MEF2C Blocking Peptide

MEF2C: transcription factor of the MADS family which binds specifically to the MEF2 element present in the regulatory regions of many muscle-specific genes. May be involved in myogenesis, neurogenesis and in the development of cortical architecture. Three splice-variant isoforms have been described.

Protein type: Transcription factor; DNA-binding

Cellular Component: nucleoplasm; sarcomere; protein complex; intracellular membrane-bound organelle; cytoplasm; nuclear speck; intracellular; nucleus; cytosol

Molecular Function: protein dimerization activity; RNA polymerase II transcription factor activity, enhancer binding; protein binding; miRNA binding; transcription activator binding; DNA binding; AT DNA binding; sequence-specific DNA binding; protein heterodimerization activity; histone deacetylase binding; chromatin binding; transcription factor activity

Biological Process: cardiac muscle hypertrophy; multicellular organismal development; positive regulation of transcription, DNA-dependent; heart development; regulation of neurotransmitter secretion; regulation of synaptic plasticity; cardiac muscle cell differentiation; neuron differentiation; positive regulation of MAP kinase activity; B cell receptor signaling pathway; regulation of neuron apoptosis; positive regulation of B cell proliferation; negative regulation of ossification; chondrocyte differentiation; negative regulation of neuron apoptosis; endochondral ossification; positive regulation of cardiac muscle cell proliferation; nervous system development; skeletal muscle development; cell fate commitment; transcription, DNA-dependent; monocyte differentiation; positive regulation of skeletal muscle development; muscle cell fate determination; regulation of synaptogenesis; neuron development; smooth muscle cell differentiation; positive regulation of transcription from RNA polymerase II promoter; B cell proliferation; transcription from RNA polymerase II promoter; regulation of synaptic transmission, glutamatergic; apoptosis; ventricular cardiac muscle cell differentiation; neuron migration; regulation of synaptic activity; palate development; negative regulation of transcription from RNA polymerase II promoter; learning and/or memory; B cell homeostasis; regulation of transcription, DNA-dependent; melanocyte differentiation; regulation of megakaryocyte differentiation; germinal center formation; neural crest cell differentiation; heart looping; cell differentiation; negative regulation of epithelial cell proliferation; blood vessel development; MAPKKK cascade; embryonic viscerocranium morphogenesis; positive regulation of bone mineralization; positive regulation of myoblast differentiation; humoral immune response; regulation of germinal center formation; embryonic skeletal morphogenesis; osteoblast differentiation; positive regulation of osteoblast differentiation; neuron morphogenesis during differentiation; blood vessel remodeling; platelet formation; regulation of excitatory postsynaptic membrane potential; positive regulation of neuron differentiation