HMGB2 Antibody (Center) Blocking Peptide

This gene encodes a member of the non-histone chromosomal high mobility group protein family. The proteins of this family are chromatin-associated and ubiquitously distributed in the nucleus of higher eukaryotic cells. In vitro studies have demonstrated that this protein is able to efficiently bend DNA and form DNA circles. These studies suggest a role in facilitating cooperative interactions between cis-acting proteins by promoting DNA flexibility. This protein was also reported to be involved in the final ligation step in DNA end-joining processes of DNA double-strand breaks repair and V(D)J recombination. [provided by RefSeq, Jul 2008]

HMGB2: DNA binding proteins that associates with chromatin and has the ability to bend DNA. Binds preferentially single-stranded DNA. Involved in V(D)J recombination by acting as a cofactor of the RAG complex. Acts by stimulating cleavage and RAG protein binding at the 23 bp spacer of conserved recombination signal sequences (RSS). Belongs to the HMGB family.

Protein type: Nuclear receptor co-regulator; DNA-binding

Chromosomal Location of Human Ortholog: 4q31

Cellular Component: cell; condensed chromosome; cytoplasm; extracellular space; nuclear chromatin; nucleolus; nucleoplasm; nucleus; perinuclear region of cytoplasm; protein complex

Molecular Function: chemoattractant activity; damaged DNA binding; DNA bending activity; DNA binding; double-stranded DNA binding; drug binding; four-way junction DNA binding; protein binding; RAGE receptor binding; single-stranded DNA binding; transcription factor activity; transcription factor binding

Biological Process: defense response to Gram-negative bacterium; defense response to Gram-positive bacterium; DNA fragmentation during apoptosis; DNA geometric change; DNA ligation during DNA repair; DNA topological change; inflammatory response to antigenic stimulus; negative regulation of transcription, DNA-dependent; positive regulation of DNA binding; positive regulation of endothelial cell proliferation; positive regulation of erythrocyte differentiation; positive regulation of megakaryocyte differentiation; positive regulation of nuclease activity; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; regulation of neurogenesis; regulation of transcription from RNA polymerase II promoter; response to drug; response to lipopolysaccharide; V(D)J recombination