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FABP4 Antibody (Y20) Blocking Peptide

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS9224807

Lipid transport protein in adipocytes. Binds both long chain fatty acids and retinoic acid. Delivers long-chain fatty acids and retinoic acid to their cognate receptors in the nucleus (By similarity). More details

$455 / 0.5 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
FABP4 (Y20), Blocking Peptide
Full Product Name
FABP4 Antibody (Y20) Blocking Peptide
Product Gene Name
FABP4 blocking peptide
Product Synonym Names
Fatty acid-binding protein; adipocyte; Adipocyte lipid-binding protein; ALBP; Adipocyte-type fatty acid-binding protein; A-FABP; AFABP; Fatty acid-binding protein 4; FABP4
Form/Format
Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
Specificity
The synthetic peptide sequence used to generate the antibody was selected from the Y20 region of human FABP4. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Preparation and Storage
Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.
Antibody/Peptide Pairs
FABP4 (Y20) peptide (MBS9224807) is used for blocking the activity of FABP4 antibody (MBS9210294)
Molecular Weight
14,719 Da
OMIM
600434
Cellular Location
Cytoplasm. Nucleus. Note: Depending on the nature of the ligand, a conformation change exposes a nuclear localization motif and the protein is transported into the nucleus. Subject to constitutive nuclear export (By similarity)

Other Notes

Small volumes of FABP4 blocking peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for FABP4 purchase

MBS9224807 is a blocking peptide targeting FABP4. Also known as FABP4 Antibody (Y20) Blocking Peptide.

Additional Details

NCBI/Uniprot data below describe general gene information for FABP4. It may not necessarily be applicable to this product.

NCBI GI #
119781
NCBI GeneID
2167
NCBI Accession #
P15090.3
UniProt Primary Accession #
P15090
UniProt Secondary Accession #
Q6IBA1
UniProt Related Accession #
P15090
NCBI Official Full Name
Fatty acid-binding protein, adipocyte
NCBI Official Synonym Full Names
fatty acid binding protein 4
NCBI Official Symbol
FABP4
NCBI Official Synonym Symbols
aP2; ALBP; AFABP; A-FABP; HEL-S-104
UniProt Protein Name
Fatty acid-binding protein, adipocyte
UniProt Synonym Protein Names
Adipocyte lipid-binding protein; ALBP; Adipocyte-type fatty acid-binding protein; A-FABP; AFABP; Fatty acid-binding protein 4
Protein Family
Fatty acid-binding protein
UniProt Gene Name
FABP4
UniProt Synonym Gene Names
ALBP; A-FABP; AFABP
UniProt Entry Name
FABP4_HUMAN
NCBI Protein Information
fatty acid-binding protein, adipocyte

NCBI Summary for FABP4

FABP4 encodes the fatty acid binding protein found in adipocytes. Fatty acid binding proteins are a family of small, highly conserved, cytoplasmic proteins that bind long-chain fatty acids and other hydrophobic ligands. It is thought that FABPs roles include fatty acid uptake, transport, and metabolism. [provided by RefSeq, Jul 2008]
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UniProt Comments for FABP4

FABP4: a lipid transport protein that is the predominant fatty acid binding protein found in adipocytes. Also expressed in macrophages. Binds both long chain fatty acids and retinoic acid. Delivers long-chain fatty acids and retinoic acid to their cognate receptors in the nucleus. Homodimer. Forms a beta-barrel structure that accommodates hydrophobic ligands in its interior. Interacts with PPARG. Monomer. FABP4 knockout mice fed a high-fat and high-calorie diet become obese but develop neither insulin resistance nor diabetes, suggesting that this protein might be a link between obesity and insulin resistance and diabetes. Mice deficient in both FABP4 and ApoE show protection against atherosclerosis when compared with mice deficient only in ApoE. Mice carrying a FABP4 genetic variant exhibit both reduced FABP4 expression and a reduced potential for developing type 2 diabetes and coronary heart disease. A related study in humans indicated a similar pattern, suggesting that FABP4 may be a potential therapeutic target in the treatment of these disorders. Belongs to the calycin superfamily,fatty-acid binding protein (FABP) family.

Protein type: Lipid-binding

Chromosomal Location of Human Ortholog: 8q21

Cellular Component: cytoplasm; cytosol; lipid particle

Biological Process: triacylglycerol catabolic process
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Research Articles on FABP4

1. Serum irisin might exert antagonistic effects on FABP4 in the middle-aged Chinese population.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with FABP4 blocking peptide

 Reference Product  PubMed Publications
 CEBPA blocking peptide  >115 publications with FABP4 and CEBPA
 LPL blocking peptide  >90 publications with FABP4 and LPL
 CD36 blocking peptide  >57 publications with FABP4 and CD36
 PPARG blocking peptide  >55 publications with FABP4 and PPARG
 ADIPOQ blocking peptide  >49 publications with FABP4 and ADIPOQ
 WNT10B blocking peptide  >14 publications with FABP4 and WNT10B
 PLIN1 blocking peptide  >13 publications with FABP4 and PLIN1
 PPARA blocking peptide  >8 publications with FABP4 and PPARA
 LIPE blocking peptide  >7 publications with FABP4 and LIPE

Pathways associated with FABP4 blocking peptide

 Products by Pathway  Pathway Diagram
 Developmental Biology Pathway antibodies  Developmental Biology Pathway Diagram
 Hormone-sensitive Lipase (HSL)-mediated Triacylglycerol Hydrolysis Pathway antibodies  Hormone-sensitive Lipase (HSL)-mediated Triacylglycerol Hydrolysis Pathway Diagram
 Lipid Digestion, Mobilization, And Transport Pathway antibodies  Lipid Digestion, Mobilization, And Transport Pathway Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Lipids And Lipoproteins Pathway antibodies  Metabolism Of Lipids And Lipoproteins Pathway Diagram
 PPAR Signaling Pathway antibodies  PPAR Signaling Pathway Diagram
 PPAR Signaling Pathway antibodies  PPAR Signaling Pathway Diagram
 Regulation Of Lipolysis In Adipocytes Pathway antibodies  Regulation Of Lipolysis In Adipocytes Pathway Diagram
 Transcriptional Regulation Of White Adipocyte Differentiation Pathway antibodies  Transcriptional Regulation Of White Adipocyte Differentiation Pathway Diagram

Diseases associated with FABP4 blocking peptide

 Disease Name  Pubmed Publications
 Insulin Resistance Antibodies  >179 publications with FABP4 and Insulin Resistance
 Inflammation Antibodies  >126 publications with FABP4 and Inflammation
 Cardiovascular Diseases Antibodies  >107 publications with FABP4 and Cardiovascular Diseases
 Fatty Liver Antibodies  >96 publications with FABP4 and Fatty Liver
 Necrosis Antibodies  >50 publications with FABP4 and Necrosis
 Heart Diseases Antibodies  >41 publications with FABP4 and Heart Diseases
 Liver Diseases Antibodies  >40 publications with FABP4 and Liver Diseases
 Disease Models, Animal Antibodies  >36 publications with FABP4 and Disease Models, Animal
 Weight Gain Antibodies  >29 publications with FABP4 and Weight Gain
 Weight Loss Antibodies  >25 publications with FABP4 and Weight Loss

Organs/Tissues associated with FABP4 blocking peptide

 Organ/Tissue Name  Pubmed Publications
 Adipose Tissue Antibodies  >327 publications with FABP4 and Adipose Tissue
 Blood Antibodies  >261 publications with FABP4 and Blood
 Connective Tissue Antibodies  >217 publications with FABP4 and Connective Tissue
 Muscle Antibodies  >110 publications with FABP4 and Muscle
 Bone Antibodies  >102 publications with FABP4 and Bone
 Vascular Antibodies  >90 publications with FABP4 and Vascular
 Heart Antibodies  >66 publications with FABP4 and Heart
 Brain Antibodies  >33 publications with FABP4 and Brain
 Lung Antibodies  >26 publications with FABP4 and Lung
 Kidney Antibodies  >20 publications with FABP4 and Kidney
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