Phospho-MEF2A (Thr312) Blocking Peptide – The purity is >90%,tested by HPLC and MS. Purity

The protein encoded by this gene is a DNA-binding transcription factor that activates many muscle-specific, growth factor-induced, and stress-induced genes. The encoded protein can act as a homodimer or as a heterodimer and is involved in several cellular processes, including muscle development, neuronal differentiation, cell growth control, and apoptosis. Defects in this gene could be a cause of autosomal dominant coronary artery disease 1 with myocardial infarction (ADCAD1). Several transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jan 2010]

MEF2A: a myocyte-specific enhancing transcription factor which binds specifically to the MEF2 element present in the regulatory regions of many, if not all, muscle-specific genes. A member of the MADS gene family that also includes several homeotic genes and other transcription factors, all of which share a conserved DNA-binding domain. Five alternatively spliced isoforms have been reported.

Protein type: DNA-binding; Transcription factor; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 15q26

Cellular Component: nucleoplasm; transcription factor complex; cytoplasm; nuclear chromatin; nucleus

Molecular Function: RNA polymerase II transcription factor activity, enhancer binding; histone acetyltransferase binding; protein binding; transcription activator binding; protein heterodimerization activity; sequence-specific DNA binding; histone deacetylase binding; chromatin binding; SMAD binding; transcription factor activity; protein kinase binding

Biological Process: transcription from RNA polymerase II promoter; muscle development; ventricular cardiac myofibril development; nerve growth factor receptor signaling pathway; apoptosis; heart development; stress-activated MAPK cascade; toll-like receptor 3 signaling pathway; negative regulation of transcription from RNA polymerase II promoter; toll-like receptor 10 signaling pathway; toll-like receptor 5 signaling pathway; mitochondrial genome maintenance; toll-like receptor 4 signaling pathway; transcription, DNA-dependent; MyD88-independent toll-like receptor signaling pathway; dendrite morphogenesis; MAPKKK cascade; toll-like receptor 2 signaling pathway; mitochondrion distribution; MyD88-dependent toll-like receptor signaling pathway; muscle cell differentiation; toll-like receptor signaling pathway; positive regulation of muscle cell differentiation; innate immune response; positive regulation of transcription from RNA polymerase II promoter; toll-like receptor 9 signaling pathway

Disease: Coronary Artery Disease, Autosomal Dominant, 1