• Call +1.858.633.0165 or Fax +1.858.633.0166 or Contact Us

GIT1 Antibody (Center) Blocking Peptide

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS9226871

GTPase-activating protein for the ADP ribosylation factor family. May serve as a scaffold to bring together molecules to form signaling modules controlling vesicle trafficking, adhesion and cytoskeletal organization. Increases the speed of cell migration, as… More details

$455 / 0.5 mg +1 FREE 8GB USB
Product Documentation
PDF
Sample Manual Insert View PDF
PDF
Testing Data View PDF
PDF
Certificate of Analysis (COA) View PDF
PDF
QC Report View PDF
PDF
Material Safety Data Sheet View PDF
PDF
Technical Datasheet View PDF
PDF
Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
GIT1, Blocking Peptide
Full Product Name
GIT1 Antibody (Center) Blocking Peptide
Product Gene Name
GIT1 blocking peptide
Product Synonym Names
ARF GTPase-activating protein GIT1; ARF GAP GIT1; Cool-associated and tyrosine-phosphorylated protein 1; CAT-1; CAT1; G protein-coupled receptor kinase-interactor 1; GRK-interacting protein 1; GIT1
Form/Format
Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
Specificity
The synthetic peptide sequence used to generate the antibody was selected from the Center region of human GIT1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Preparation and Storage
Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.
Antibody/Peptide Pairs
GIT1 peptide (MBS9226871) is used for blocking the activity of GIT1 antibody (MBS9217142)
Molecular Weight
85,446 Da
OMIM
608434
Cellular Location
Cytoplasm. Note: Cycles between at least 3 distinct intracellular compartments, including focal adhesions, cytoplasmic complexes and membrane protrusions. During cell migration, when cells detach, moves from the adhesions into the cytoplasmic complexes towards the leading edge, while, when cells adhere, it is found in vinculin-containing adhesions. Recruitment to adhesions may be mediated by active tyrosine-phosphorylated paxillin

Other Notes

Small volumes of GIT1 blocking peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for GIT1 purchase

MBS9226871 is a blocking peptide targeting GIT1. Also known as GIT1 Antibody (Center) Blocking Peptide.

Additional Details

NCBI/Uniprot data below describe general gene information for GIT1. It may not necessarily be applicable to this product.

NCBI GI #
45645212
NCBI GeneID
28964
NCBI Accession #
Q9Y2X7.2
UniProt Primary Accession #
Q9Y2X7
UniProt Secondary Accession #
Q86SS0; Q9BRJ4; B4DGU9; B4DSV3
UniProt Related Accession #
Q9Y2X7
NCBI Official Full Name
ARF GTPase-activating protein GIT1
NCBI Official Synonym Full Names
GIT ArfGAP 1
NCBI Official Symbol
GIT1
UniProt Protein Name
ARF GTPase-activating protein GIT1
UniProt Synonym Protein Names
Cool-associated and tyrosine-phosphorylated protein 1; CAT-1; CAT1; G protein-coupled receptor kinase-interactor 1; GRK-interacting protein 1
Protein Family
Adenylate cyclase activation protein
UniProt Gene Name
GIT1
UniProt Synonym Gene Names
ARF GAP GIT1; CAT-1; CAT1
UniProt Entry Name
GIT1_HUMAN
NCBI Protein Information
ARF GTPase-activating protein GIT1

UniProt Comments for GIT1

GIT1: a multidomain, adaptor protein that regulates cellular processes, such as migration and protrusive activity, by bringing together various signaling molecules, including PIX, PAK, and paxillin. Phosphorylation on Ser-709 increases its binding to paxillin and regulates cellular protrusions. Possesses ADP-ribosylation factor (ARF) GTPase-activating protein (GAP) activity. Functions as part of a multi-molecular signaling complex that regulates membrane protrusions and cell migration. Regulates PLC-gamma activation by c-Src and integrates signal transduction by G protein coupled receptors (GPCR)s and tyrosine kinase receptors (TKRs).

Protein type: GAPs, ARF; GAPs; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 17p11.2

Cellular Component: cytoplasm; cytosol; focal adhesion; membrane

Molecular Function: protein binding

Biological Process: ephrin receptor signaling pathway; regulation of cytokinesis; regulation of G-protein coupled receptor protein signaling pathway
Show more

Research Articles on GIT1

1. Results suggested that cyclic phosphorylation-dephosphorylation at Tyr- 554 of Git1 was crucial for dynamic interactions between Git1 and paxillin/Hic-5 in order to ensure coordinated cell motility.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with GIT1 blocking peptide

 Reference Product  PubMed Publications
 CDC42 blocking peptide  >27 publications with GIT1 and CDC42
 PAK1 blocking peptide  >20 publications with GIT1 and PAK1
 ARF6 blocking peptide  >19 publications with GIT1 and ARF6
 PXN blocking peptide  >17 publications with GIT1 and PXN
 ARHGEF7 blocking peptide  >14 publications with GIT1 and ARHGEF7
 PTK2 blocking peptide  >7 publications with GIT1 and PTK2
 ARHGEF6 blocking peptide  >3 publications with GIT1 and ARHGEF6
 EPHA2 blocking peptide  >2 publications with GIT1 and EPHA2
 NCK1 blocking peptide  >2 publications with GIT1 and NCK1
 PLCG1 blocking peptide  >1 publications with GIT1 and PLCG1

Pathways associated with GIT1 blocking peptide

 Products by Pathway  Pathway Diagram
 Arf6 Signaling Events Pathway antibodies  Arf6 Signaling Events Pathway Diagram
 Aurora A Signaling Pathway antibodies  Aurora A Signaling Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 Developmental Biology Pathway antibodies  Developmental Biology Pathway Diagram
 EGFR1 Signaling Pathway antibodies  EGFR1 Signaling Pathway Diagram
 EPH-Ephrin Signaling Pathway antibodies  EPH-Ephrin Signaling Pathway Diagram
 Endocytosis Pathway antibodies  Endocytosis Pathway Diagram
 Endocytosis Pathway antibodies  Endocytosis Pathway Diagram
 Ephrin Signaling Pathway antibodies  Ephrin Signaling Pathway Diagram
 Epithelial Cell Signaling In Helicobacter Pylori Infection Pathway antibodies  Epithelial Cell Signaling In Helicobacter Pylori Infection Pathway Diagram

Diseases associated with GIT1 blocking peptide

 Disease Name  Pubmed Publications
 Carcinoma Antibodies  >10 publications with GIT1 and Carcinoma
 Attention Deficit Disorder with Hyperactivity Antibodies  >7 publications with GIT1 and Attention Deficit Disorder with Hyperactivity
 Neoplasm Invasiveness Antibodies  >5 publications with GIT1 and Neoplasm Invasiveness
 Breast Neoplasms Antibodies  >5 publications with GIT1 and Breast Neoplasms
 Neoplasm Metastasis Antibodies  >4 publications with GIT1 and Neoplasm Metastasis
 Vascular Diseases Antibodies  >4 publications with GIT1 and Vascular Diseases
 Carcinoma, Hepatocellular Antibodies  >3 publications with GIT1 and Carcinoma, Hepatocellular
 Inflammation Antibodies  >3 publications with GIT1 and Inflammation
 Liver Diseases Antibodies  >3 publications with GIT1 and Liver Diseases
 Colonic Neoplasms Antibodies  >3 publications with GIT1 and Colonic Neoplasms

Organs/Tissues associated with GIT1 blocking peptide

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >33 publications with GIT1 and Brain
 Vascular Antibodies  >28 publications with GIT1 and Vascular
 Blood Antibodies  >20 publications with GIT1 and Blood
 Muscle Antibodies  >17 publications with GIT1 and Muscle
 Nerve Antibodies  >13 publications with GIT1 and Nerve
 Lung Antibodies  >11 publications with GIT1 and Lung
 Bone Antibodies  >11 publications with GIT1 and Bone
 Kidney Antibodies  >6 publications with GIT1 and Kidney
 Embryonic Tissue Antibodies  >6 publications with GIT1 and Embryonic Tissue
 Liver Antibodies  >5 publications with GIT1 and Liver
Request a Quote

Please fill out the form below and our representative will get back to you shortly.

MBS000000
Contact Us

Please fill out the form below and our representative will get back to you shortly.

MBS000000