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KIRREL Blocking Peptide

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS544030

Antigenic Blocking Peptide Kin of IRRE-like protein 1Plays a significant role in the normal development and function of the glomerular permeability. Is a signaling protein that needs the presence of TEC kinases to fully trans-activate the transcription factor… More details

$315 / 0.25 mg +1 FREE 8GB USB
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Testing Data View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
KIRREL, Blocking Peptide
Full Product Name
KIRREL Peptide
Product Gene Name
Product Synonym Names
FLJ10845; Kin of IRRE like (Drosophila); Kin of IRRE like; Kin of irregular chiasm-like protein 1; Kirrel; MGC129542; MGC129543; NEPH 1; Nephrin like protein 1; Nephrin related antibody
Form/Format
Antigenic Blocking Peptide
Concentration
Quantity: 250 ug; Volume: 100 ul (lot specific)
Preparation and Storage
-20 degree C for long term storage
Antibody/Peptide Pairs
KIRREL peptide (MBS544030) is used for blocking the activity of KIRREL antibody (MBS542191)
Antibody/Peptide Pairs
KIRREL peptide (MBS544030) is used for blocking the activity of KIRREL antibody (MBS542192)
Molecular Weight
69,967 Da
Immunogen
Recombinant Neph1 protein.
Expression
Abundantly expressed in kidney. Specifically expressed in podocytes of kidney glomeruli.
Molecular Function
Myosin Binding
Structure
Interacts with TJP1/ZO-1 and with NPHS2/podocin (via the C-terminus). Interacts with NPHS1/nephrin (via the Ig-like domains); this interaction is dependent on KIRREL glycosylation. Homodimer (via the Ig-like domains). Interacts when tyrosine-phosphorylate
Subcellular Location
Cell membrane; Single-pass type I membrane protein
Applications Tested/Suitable for KIRREL blocking peptide
Immunocompetition, Immunodepletion
Application Notes for KIRREL blocking peptide
Confocal Microscopy||1:250
Immunocytochemistry: 1:250
Immunofluorescence: 1:250
Immunohistochemistry: 1:250
Western Blot: 1:250

Other Notes

Small volumes of KIRREL blocking peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for KIRREL purchase

MBS544030 is a blocking peptide targeting KIRREL. Also known as KIRREL Peptide.

Additional Details

NCBI/Uniprot data below describe general gene information for KIRREL. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
Kin of IRRE-like protein 1
NCBI Official Synonym Full Names
kin of IRRE like (Drosophila)
NCBI Official Symbol
Kirrel
NCBI Official Synonym Symbols
Neph1; Kirrel1; 6720469N11Rik
UniProt Protein Name
Kin of IRRE-like protein 1
UniProt Synonym Protein Names
Kin of irregular chiasm-like protein 1; Nephrin-like protein 1
UniProt Gene Name
Kirrel
UniProt Synonym Gene Names
Kirrel1; Neph1
UniProt Entry Name
KIRR1_MOUSE
NCBI Protein Information
kin of IRRE-like protein 1

UniProt Comments for KIRREL

KIRREL: Plays a significant role in the normal development and function of the glomerular permeability. Signaling protein that needs the presence of TEC kinases to fully trans-activate the transcription factor AP-1. Belongs to the immunoglobulin superfamily. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Cell adhesion; Membrane protein, integral

Cellular Component: cell projection membrane; dendritic shaft; integral to membrane; intercellular junction; lipid raft; membrane; perinuclear region of cytoplasm; plasma membrane

Molecular Function: myosin binding; protein binding

Biological Process: cell-cell adhesion; excretion; negative regulation of protein amino acid phosphorylation; positive regulation of actin filament polymerization
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

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