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NKCC2 Blocking Peptide – The purity is >90%,tested by HPLC and MS. Purity

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS9621376

Blocking peptides are peptides that bind specifically to the target antibody and block antibody binding. These peptide usually contains the epitope recognized by the antibody. Antibodies bound to the blocking peptide no longer bind to the epitope on the… More details

$460 / 1 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
NKCC2, Blocking Peptide
Full Product Name
NKCC2 Blocking Peptide
Product Gene Name
NKCC2 blocking peptide
Product Synonym Gene Name
SLC12A1
Product Synonym Names
BSC1; Bumetanide sensitive sodium 3; Bumetanide-sensitive sodium-(potassium)-chloride cotransporter 2; Kidney specific Na K Cl symporter; Kidney-specific Na-K-Cl symporter; MGC48843; Na K 2Cl cotransporter; NKCC2; potassiumchloride cotransporter 2; S12A1_HUMAN; Slc12a1; sodium potassium chloride cotransporter 2; solute carrier family 12 (sodium/potassium/chloride transporters); Solute carrier family 12 member 1
Form/Format
Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 10 mg/ml.
Purity/Purification
The purity is >90%,tested by HPLC and MS.
Preparation and Storage
Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.
Antibody/Peptide Pairs
NKCC2 peptide (MBS9621376) is used for blocking the activity of NKCC2 antibody (MBS9611423)
Molecular Weight
– Da
OMIM
gene 601678
Supply Chain Verification
Manufactured in a lab with traceable raw materials manufactured on site. Coordinated product portfolio of antibodies, pairs, conjugates, recombinant proteins, and immunoassay materials available, please inquire.
Notes
For phospho antibody, we provide phospho peptide (0.5mg) and non-phospho peptide (0.5mg)
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Applications Tested/Suitable for NKCC2 blocking peptide
Blocking/Control

Other Notes

Small volumes of NKCC2 blocking peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for NKCC2 purchase

MBS9621376 is a blocking peptide targeting NKCC2.

Additional Details

NCBI/Uniprot data below describe general gene information for NKCC2. It may not necessarily be applicable to this product.

NCBI GI #
212276464
NCBI GeneID
6557
NCBI Accession #
Q13621.2
UniProt Primary Accession #
Q13621
UniProt Secondary Accession #
A8JYA2; E9PDW4
UniProt Related Accession #
Q13621
NCBI Official Full Name
Solute carrier family 12 member 1
NCBI Official Synonym Full Names
solute carrier family 12 (sodium/potassium/chloride transporter), member 1
NCBI Official Symbol
SLC12A1
NCBI Official Synonym Symbols
BSC1; NKCC2
UniProt Protein Name
Solute carrier family 12 member 1
UniProt Synonym Protein Names
Bumetanide-sensitive sodium-(potassium)-chloride cotransporter 2; Kidney-specific Na-K-Cl symporter
UniProt Gene Name
SLC12A1
UniProt Synonym Gene Names
NKCC2
UniProt Entry Name
S12A1_HUMAN
NCBI Protein Information
solute carrier family 12 member 1; NKCC2A variant A; Na-K-2Cl cotransporter; kidney-specific Na-K-Cl symporter; bumetanide-sensitive sodium-(potassium)-chloride cotransporter 2; solute carrier family 12 (sodium/potassium/chloride transporters), member 1

NCBI Summary for NKCC2

This gene encodes a kidney-specific sodium-potassium-chloride cotransporter that is expressed on the luminal membrane of renal epithelial cells of the thick ascending limb of Henle's loop and the macula densa. It plays a key role in concentrating urine and accounts for most of the NaCl resorption. It is sensitive to such diuretics as furosemide and bumetanide. Some Bartter-like syndromes result from defects in this gene. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional splice variants have been described but their biological validity in humans has not been experimentally proven.[provided by RefSeq, May 2010]
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UniProt Comments for NKCC2

NKCC2: Electrically silent transporter system. Mediates sodium and chloride reabsorption. Plays a vital role in the regulation of ionic balance and cell volume. Kidney specific. Activated by WNK3. Belongs to the SLC12A transporter family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Transporter; Transporter, SLC family; Membrane protein, integral; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 15q15-q21.1

Cellular Component: membrane; apical plasma membrane; plasma membrane; integral to membrane

Molecular Function: sodium:potassium:chloride symporter activity

Biological Process: transport; sodium ion transport; ion transport; chloride transport; excretion; kidney development; transmembrane transport; potassium ion transport; chemical homeostasis

Disease: Bartter Syndrome, Antenatal, Type 1
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Research Articles on NKCC2

1. overexpression of mammalian plasma-membrane Na+-K+-2Cl- co-transporter NKCC2 in yeast cells complements the phenotypes resulting from the deletion of the VHC1 gene.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with NKCC2 blocking peptide

 Reference Product  PubMed Publications
 AQP2 blocking peptide  >41 publications with NKCC2 and AQP2
 KCNJ1 blocking peptide  >38 publications with NKCC2 and KCNJ1
 CLCNKB blocking peptide  >16 publications with NKCC2 and CLCNKB
 STK39 blocking peptide  >15 publications with NKCC2 and STK39
 WNK4 blocking peptide  >10 publications with NKCC2 and WNK4
 BSND blocking peptide  >8 publications with NKCC2 and BSND
 WNK3 blocking peptide  >6 publications with NKCC2 and WNK3
 OXSR1 blocking peptide  >2 publications with NKCC2 and OXSR1

Pathways associated with NKCC2 blocking peptide

 Products by Pathway  Pathway Diagram
 Cation-coupled Chloride Cotransporters Pathway antibodies  Cation-coupled Chloride Cotransporters Pathway Diagram
 SLC-mediated Transmembrane Transport Pathway antibodies  SLC-mediated Transmembrane Transport Pathway Diagram
 Transmembrane Transport Of Small Molecules Pathway antibodies  Transmembrane Transport Of Small Molecules Pathway Diagram
 Transport Of Inorganic Cations/anions And Amino Acids/oligopeptides Pathway antibodies  Transport Of Inorganic Cations/anions And Amino Acids/oligopeptides Pathway Diagram

Diseases associated with NKCC2 blocking peptide

 Disease Name  Pubmed Publications
 Kidney Diseases Antibodies  >74 publications with NKCC2 and Kidney Diseases
 Hypertension Antibodies  >72 publications with NKCC2 and Hypertension
 Bartter Syndrome Antibodies  >39 publications with NKCC2 and Bartter Syndrome
 Disease Models, Animal Antibodies  >27 publications with NKCC2 and Disease Models, Animal
 Hypokalemia Antibodies  >24 publications with NKCC2 and Hypokalemia
 Polyuria Antibodies  >18 publications with NKCC2 and Polyuria
 Nervous System Diseases Antibodies  >13 publications with NKCC2 and Nervous System Diseases
 Renal Insufficiency Antibodies  >10 publications with NKCC2 and Renal Insufficiency
 Hypotension Antibodies  >7 publications with NKCC2 and Hypotension
 Heart Diseases Antibodies  >7 publications with NKCC2 and Heart Diseases

Organs/Tissues associated with NKCC2 blocking peptide

 Organ/Tissue Name  Pubmed Publications
 Kidney Antibodies  >226 publications with NKCC2 and Kidney
 Vascular Antibodies  >24 publications with NKCC2 and Vascular
 Brain Antibodies  >14 publications with NKCC2 and Brain
 Lung Antibodies  >8 publications with NKCC2 and Lung
 Muscle Antibodies  >7 publications with NKCC2 and Muscle
 Parathyroid Antibodies  >6 publications with NKCC2 and Parathyroid
 Intestine Antibodies  >5 publications with NKCC2 and Intestine
 Liver Antibodies  >5 publications with NKCC2 and Liver
 Bone Antibodies  >5 publications with NKCC2 and Bone
 Eye Antibodies  >4 publications with NKCC2 and Eye
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