NCK1 Antibody (N-Term) Blocking Peptide

Name: NCK1 Antibody (N-Term) Blocking Peptide; MyBioSource
Brand: MyBioSource
SKU: MBS9227871
Price: 455 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS9227871

Adapter protein which associates with tyrosine- phosphorylated growth factor receptors, such as KDR and PDGFRB, or their cellular substrates. Maintains low levels of EIF2S1 phosphorylation by promoting its dephosphorylation by PP1. Plays a role in the DNA… More details

$455 / 0.5 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

NCK1, Blocking Peptide

Full Product Name

NCK1 Antibody (N-term) Blocking Peptide

Product Gene Name

NCK1 blocking peptide

Product Synonym Gene Name

NCK

Product Synonym Names

Cytoplasmic protein NCK1; NCK adaptor protein 1; Nck-1; SH2/SH3 adaptor protein NCK-alpha; NCK1; NCK

Form/Format

Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.

Specificity

The synthetic peptide sequence used to generate the antibody was selected from the N-term region of human NCK1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.

Preparation and Storage

Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Antibody/Peptide Pairs

NCK1 peptide (MBS9227871) is used for blocking the activity of NCK1 antibody (MBS9208377)

Molecular Weight

35,511 Da

OMIM

600508

Cellular Location

Cytoplasm. Endoplasmic reticulum. Nucleus. Note: Mostly cytoplasmic, but shuttles between the cytoplasm and the nucleus. Import into the nucleus requires the interaction with SOCS7. Predominantly nuclear following genotoxic stresses, such as UV irradiation, hydroxyurea or mitomycin C treatments

Other Notes

Small volumes of NCK1 blocking peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for NCK1 purchase

MBS9227871 is a blocking peptide targeting NCK1. Also known as NCK1 Antibody (N-term) Blocking Peptide.

Additional Details

NCBI/Uniprot data below describe general gene information for NCK1. It may not necessarily be applicable to this product.

NCBI GI #

127962

NCBI GeneID

4690

NCBI Accession #

P16333.1

UniProt Primary Accession #

P16333

UniProt Secondary Accession #

B7Z751; D3DNE3

UniProt Related Accession #

P16333

NCBI Official Full Name

Cytoplasmic protein NCK1

NCBI Official Synonym Full Names

NCK adaptor protein 1

NCBI Official Symbol

NCK1

NCBI Official Synonym Symbols

NCK; nck-1; NCKalpha

UniProt Protein Name

Cytoplasmic protein NCK1

UniProt Synonym Protein Names

NCK adaptor protein 1; Nck-1; SH2/SH3 adaptor protein NCK-alpha

Protein Family

Cytoplasmic protein

UniProt Gene Name

NCK1

UniProt Synonym Gene Names

NCK; Nck-1

UniProt Entry Name

NCK1_HUMAN

NCBI Protein Information

cytoplasmic protein NCK1

NCBI Summary for NCK1

The protein encoded by this gene is one of the signaling and transforming proteins containing Src homology 2 and 3 (SH2 and SH3) domains. It is located in the cytoplasm and is an adaptor protein involved in transducing signals from receptor tyrosine kinases to downstream signal recipients such as RAS. Alternatively spliced transcript variants encoding different isoforms have been found. [provided by RefSeq, Jun 2010]

UniProt Comments for NCK1

NCK1: adapter protein containing Src homology 2 and 3 (SH2 and SH3) domains. Transduces signals from tyrosine-phosphorylated growth factor receptors to their cellular substrates.

Protein type: Adaptor/scaffold; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 3q21

Cellular Component: cytoplasm; cytosol; endoplasmic reticulum; plasma membrane; protein phosphatase type 1 complex; ribosome; trans-Golgi network

Molecular Function: ARF guanyl-nucleotide exchange factor activity; protein binding; protein binding, bridging; protein kinase inhibitor activity; receptor binding; receptor tyrosine kinase binding

Biological Process: negative regulation of peptidyl-serine phosphorylation; positive regulation of actin filament polymerization; positive regulation of T cell proliferation; positive regulation of transcription from RNA polymerase II promoter; T cell activation; T cell receptor signaling pathway; vascular endothelial growth factor receptor signaling pathway; vesicle-mediated transport

Research Articles on NCK1

1. Results demonstrate that Nck acts as an important hub integrating angiogenic cues with cytoskeletal changes that enable endothelial apical-basal polarization and lumen formation.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with NCK1 blocking peptide

Reference Product	PubMed Publications
EGFR blocking peptide	>2 publications with NCK1 and EGFR
PDGFRB blocking peptide	>2 publications with NCK1 and PDGFRB
WASL blocking peptide	>1 publications with NCK1 and WASL
CBL blocking peptide	>1 publications with NCK1 and CBL
PAK1 blocking peptide	>1 publications with NCK1 and PAK1

Pathways associated with NCK1 blocking peptide

Products by Pathway	Pathway Diagram
Activation Of Rac Pathway antibodies	Activation Of Rac Pathway Diagram
Adaptive Immune System Pathway antibodies	Adaptive Immune System Pathway Diagram
Angiopoietin Receptor Tie2-mediated Signaling Pathway antibodies	Angiopoietin Receptor Tie2-mediated Signaling Pathway Diagram
Antigen Activates B Cell Receptor (BCR) Leading To Generation Of Second Messengers Pathway antibodies	Antigen Activates B Cell Receptor (BCR) Leading To Generation Of Second Messengers Pathway Diagram
Arf6 Signaling Events Pathway antibodies	Arf6 Signaling Events Pathway Diagram
Axon Guidance Pathway antibodies	Axon Guidance Pathway Diagram
Axon Guidance Pathway antibodies	Axon Guidance Pathway Diagram
Axon Guidance Pathway antibodies	Axon Guidance Pathway Diagram
B Cell Receptor Signaling Pathway antibodies	B Cell Receptor Signaling Pathway Diagram
BDNF Signaling Pathway antibodies	BDNF Signaling Pathway Diagram

Diseases associated with NCK1 blocking peptide

Disease Name	Pubmed Publications
Carcinoma, Hepatocellular Antibodies	>5 publications with NCK1 and Carcinoma, Hepatocellular
Liver Diseases Antibodies	>4 publications with NCK1 and Liver Diseases
Kidney Diseases Antibodies	>4 publications with NCK1 and Kidney Diseases
Proteinuria Antibodies	>3 publications with NCK1 and Proteinuria
Fever Antibodies	>2 publications with NCK1 and Fever
Nervous System Diseases Antibodies	>2 publications with NCK1 and Nervous System Diseases
Neoplasm Metastasis Antibodies	>2 publications with NCK1 and Neoplasm Metastasis
Pain Antibodies	>1 publications with NCK1 and Pain
Atrophy Antibodies	>1 publications with NCK1 and Atrophy
Lung Neoplasms Antibodies	>1 publications with NCK1 and Lung Neoplasms

Organs/Tissues associated with NCK1 blocking peptide

Organ/Tissue Name	Pubmed Publications
Eye Antibodies	>1 publications with NCK1 and Eye
Pancreas Antibodies	>1 publications with NCK1 and Pancreas
Lung Antibodies	>1 publications with NCK1 and Lung