MCL1 Blocking Peptide – The purity is >90%,tested by HPLC and MS. Purity

Name: MCL1 Blocking Peptide; The purity is >90%,tested by HPLC and MS. Purity; MyBioSource
Brand: MyBioSource
SKU: MBS9616746
Price: 460 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS9616746

Blocking peptides are peptides that bind specifically to the target antibody and block antibody binding. These peptide usually contains the epitope recognized by the antibody. Antibodies bound to the blocking peptide no longer bind to the epitope on the… More details

$460 / 1 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

MCL1, Blocking Peptide

Full Product Name

MCL1 Blocking Peptide

Product Gene Name

MCL1 blocking peptide

Product Synonym Names

Bcl 2 related protein EAT/mcl1; Bcl-2-like protein 3; Bcl-2-related protein EAT/mcl1; BCL2 related; Bcl2-L-3; BCL2L3; EAT; Induced myeloid leukemia cell differentiation protein Mcl 1; Induced myeloid leukemia cell differentiation protein Mcl-1; MCL 1; MCL1; MCL1-ES; mcl1/EAT; MCL1_HUMAN; MCL1L; MCL1S; MGC104264; MGC1839; Myeloid Cell Leukemia 1; Myeloid cell leukemia ES; Myeloid cell leukemia sequence 1; Myeloid cell leukemia sequence 1 BCL2 related; Myeloid cell leukemia sequence 1 isoform 1; OTTHUMP00000032794; OTTHUMP00000032795; TM

Form/Format

Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 10 mg/ml.

Purity/Purification

The purity is >90%,tested by HPLC and MS.

Preparation and Storage

Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Antibody/Peptide Pairs

MCL1 peptide (MBS9616746) is used for blocking the activity of MCL1 antibody (MBS9613464)

Molecular Weight

37,337 Da

Chromosome Location

Chromosome: 1; NC_000001.10 (150547027..150552214, complement). Location: 1q21

OMIM

159552

Supply Chain Verification

Manufactured in a lab with traceable raw materials manufactured on site. Coordinated product portfolio of antibodies, pairs, conjugates, recombinant proteins, and immunoassay materials available, please inquire.

Notes

For phospho antibody, we provide phospho peptide (0.5mg) and non-phospho peptide (0.5mg)

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Applications Tested/Suitable for MCL1 blocking peptide

Blocking/Control

Other Notes

Small volumes of MCL1 blocking peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for MCL1 purchase

MBS9616746 is a blocking peptide targeting MCL1.

Additional Details

NCBI/Uniprot data below describe general gene information for MCL1. It may not necessarily be applicable to this product.

NCBI GI #

309747067

NCBI GeneID

4170

NCBI Accession #

NP_001184249.1

UniProt Primary Accession #

Q07820

UniProt Secondary Accession #

Q9HD91; Q9NRQ3; Q9NRQ4; Q9UHR7; Q9UHR8; Q9UHR9; Q9UNJ1; B2R6B2; D3DV03; D3DV04

UniProt Related Accession #

Q07820

GenBank Nucleotide #

NM_001197320.1

NCBI Official Full Name

induced myeloid leukemia cell differentiation protein Mcl-1 isoform 3

NCBI Official Synonym Full Names

myeloid cell leukemia sequence 1 (BCL2-related)

NCBI Official Symbol

MCL1

NCBI Official Synonym Symbols

TM; EAT; MCL1L; MCL1S; Mcl-1; BCL2L3; MCL1-ES; bcl2-L-3; mcl1/EAT

UniProt Protein Name

Induced myeloid leukemia cell differentiation protein Mcl-1

UniProt Synonym Protein Names

Bcl-2-like protein 3; Bcl2-L-3; Bcl-2-related protein EAT/mcl1; mcl1/EAT

Protein Family

Induced myeloid leukemia cell differentiation protein

UniProt Gene Name

MCL1

UniProt Synonym Gene Names

BCL2L3; Bcl2-L-3

UniProt Entry Name

MCL1_HUMAN

NCBI Protein Information

induced myeloid leukemia cell differentiation protein Mcl-1; bcl-2-like protein 3; myeloid cell leukemia ES; bcl-2-related protein EAT/mcl1

NCBI Summary for MCL1

This gene encodes an anti-apoptotic protein, which is a member of the Bcl-2 family. Alternative splicing results in multiple transcript variants. The longest gene product (isoform 1) enhances cell survival by inhibiting apoptosis while the alternatively spliced shorter gene products (isoform 2 and isoform 3) promote apoptosis and are death-inducing. [provided by RefSeq, Oct 2010]

UniProt Comments for MCL1

MCL1: a myeloid cell leukemia protein of the Bcl-2 family of proteins. Two alternatively spliced transcripts encoding distinct isoforms have been identified. The longer gene product (isoform 1) enhances cell survival by inhibiting apoptosis while the alternatively spliced shorter gene product (isoform 2) promotes apoptosis and is death-inducing.

Protein type: Membrane protein, integral; Mitochondrial; Channel, misc.; Inhibitor; Apoptosis

Chromosomal Location of Human Ortholog: 1q21

Cellular Component: nucleoplasm; mitochondrial outer membrane; mitochondrion; membrane; mitochondrial matrix; cytoplasm; integral to membrane; cytosol; nucleus

Molecular Function: protein binding; protein homodimerization activity; protein heterodimerization activity; protein channel activity; BH3 domain binding

Biological Process: apoptotic mitochondrial changes; DNA damage response, signal transduction resulting in induction of apoptosis; response to cytokine stimulus; multicellular organismal development; cellular homeostasis; cell fate determination

Research Articles on MCL1

1. It possesses an ability to downregulate the antiapoptotic Mcl-1 protein.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with MCL1 blocking peptide

Reference Product	PubMed Publications
BAX blocking peptide	>41 publications with MCL1 and BAX
CASP3 blocking peptide	>33 publications with MCL1 and CASP3
BCL2L1 blocking peptide	>33 publications with MCL1 and BCL2L1
PMAIP1 blocking peptide	>9 publications with MCL1 and PMAIP1
BID blocking peptide	>8 publications with MCL1 and BID
BAD blocking peptide	>8 publications with MCL1 and BAD
BAK1 blocking peptide	>7 publications with MCL1 and BAK1
BIK blocking peptide	>5 publications with MCL1 and BIK
BBC3 blocking peptide	>5 publications with MCL1 and BBC3
PCNA blocking peptide	>5 publications with MCL1 and PCNA

Pathways associated with MCL1 blocking peptide

Products by Pathway	Pathway Diagram
Apoptosis Pathway antibodies	Apoptosis Pathway Diagram
Apoptosis Modulation And Signaling Pathway antibodies	Apoptosis Modulation And Signaling Pathway Diagram
Direct P53 Effectors Pathway antibodies	Direct P53 Effectors Pathway Diagram
E2F Transcription Factor Network Pathway antibodies	E2F Transcription Factor Network Pathway Diagram
HIF-1-alpha Transcription Factor Network Pathway antibodies	HIF-1-alpha Transcription Factor Network Pathway Diagram
IL-7 Signaling Pathway antibodies	IL-7 Signaling Pathway Diagram
IL6-mediated Signaling Events Pathway antibodies	IL6-mediated Signaling Events Pathway Diagram
PI3K-Akt Signaling Pathway antibodies	PI3K-Akt Signaling Pathway Diagram
PI3K-Akt Signaling Pathway antibodies	PI3K-Akt Signaling Pathway Diagram

Diseases associated with MCL1 blocking peptide

Disease Name	Pubmed Publications
Neoplasms Antibodies	>133 publications with MCL1 and Neoplasms
Multiple Myeloma Antibodies	>15 publications with MCL1 and Multiple Myeloma
Drug Toxicity Antibodies	>13 publications with MCL1 and Drug Toxicity
Lung Diseases Antibodies	>12 publications with MCL1 and Lung Diseases
Necrosis Antibodies	>11 publications with MCL1 and Necrosis
Adenocarcinoma Antibodies	>10 publications with MCL1 and Adenocarcinoma
Lung Neoplasms Antibodies	>10 publications with MCL1 and Lung Neoplasms
Nervous System Diseases Antibodies	>6 publications with MCL1 and Nervous System Diseases
Liver Diseases Antibodies	>5 publications with MCL1 and Liver Diseases
Sarcoma Antibodies	>5 publications with MCL1 and Sarcoma

Organs/Tissues associated with MCL1 blocking peptide

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>38 publications with MCL1 and Blood
Bone Antibodies	>22 publications with MCL1 and Bone
Lung Antibodies	>19 publications with MCL1 and Lung
Bone Marrow Antibodies	>14 publications with MCL1 and Bone Marrow
Vascular Antibodies	>12 publications with MCL1 and Vascular
Brain Antibodies	>10 publications with MCL1 and Brain
Liver Antibodies	>6 publications with MCL1 and Liver
Lymph Node Antibodies	>6 publications with MCL1 and Lymph Node
Lymph Antibodies	>5 publications with MCL1 and Lymph
Heart Antibodies	>5 publications with MCL1 and Heart