FAF1 Blocking Peptide

Interaction of Fas ligand (TNFSF6) with the FAS antigen (TNFRSF6) mediates programmed cell death, also called apoptosis, in a number of organ systems. The protein encoded by this gene binds to FAS antigen and can initiate apoptosis or enhance apoptosis initiated through FAS antigen. Initiation of apoptosis by the protein encoded by this gene requires a ubiquitin-like domain but not the FAS-binding domain. [provided by RefSeq, Jul 2008]

FAF1: a pro-apoptotic protein that binds to FAS antigen. Potentiates but cannot initiate FAS-induced apoptosis. Its pro-apoptotic activity requires a ubiquitin-like domain but not the FAS-binding domain. Phosphorylation by protein kinase CK2 influences transport into nucleus. Two transcript variants encoding different protein isoforms have been described.

Protein type: Nuclear receptor co-regulator; Apoptosis

Chromosomal Location of Human Ortholog: 1p33

Cellular Component: perinuclear region of cytoplasm; CD95 death-inducing signaling complex; nuclear envelope; nucleus; cytosol

Molecular Function: NF-kappaB binding; protein domain specific binding; ubiquitin binding; protein binding; ubiquitin protein ligase binding; heat shock protein binding; protein kinase regulator activity; protein kinase binding

Biological Process: cell death; regulation of cell adhesion; proteasomal ubiquitin-dependent protein catabolic process; cytoplasmic sequestering of NF-kappaB; positive regulation of protein complex assembly; apoptosis; positive regulation of apoptosis; regulation of protein catabolic process; regulation of protein kinase activity