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FADS2 Blocking Peptide (Center) Blocking Peptide

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS9230867

Component of a lipid metabolic pathway that catalyzes biosynthesis of highly unsaturated fatty acids (HUFA) from precursor essential polyunsaturated fatty acids (PUFA) linoleic acid (LA) (18:2n-6) and alpha-linolenic acid (ALA) (18:3n-3). Catalyzes the first… More details

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Product Overview

Online Datasheet in PDF
Product Name
FADS2, Blocking Peptide
Full Product Name
FADS2 Blocking Peptide (Center)
Product Gene Name
FADS2 blocking peptide
Product Synonym Names
Fatty acid desaturase 2; 11419-; Delta(6) fatty acid desaturase; D6D; Delta(6) desaturase; Delta-6 desaturase; FADS2
Form/Format
Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
Specificity
The synthetic peptide sequence is selected from aa 111-122 of HUMAN FADS2
Preparation and Storage
Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.
Antibody/Peptide Pairs
FADS2 peptide (MBS9230867) is used for blocking the activity of FADS2 antibody (MBS9214936)
Molecular Weight
48,883 Da
OMIM
606149
Cellular Location
Endoplasmic reticulum membrane; Multi-pass membrane protein
Tissue Location
Expressed in a wide array of tissues, highest expression is found in liver followed by brain, lung, heart, and retina. A lower level is found in breast tumor when compared with normal tissues; lowest levels were found in patients with poor prognostic index.

Other Notes

Small volumes of FADS2 blocking peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for FADS2 purchase

MBS9230867 is a blocking peptide targeting FADS2. Also known as FADS2 Blocking Peptide (Center).

Additional Details

NCBI/Uniprot data below describe general gene information for FADS2. It may not necessarily be applicable to this product.

NCBI GI #
158705696
NCBI GeneID
521822
NCBI Accession #
NP_004256.1
UniProt Primary Accession #
O95864
UniProt Secondary Accession #
Q6MZQ7; Q96H07; Q96SV8; Q9H3G3; Q9Y3X4; A8K2M6; B7Z634
UniProt Related Accession #
A4FV48
NCBI Official Full Name
Fatty acid desaturase 2
NCBI Official Symbol
FADS2
UniProt Protein Name
Fatty acid desaturase 2
UniProt Synonym Protein Names
Acyl-CoA 6-desaturase; Delta(6) fatty acid desaturase; D6D; Delta(6) desaturase; Delta-6 desaturase
Protein Family
Fatty acid desaturase
UniProt Gene Name
FADS2
UniProt Synonym Gene Names
D6D; Delta(6) desaturase; Delta-6 desaturase
UniProt Entry Name
FADS2_HUMAN
NCBI Protein Information
fatty acid desaturase 2

UniProt Comments for FADS2

FADS2: Component of a lipid metabolic pathway that catalyzes biosynthesis of highly unsaturated fatty acids (HUFA) from precursor essential polyunsaturated fatty acids (PUFA) linoleic acid (LA) (18:2n-6) and alpha-linolenic acid (ALA) (18:3n-3). Catalyzes the first and rate limiting step in this pathway which is the desaturation of LA (18:2n-6) and ALA (18:3n-3) into gamma- linoleic acid (GLA) (18:3n-6) and stearidonic acid (18:4n-3) respectively and other desaturation steps. Highly unsaturated fatty acids (HUFA) play pivotal roles in many biological functions. It catalizes as well the introduction of a cis double bond in palmitate to produce the mono-unsaturated fatty acid sapienate, the most abundant fatty acid in sebum. Belongs to the fatty acid desaturase family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, multi-pass; Oxidoreductase; Lipid Metabolism - unsaturated fatty acid biosynthesis; Membrane protein, integral; Lipid Metabolism - alpha-linolenic acid; EC 1.14.19.-

Chromosomal Location of Human Ortholog: 11q12.2

Cellular Component: endoplasmic reticulum membrane; integral to plasma membrane; membrane

Molecular Function: linoleoyl-CoA desaturase activity

Biological Process: linoleic acid metabolic process
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with FADS2 blocking peptide

 Products by Pathway  Pathway Diagram
 Biosynthesis Of Unsaturated Fatty Acids Pathway antibodies  Biosynthesis Of Unsaturated Fatty Acids Pathway Diagram
 Biosynthesis Of Unsaturated Fatty Acids Pathway antibodies  Biosynthesis Of Unsaturated Fatty Acids Pathway Diagram
 Fatty Acid Metabolism Pathway antibodies  Fatty Acid Metabolism Pathway Diagram
 Fatty Acid Metabolism Pathway antibodies  Fatty Acid Metabolism Pathway Diagram
 Folic Acid Network Pathway antibodies  Folic Acid Network Pathway Diagram
 Linoleic Acid (LA) Metabolism Pathway antibodies  Linoleic Acid (LA) Metabolism Pathway Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Lipids And Lipoproteins Pathway antibodies  Metabolism Of Lipids And Lipoproteins Pathway Diagram
 PPAR Signaling Pathway antibodies  PPAR Signaling Pathway Diagram
 PPAR Signaling Pathway antibodies  PPAR Signaling Pathway Diagram

Diseases associated with FADS2 blocking peptide

 Disease Name  Pubmed Publications
 Fatty Liver Antibodies  >74 publications with FADS2 and Fatty Liver
 Cardiovascular Diseases Antibodies  >30 publications with FADS2 and Cardiovascular Diseases
 Inflammation Antibodies  >22 publications with FADS2 and Inflammation
 Heart Diseases Antibodies  >18 publications with FADS2 and Heart Diseases
 Liver Diseases Antibodies  >14 publications with FADS2 and Liver Diseases
 Nervous System Diseases Antibodies  >7 publications with FADS2 and Nervous System Diseases
 Carcinoma, Hepatocellular Antibodies  >6 publications with FADS2 and Carcinoma, Hepatocellular
 Depressive Disorder Antibodies  >6 publications with FADS2 and Depressive Disorder
 Hypertension Antibodies  >5 publications with FADS2 and Hypertension
 Weight Gain Antibodies  >5 publications with FADS2 and Weight Gain

Organs/Tissues associated with FADS2 blocking peptide

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >108 publications with FADS2 and Blood
 Liver Antibodies  >81 publications with FADS2 and Liver
 Brain Antibodies  >36 publications with FADS2 and Brain
 Muscle Antibodies  >23 publications with FADS2 and Muscle
 Heart Antibodies  >22 publications with FADS2 and Heart
 Adipose Tissue Antibodies  >22 publications with FADS2 and Adipose Tissue
 Skin Antibodies  >12 publications with FADS2 and Skin
 Vascular Antibodies  >8 publications with FADS2 and Vascular
 Connective Tissue Antibodies  >8 publications with FADS2 and Connective Tissue
 Intestine Antibodies  >8 publications with FADS2 and Intestine
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