MVP Antibody (C-Term) Blocking Peptide

Name: MVP Antibody (C-Term) Blocking Peptide; MyBioSource
Brand: MyBioSource
SKU: MBS9225965
Price: 455 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS9225965

Required for normal vault structure. Vaults are multi- subunit structures that may act as scaffolds for proteins involved in signal transduction. Vaults may also play a role in nucleo- cytoplasmic transport. Down-regulates INFG-mediated STAT1 signaling and… More details

$455 / 0.5 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

MVP, Blocking Peptide

Full Product Name

MVP Antibody (C-term) Blocking Peptide

Product Gene Name

MVP blocking peptide

Product Synonym Gene Name

LRP

Product Synonym Names

Major vault protein; MVP; Lung resistance-related protein; MVP; LRP

Form/Format

The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.

Specificity

The synthetic peptide sequence used to generate the antibody was selected from the C-term region of human MVP. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.

Preparation and Storage

Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Antibody/Peptide Pairs

MVP peptide (MBS9225965) is used for blocking the activity of MVP antibody (MBS9214224)

Molecular Weight

99,327 Da

OMIM

605088

Cellular Location

Cytoplasm. Nucleus, nuclear pore complex. Note: 5% found in the nuclear pore complex. Translocates from the nucleus to the cytoplasm upon EGF treatment

Tissue Location

Present in most normal tissues. Higher expression observed in epithelial cells with secretory and excretory functions, as well as in cells chronically exposed to xenobiotics, such as bronchial cells and cells lining the intestine. Overexpressed in many multidrug-resistant cancer cells

Other Notes

Small volumes of MVP blocking peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for MVP purchase

MBS9225965 is a blocking peptide targeting MVP. Also known as MVP Antibody (C-term) Blocking Peptide.

Additional Details

NCBI/Uniprot data below describe general gene information for MVP. It may not necessarily be applicable to this product.

NCBI GI #

19913412

NCBI GeneID

9961

NCBI Accession #

NP_005106

UniProt Primary Accession #

Q14764

UniProt Secondary Accession #

Q96BG4; Q9BPW6; Q9BQT1; Q9UBD1

UniProt Related Accession #

Q14764

GenBank Nucleotide #

NM_005115.4

NCBI Official Full Name

major vault protein isoform 1

NCBI Official Synonym Full Names

major vault protein

NCBI Official Symbol

MVP

NCBI Official Synonym Symbols

LRP; VAULT1

UniProt Protein Name

Major vault protein

UniProt Synonym Protein Names

Lung resistance-related protein

Protein Family

Hyperpolarization-activated voltage-gated potassium channel

UniProt Gene Name

MVP

UniProt Synonym Gene Names

LRP; MVP

UniProt Entry Name

MVP_HUMAN

NCBI Protein Information

major vault protein

NCBI Summary for MVP

This gene encodes the major component of the vault complex. Vaults are multi-subunit ribonucleoprotein structures that may be involved in nucleo-cytoplasmic transport. The encoded protein may play a role in multiple cellular processes by regulating the MAP kinase, JAK/STAT and phosphoinositide 3-kinase/Akt signaling pathways. The encoded protein also plays a role in multidrug resistance, and expression of this gene may be a prognostic marker for several types of cancer. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, May 2012]

UniProt Comments for MVP

MVP: Required for normal vault structure. Vaults are multi- subunit structures that may act as scaffolds for proteins involved in signal transduction. Vaults may also play a role in nucleo- cytoplasmic transport. Down-regulates INFG-mediated STAT1 signaling and subsequent activation of JAK. Down-regulates SRC activity and signaling through MAP kinases.

Protein type: RNA-binding

Chromosomal Location of Human Ortholog: 16p11.2

Cellular Component: cytoplasm; cytoskeleton; membrane; nucleus; perinuclear region of cytoplasm

Molecular Function: protein binding; protein kinase binding; protein phosphatase binding

Biological Process: negative regulation of protein amino acid autophosphorylation

Research Articles on MVP

1. NSCLCs [ non-small cell lung cancer ] expressing P-gp [P-glycoprotein ]/LRP [ lung resistance-related protein] bear the EGFR [epidermal growth factor receptor] mutation in exon 19 or 21 easily.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with MVP blocking peptide

Reference Product	PubMed Publications
TEP1 blocking peptide	>21 publications with MVP and TEP1
ABCB1 blocking peptide	>14 publications with MVP and ABCB1
PTEN blocking peptide	>8 publications with MVP and PTEN
TP53 blocking peptide	>5 publications with MVP and TP53
PTPN11 blocking peptide	>1 publications with MVP and PTPN11
RFWD2 blocking peptide	>1 publications with MVP and RFWD2
PARP4 blocking peptide	>1 publications with MVP and PARP4

Diseases associated with MVP blocking peptide

Disease Name	Pubmed Publications
Heart Diseases Antibodies	>808 publications with MVP and Heart Diseases
Lung Diseases Antibodies	>155 publications with MVP and Lung Diseases
Lung Neoplasms Antibodies	>151 publications with MVP and Lung Neoplasms
Hypertension Antibodies	>34 publications with MVP and Hypertension
Fibrosis Antibodies	>33 publications with MVP and Fibrosis
Disease Models, Animal Antibodies	>33 publications with MVP and Disease Models, Animal
Neoplasm Metastasis Antibodies	>33 publications with MVP and Neoplasm Metastasis
Hypertrophy Antibodies	>30 publications with MVP and Hypertrophy
Breast Neoplasms Antibodies	>27 publications with MVP and Breast Neoplasms
Inflammation Antibodies	>22 publications with MVP and Inflammation

Organs/Tissues associated with MVP blocking peptide

Organ/Tissue Name	Pubmed Publications
Heart Antibodies	>598 publications with MVP and Heart
Blood Antibodies	>292 publications with MVP and Blood
Lung Antibodies	>223 publications with MVP and Lung
Vascular Antibodies	>131 publications with MVP and Vascular
Brain Antibodies	>93 publications with MVP and Brain
Muscle Antibodies	>70 publications with MVP and Muscle
Bone Antibodies	>67 publications with MVP and Bone
Connective Tissue Antibodies	>47 publications with MVP and Connective Tissue
Liver Antibodies	>39 publications with MVP and Liver
Bladder Antibodies	>35 publications with MVP and Bladder