Mouse Hck Blocking Peptide (Center) Blocking Peptide

The protein encoded by this gene is a member of the Src family of tyrosine kinases. This protein is primarily hemopoietic, particularly in cells of the myeloid and B-lymphoid lineages. It may play a role in the innate immune response and the STAT5 signaling pathway. Alternative translation initiation site usage, including a non-AUG (CUG) codon, results in the production of two different isoforms, that have different subcellular localization. [provided by RefSeq, Feb 2010]

Hck: a protein-tyrosine kinase of the Src family that is predominantly expressed in hemopoietic cell types. The encoded protein may help couple the Fc receptor to the activation of the respiratory burst. In addition, it may play a role in neutrophil migration and in the degranulation of neutrophils. Alternate translation initiation site usage, including a non-AUG (CUG) codon, results in the production of two different isoforms that have different subcellular localization.

Protein type: Oncoprotein; EC 2.7.10.2; Protein kinase, tyrosine (non-receptor); Protein kinase, TK; Kinase, protein; TK group; Src family

Cellular Component: actin filament; caveola; extrinsic to internal side of plasma membrane; focal adhesion; lysosome

Molecular Function: non-membrane spanning protein tyrosine kinase activity; protein binding; protein-tyrosine kinase activity; receptor binding

Biological Process: cell differentiation; cytoskeleton organization and biogenesis; defense response to Gram-positive bacterium; innate immune response; negative regulation of apoptosis; peptidyl-tyrosine phosphorylation; phagocytosis; positive regulation of cell proliferation; protein amino acid autophosphorylation; regulation of cell proliferation; regulation of cell shape; regulation of phagocytosis; regulation of transcription factor activity; transmembrane receptor protein tyrosine kinase signaling pathway