephrin-B family: ephrin-B1, -B2 and -B3. The Eph receptor tyrosine kinase family, the largest in the tyrosine kinase group, has fourteen members. They bind membrane-anchored ligands, ephrins, at sites of cell-cell contact, regulating the repulsion and adhesion of cells that underlie the establishment, maintenance, and remodeling of patterns of cellular organization. Eph signals are particularly important in regulating cell adhesion and cell migration during development, axon guidance, homeostasis and disease. EphA receptors bind to GPI-anchored ephrin-A ligands, while EphB receptors bind to ephrin-B proteins that have a transmembrane and cytoplasmic domain. Interactions between EphB receptor kinases and ephrin-B proteins transduce signals bidirectionally, signaling to both interacting cell types. Eph receptors and ephrins also regulate the adhesion of endothelial cells and are required for the remodeling of blood vessels. The ligand-activated form of EphB1 interacts with GRB2, GRB10 and NCK through their respective SH2 domains. Four alternatively spliced isoforms are known.

Protein type: EC 2.7.10.1; Membrane protein, integral; Protein kinase, tyrosine (receptor); Protein kinase, TK; Kinase, protein; TK group; Eph family

Cellular Component: axon; cytoplasm; early endosome membrane; filopodium tip; integral to plasma membrane; lipid raft; membrane

Molecular Function: axon guidance receptor activity; protein complex binding; protein-tyrosine kinase activity; transmembrane-ephrin receptor activity

Biological Process: angiogenesis; axon guidance; camera-type eye morphogenesis; cell-substrate adhesion; central nervous system projection neuron axonogenesis; cranial nerve development; ephrin receptor signaling pathway; formation of immunological synapse; optic nerve morphogenesis; protein amino acid autophosphorylation; regulation of JNK cascade; retinal ganglion cell axon guidance