KCNN2 Blocking Peptide – Cat# MBS9622202

KCNN2 Blocking Peptide – The purity is >90%,tested by HPLC and MS. Purity

Name: KCNN2 Blocking Peptide; The purity is >90%,tested by HPLC and MS. Purity; MyBioSource
Brand: MyBioSource
SKU: MBS9622202
Price: 460 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS9622202

Blocking peptides are peptides that bind specifically to the target antibody and block antibody binding. These peptide usually contains the epitope recognized by the antibody. Antibodies bound to the blocking peptide no longer bind to the epitope on the… More details

$460 / 1 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

KCNN2, Blocking Peptide

Full Product Name

KCNN2 Blocking Peptide

Product Gene Name

KCNN2 blocking peptide

Form/Format

Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 10 mg/ml.

Purity/Purification

The purity is >90%,tested by HPLC and MS.

Preparation and Storage

Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Antibody/Peptide Pairs

KCNN2 peptide (MBS9622202) is used for blocking the activity of KCNN2 antibody (MBS9612258)

Molecular Weight

63,760 Da

OMIM

605879

Supply Chain Verification

Manufactured in a lab with traceable raw materials manufactured on site. Coordinated product portfolio of antibodies, pairs, conjugates, recombinant proteins, and immunoassay materials available, please inquire.

Notes

For phospho antibody, we provide phospho peptide (0.5mg) and non-phospho peptide (0.5mg)

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Applications Tested/Suitable for KCNN2 blocking peptide

Blocking/Control

Other Notes

Small volumes of KCNN2 blocking peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for KCNN2 purchase

MBS9622202 is a blocking peptide targeting KCNN2.

Additional Details

NCBI/Uniprot data below describe general gene information for KCNN2. It may not necessarily be applicable to this product.

NCBI GI #

578810350

NCBI GeneID

3781

NCBI Accession #

XP_006714676.1

UniProt Primary Accession #

Q9H2S1

UniProt Secondary Accession #

Q0VFZ4; Q6PJI0; Q6X2Y2; A6NF94

UniProt Related Accession #

Q9H2S1

GenBank Nucleotide #

XM_006714613.1

NCBI Official Full Name

small conductance calcium-activated potassium channel protein 2 isoform X1

NCBI Official Synonym Full Names

potassium intermediate/small conductance calcium-activated channel, subfamily N, member 2

NCBI Official Symbol

KCNN2

NCBI Official Synonym Symbols

SK2; hSK2; SKCA2; KCa2.2; SKCa 2

UniProt Protein Name

Small conductance calcium-activated potassium channel protein 2

UniProt Synonym Protein Names

KCa2.2

Protein Family

Small conductance calcium-activated potassium channel protein

UniProt Gene Name

KCNN2

UniProt Synonym Gene Names

SK2; SKCa 2; SKCa2

UniProt Entry Name

KCNN2_HUMAN

NCBI Protein Information

small conductance calcium-activated potassium channel protein 2; apamin-sensitive small-conductance Ca2+-activated potassium channel

NCBI Summary for KCNN2

Action potentials in vertebrate neurons are followed by an afterhyperpolarization (AHP) that may persist for several seconds and may have profound consequences for the firing pattern of the neuron. Each component of the AHP is kinetically distinct and is mediated by different calcium-activated potassium channels. The protein encoded by this gene is activated before membrane hyperpolarization and is thought to regulate neuronal excitability by contributing to the slow component of synaptic AHP. This gene is a member of the KCNN family of potassium channel genes. The encoded protein is an integral membrane protein that forms a voltage-independent calcium-activated channel with three other calmodulin-binding subunits. Alternate splicing of this gene results in multiple transcript variants. [provided by RefSeq, May 2013]

UniProt Comments for KCNN2

KCNN2: Forms a voltage-independent potassium channel activated by intracellular calcium. Activation is followed by membrane hyperpolarization. Thought to regulate neuronal excitability by contributing to the slow component of synaptic afterhyperpolarization. The channel is blocked by apamin. Belongs to the potassium channel KCNN family. KCa2.2/KCNN2 subfamily.

Protein type: Membrane protein, integral; Channel, potassium; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 5q22.3

Cellular Component: smooth endoplasmic reticulum; cell soma; T-tubule; plasma membrane; integral to membrane; dendritic spine; Z disc

Molecular Function: calmodulin binding; calcium-activated potassium channel activity; protein homodimerization activity; alpha-actinin binding; small conductance calcium-activated potassium channel activity

Biological Process: synaptic transmission; potassium ion transport

Research Articles on KCNN2

1. KCNN2 gene can have an important role in the development of coronary artery aneurysms in Kawasaki disease.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with KCNN2 blocking peptide

Reference Product	PubMed Publications
KCNN3 blocking peptide	>29 publications with KCNN2 and KCNN3
KCNN1 blocking peptide	>27 publications with KCNN2 and KCNN1
ACTN2 blocking peptide	>2 publications with KCNN2 and ACTN2

Pathways associated with KCNN2 blocking peptide

Products by Pathway	Pathway Diagram
BDNF Signaling Pathway antibodies	BDNF Signaling Pathway Diagram
Bile Secretion Pathway antibodies	Bile Secretion Pathway Diagram
Bile Secretion Pathway antibodies	Bile Secretion Pathway Diagram
Ca2+ Activated K+ Channels Pathway antibodies	Ca2+ Activated K+ Channels Pathway Diagram
Insulin Secretion Pathway antibodies	Insulin Secretion Pathway Diagram
Neuronal System Pathway antibodies	Neuronal System Pathway Diagram
Potassium Channels Pathway antibodies	Potassium Channels Pathway Diagram
Serotonergic Synapse Pathway antibodies	Serotonergic Synapse Pathway Diagram

Diseases associated with KCNN2 blocking peptide

Disease Name	Pubmed Publications
Arrhythmias, Cardiac Antibodies	>7 publications with KCNN2 and Arrhythmias, Cardiac
Disease Models, Animal Antibodies	>5 publications with KCNN2 and Disease Models, Animal
Neurobehavioral Manifestations Antibodies	>4 publications with KCNN2 and Neurobehavioral Manifestations
Learning Disorders Antibodies	>2 publications with KCNN2 and Learning Disorders
Pain Antibodies	>2 publications with KCNN2 and Pain
Inflammation Antibodies	>2 publications with KCNN2 and Inflammation
Hypotension Antibodies	>1 publications with KCNN2 and Hypotension
Liver Diseases Antibodies	>1 publications with KCNN2 and Liver Diseases
Mental Disorders Antibodies	>1 publications with KCNN2 and Mental Disorders
Hypertension Antibodies	>1 publications with KCNN2 and Hypertension

Organs/Tissues associated with KCNN2 blocking peptide

Organ/Tissue Name	Pubmed Publications
Brain Antibodies	>47 publications with KCNN2 and Brain
Ear Antibodies	>11 publications with KCNN2 and Ear
Kidney Antibodies	>8 publications with KCNN2 and Kidney
Adrenal Gland Antibodies	>3 publications with KCNN2 and Adrenal Gland
Prostate Antibodies	>2 publications with KCNN2 and Prostate
Embryonic Tissue Antibodies	>2 publications with KCNN2 and Embryonic Tissue