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IBTK Antibody (Center) Blocking Peptide

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS9217827

Acts as an inhibitor of BTK tyrosine kinase activity, thereby playing a role in B-cell development. Down-regulates BTK kinase activity, leading to interference with BTK-mediated calcium mobilization and NF-kappa-B-driven transcription. More details

$455 / 0.5 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
IBTK, Blocking Peptide
Full Product Name
IBTK Antibody (Center) Blocking peptide
Product Gene Name
Product Synonym Gene Name
BTKI; KIAA1417
Product Synonym Names
Inhibitor of Bruton tyrosine kinase; IBtk; IBTK; BTKI; KIAA1417
Form/Format
Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
Preparation and Storage
Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.
Antibody/Peptide Pairs
IBTK peptide (MBS9217827) is used for blocking the activity of IBTK antibody (MBS9212561)
Molecular Weight
26,314 Da
OMIM
606457
Cellular Location
Cytoplasm. Membrane; Peripheral membrane protein. Note: Translocates to the plasma membrane upon IgM stimulation
Tissue Location
Expressed in DeFew, HEK293T, HeLa and in Jurkat, MC3 and NB4 lymphoid cells (at protein level). Isoform 1 is the predominant isoform expressed in all examined tissues and cell lines. Highly expressed in hemopoietic tissues (fetal liver, spleen, lymph node, thymus, peripheral blood leukocytes and bone marrow). Weakly or not expressed in other tissues

Other Notes

Small volumes of IBTK blocking peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for IBTK purchase

MBS9217827 is a blocking peptide targeting IBTK. Also known as IBTK Antibody (Center) Blocking peptide.

Additional Details

NCBI/Uniprot data below describe general gene information for IBTK. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
Inhibitor of Bruton tyrosine kinase
NCBI Official Synonym Full Names
inhibitor of Bruton tyrosine kinase
NCBI Official Symbol
IBTK
NCBI Official Synonym Symbols
BTKI; BTBD26
UniProt Protein Name
Inhibitor of Bruton tyrosine kinase
UniProt Gene Name
IBTK
UniProt Synonym Gene Names
BTKI; KIAA1417; IBtk
UniProt Entry Name
IBTK_HUMAN
NCBI Protein Information
inhibitor of Bruton tyrosine kinase

NCBI Summary for IBTK

Bruton tyrosine kinase (BTK) is a protein tyrosine kinase that is expressed in B cells, macrophages, and neutrophils. The protein encoded by this gene binds to BTK and downregulates BTK's kinase activity. In addition, the encoded protein disrupts BTK-mediated calcium mobilization and negatively regulates the activation of nuclear factor-kappa-B-driven transcription. This gene has a pseudogene on chromosome 18. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2014]
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UniProt Comments for IBTK

IBTK: Acts as an inhibitor of BTK tyrosine kinase activity, thereby playing a role in B-cell development. Down-regulates BTK kinase activity, leading to interference with BTK-mediated calcium mobilization and NF-kappa-B-driven transcription. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Protein kinase, regulatory subunit

Chromosomal Location of Human Ortholog: 6q14.1

Cellular Component: cytoplasm; nucleoplasm

Molecular Function: protein kinase binding; protein tyrosine kinase inhibitor activity

Biological Process: negative regulation of protein amino acid phosphorylation; release of sequestered calcium ion into cytosol
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with IBTK blocking peptide

 Products by Pathway  Pathway Diagram
 BCR Signaling Pathway antibodies  BCR Signaling Pathway Diagram

Diseases associated with IBTK blocking peptide

 Disease Name  Pubmed Publications
 Inflammation Antibodies  >1 publications with IBTK and Inflammation
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