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MX1 Antibody (Center) Blocking Peptide

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS9221535

Interferon-induced dynamin-like GTPase with antiviral activity against a wide range of RNA viruses and some DNA viruses. Its target viruses include negative-stranded RNA viruses and HBV through binding and inactivation of their ribonucleocapsid. May also… More details

$455 / 0.5 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
MX1, Blocking Peptide
Full Product Name
MX1 Antibody (Center) Blocking Peptide
Product Gene Name
MX1 blocking peptide
Product Synonym Names
Interferon-induced GTP-binding protein Mx1; Interferon-induced protein p78; IFI-78K; Interferon-regulated resistance GTP-binding protein MxA; Myxoma resistance protein 1; Myxovirus resistance protein 1; Interferon-induced GTP-binding protein Mx1; N-terminally processed; MX1
Form/Format
Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
Preparation and Storage
Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.
Antibody/Peptide Pairs
MX1 peptide (MBS9221535) is used for blocking the activity of MX1 antibody (MBS9201668)
Molecular Weight
55,661 Da
OMIM
147150
Cellular Location
Cytoplasm. Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, perinuclear region. Note: Binds preferentially to negatively charged phospholipids. Colocalizes with CCHFV protein N in the perinuclear region

Other Notes

Small volumes of MX1 blocking peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for MX1 purchase

MBS9221535 is a blocking peptide targeting MX1. Also known as MX1 Antibody (Center) Blocking Peptide.

Additional Details

NCBI/Uniprot data below describe general gene information for MX1. It may not necessarily be applicable to this product.

NCBI GI #
251757499
NCBI GeneID
4599
NCBI Accession #
P20591.4
UniProt Primary Accession #
P20591
UniProt Secondary Accession #
Q86YP5; Q96CI3; B2RDA5; B3KU10; C9IYV7; C9J8D6; C9JN19; C9JN88; C9JUL1; C9JZS6; D3DSI8
UniProt Related Accession #
P20591
NCBI Official Full Name
Interferon-induced GTP-binding protein Mx1
NCBI Official Synonym Full Names
MX dynamin like GTPase 1
NCBI Official Symbol
MX1
NCBI Official Synonym Symbols
MX; MxA; IFI78; IFI-78K
UniProt Protein Name
Interferon-induced GTP-binding protein Mx1
UniProt Synonym Protein Names
Interferon-induced protein p78; IFI-78K
Protein Family
Interferon-induced GTP-binding protein
UniProt Gene Name
MX1
UniProt Synonym Gene Names
IFI-78K
UniProt Entry Name
MX1_HUMAN
NCBI Protein Information
interferon-induced GTP-binding protein Mx1

NCBI Summary for MX1

This gene encodes a guanosine triphosphate (GTP)-metabolizing protein that participates in the cellular antiviral response. The encoded protein is induced by type I and type II interferons and antagonizes the replication process of several different RNA and DNA viruses. There is a related gene located adjacent to this gene on chromosome 21, and there are multiple pseudogenes located in a cluster on chromosome 4. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]
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UniProt Comments for MX1

MX1: Dynamin-like GTPase acting as a cell-autonomous host restriction factor against many viral pathogens. Shows activity against influenza viruses, rhabdovirus VSV, bunyavirus LACV, Thogoto virus, measles virus, Hantaan virus, Coxsackie virus CVB, Rift Valley fever virus RVFV, hepatitis B virus HBV, and Crimean- Congo hemorrhagic fever virus CCHFV. Belongs to the dynamin family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Apoptosis; Hydrolase

Chromosomal Location of Human Ortholog: 21q22.3

Cellular Component: cytoplasm; cytosol; nuclear membrane; perinuclear region of cytoplasm

Molecular Function: protein binding

Biological Process: apoptosis; defense response; innate immune response; negative regulation of viral genome replication; response to virus; signal transduction
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Research Articles on MX1

1. This study demonstrated that MxA mRNA expression of interferon beta response in multiple sclerosis patients.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with MX1 blocking peptide

 Reference Product  PubMed Publications
 ISG15 blocking peptide  >78 publications with MX1 and ISG15
 OAS1 blocking peptide  >53 publications with MX1 and OAS1
 IFIT1 blocking peptide  >32 publications with MX1 and IFIT1
 STAT2 blocking peptide  >24 publications with MX1 and STAT2
 OAS2 blocking peptide  >17 publications with MX1 and OAS2
 OASL blocking peptide  >13 publications with MX1 and OASL
 IFIT2 blocking peptide  >11 publications with MX1 and IFIT2
 ISG20 blocking peptide  >4 publications with MX1 and ISG20
 RNASEL blocking peptide  >3 publications with MX1 and RNASEL
 OAS3 blocking peptide  >2 publications with MX1 and OAS3

Pathways associated with MX1 blocking peptide

 Products by Pathway  Pathway Diagram
 Antiviral Mechanism By IFN-stimulated Genes Pathway antibodies  Antiviral Mechanism By IFN-stimulated Genes Pathway Diagram
 Cytokine Signaling In Immune System Pathway antibodies  Cytokine Signaling In Immune System Pathway Diagram
 ISG15 Antiviral Mechanism Pathway antibodies  ISG15 Antiviral Mechanism Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Influenza A Pathway antibodies  Influenza A Pathway Diagram
 Influenza A Pathway antibodies  Influenza A Pathway Diagram
 Interferon Signaling Pathway antibodies  Interferon Signaling Pathway Diagram
 Interferon Alpha/beta Signaling Pathway antibodies  Interferon Alpha/beta Signaling Pathway Diagram
 Measles Pathway antibodies  Measles Pathway Diagram
 Measles Pathway antibodies  Measles Pathway Diagram

Diseases associated with MX1 blocking peptide

 Disease Name  Pubmed Publications
 Influenza, Human Antibodies  >140 publications with MX1 and Influenza, Human
 Nervous System Diseases Antibodies  >109 publications with MX1 and Nervous System Diseases
 Liver Diseases Antibodies  >101 publications with MX1 and Liver Diseases
 Inflammation Antibodies  >63 publications with MX1 and Inflammation
 Necrosis Antibodies  >51 publications with MX1 and Necrosis
 Fever Antibodies  >39 publications with MX1 and Fever
 Cardiovascular Diseases Antibodies  >21 publications with MX1 and Cardiovascular Diseases
 Influenza in Birds Antibodies  >19 publications with MX1 and Influenza in Birds
 Adenocarcinoma Antibodies  >18 publications with MX1 and Adenocarcinoma
 Breast Neoplasms Antibodies  >18 publications with MX1 and Breast Neoplasms

Organs/Tissues associated with MX1 blocking peptide

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >307 publications with MX1 and Blood
 Liver Antibodies  >118 publications with MX1 and Liver
 Bone Antibodies  >59 publications with MX1 and Bone
 Lung Antibodies  >59 publications with MX1 and Lung
 Skin Antibodies  >49 publications with MX1 and Skin
 Kidney Antibodies  >46 publications with MX1 and Kidney
 Brain Antibodies  >44 publications with MX1 and Brain
 Vascular Antibodies  >34 publications with MX1 and Vascular
 Spleen Antibodies  >29 publications with MX1 and Spleen
 Heart Antibodies  >24 publications with MX1 and Heart
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