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GPR177 Peptide - Middle Region Blocking Peptide

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS3232331

GPR177 has signal transducer activity. It is positive regulation of I-kappaB kinase/NF-kappaB cascade. More details

$195 / 0.1 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
GPR177, Blocking Peptide
Full Product Name
GPR177 Peptide - middle region
Product Gene Name
GPR177 blocking peptide
Product Synonym Gene Name
C1orf139; EVI; FLJ23091; MGC131760; MGC14878; MRP; WLS; GPR177
Form/Format
Lyophilized powder
Preparation and Storage
Add 100ul of sterile PBS. Final peptide concentration is 1 mg/ml in PBS. For longer periods of storage, store at -20 degree C. Avoid repeat freeze-thaw cycles.
Antibody/Peptide Pairs
GPR177 peptide (MBS3232331) is used for blocking the activity of GPR177 antibody (MBS3207366)
Molecular Weight
62kDa
OMIM
611514

Product Categories/Family for GPR177 blocking peptide

Peptide
Applications Tested/Suitable for GPR177 blocking peptide
Western Blot (WB)

Other Notes

Small volumes of GPR177 blocking peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for GPR177 purchase

MBS3232331 is a blocking peptide targeting GPR177. Also known as GPR177 Peptide - middle region.

Additional Details

NCBI/Uniprot data below describe general gene information for GPR177. It may not necessarily be applicable to this product.

NCBI GI #
301069320
NCBI GeneID
79971
NCBI Accession #
NP_001002292
UniProt Primary Accession #
Q5T9L3
UniProt Related Accession #
Q5T9L3
GenBank Nucleotide #
NM_001002292
NCBI Official Full Name
protein wntless homolog isoform 2
NCBI Official Synonym Full Names
Wnt ligand secretion mediator
NCBI Official Symbol
WLS
NCBI Official Synonym Symbols
EVI; MRP; GPR177; mig-14; C1orf139
UniProt Protein Name
Protein wntless homolog
UniProt Synonym Protein Names
Integral membrane protein GPR177; Protein evenness interrupted homolog; EVI; Putative NF-kappa-B-activating protein 373
Protein Family
Protein wntless
UniProt Gene Name
WLS
UniProt Synonym Gene Names
C1orf139; GPR177; EVI
UniProt Entry Name
WLS_HUMAN
NCBI Protein Information
protein wntless homolog

UniProt Comments for GPR177

GPR177: Regulates Wnt proteins sorting and secretion in a feedback regulatory mechanism. This reciprocal interaction plays a key role in the regulation of expression, subcellular location, binding and organelle-specific association of Wnt proteins. Plays also an important role in establishment of the anterior-posterior body axis formation during development. Belongs to the wntless family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, multi-pass; Membrane protein, integral

Chromosomal Location of Human Ortholog: 1p31.3

Cellular Component: dendrite cytoplasm; Golgi membrane; cytoplasmic vesicle membrane; early endosome membrane; integral to membrane; plasma membrane

Molecular Function: Wnt-protein binding; signal transducer activity; protein binding; mu-type opioid receptor binding

Biological Process: positive regulation of I-kappaB kinase/NF-kappaB cascade; Wnt receptor signaling pathway; mesoderm formation; anterior/posterior axis specification
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Research Articles on GPR177

1. GPR177 as a novel candidate for prognostic marker as well as a promising target for treatment of gastric cancer patients.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with GPR177 blocking peptide

 Products by Pathway  Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 Signal Transduction Pathway antibodies  Signal Transduction Pathway Diagram
 Signaling By WNT In Cancer Pathway antibodies  Signaling By WNT In Cancer Pathway Diagram
 Signaling By Wnt Pathway antibodies  Signaling By Wnt Pathway Diagram
 WNT Ligand Biogenesis And Trafficking Pathway antibodies  WNT Ligand Biogenesis And Trafficking Pathway Diagram
 WNT Ligand Secretion Is Abrogated By The PORCN Inhibitor LGK974 Pathway antibodies  WNT Ligand Secretion Is Abrogated By The PORCN Inhibitor LGK974 Pathway Diagram

Diseases associated with GPR177 blocking peptide

 Disease Name  Pubmed Publications
 Weight Loss Antibodies  >66 publications with GPR177 and Weight Loss
 Nervous System Diseases Antibodies  >14 publications with GPR177 and Nervous System Diseases
 Liver Diseases Antibodies  >7 publications with GPR177 and Liver Diseases
 Kidney Diseases Antibodies  >6 publications with GPR177 and Kidney Diseases
 Breast Neoplasms Antibodies  >5 publications with GPR177 and Breast Neoplasms
 Weight Gain Antibodies  >4 publications with GPR177 and Weight Gain
 Inflammation Antibodies  >4 publications with GPR177 and Inflammation
 Disease Models, Animal Antibodies  >3 publications with GPR177 and Disease Models, Animal
 Adenocarcinoma Antibodies  >3 publications with GPR177 and Adenocarcinoma
 Congenital Abnormalities Antibodies  >3 publications with GPR177 and Congenital Abnormalities

Organs/Tissues associated with GPR177 blocking peptide

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >24 publications with GPR177 and Brain
 Blood Antibodies  >21 publications with GPR177 and Blood
 Bone Antibodies  >16 publications with GPR177 and Bone
 Vascular Antibodies  >13 publications with GPR177 and Vascular
 Liver Antibodies  >12 publications with GPR177 and Liver
 Lung Antibodies  >10 publications with GPR177 and Lung
 Muscle Antibodies  >10 publications with GPR177 and Muscle
 Heart Antibodies  >9 publications with GPR177 and Heart
 Kidney Antibodies  >9 publications with GPR177 and Kidney
 Skin Antibodies  >8 publications with GPR177 and Skin
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