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HIST1H1E Antibody (N-Term) Blocking Peptide

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS9220127

Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Acts also as a regulator of… More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
HIST1H1E, Blocking Peptide
Full Product Name
HIST1H1E Antibody (N-term) Blocking peptide
Product Gene Name
Product Synonym Gene Name
H1F4
Product Synonym Names
Histone H14; Histone H1b; Histone H1s-4; HIST1H1E; H1F4
Form/Format
Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
Specificity
The synthetic peptide sequence used to generate the antibody was selected from the N-term region of HIST1H1E. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Preparation and Storage
Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.
Antibody/Peptide Pairs
Molecular Weight
21,865 Da
OMIM
142220
Cellular Location
Nucleus. Chromosome. Note: Mainly localizes in heterochromatin. Dysplays a punctuate staining pattern in the nucleus

Other Notes

Small volumes of HIST1H1E blocking peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for HIST1H1E purchase

MBS9220127 is a blocking peptide targeting HIST1H1E. Also known as HIST1H1E Antibody (N-term) Blocking peptide.

Additional Details

NCBI/Uniprot data below describe general gene information for HIST1H1E. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
Histone H1.4
NCBI Official Synonym Full Names
histone cluster 1, H1e
NCBI Official Symbol
HIST1H1E
NCBI Official Synonym Symbols
H1E; H1.4; H1F4; H1s-4; dJ221C16.5
UniProt Protein Name
Histone H1.4
UniProt Synonym Protein Names
Histone H1b; Histone H1s-4
Protein Family
UniProt Gene Name
HIST1H1E
UniProt Synonym Gene Names
H1F4
UniProt Entry Name
H14_HUMAN
NCBI Protein Information
histone H1.4

NCBI Summary for HIST1H1E

Histones are basic nuclear proteins responsible for nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H1 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6. [provided by RefSeq, Aug 2015]
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UniProt Comments for HIST1H1E

H1E: Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Acts also as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation. Belongs to the histone H1/H5 family.

Protein type: DNA-binding

Chromosomal Location of Human Ortholog: 6p21.3

Cellular Component: nuclear heterochromatin; nucleus

Molecular Function: chromatin DNA binding; protein binding
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Organs/Tissues associated with HIST1H1E blocking peptide

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >2 publications with HIST1H1E and Brain
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