NLGN2 Blocking Peptide – (19 amino acid peptide near the carboxy terminus of human NLGN2.)

NLGN2: Transmembrane scaffolding protein involved in cell-cell interactions via its interactions with neurexin family members. Mediates cell-cell interactions both in neurons and in other types of cells, such as Langerhans beta cells. Plays a role in synapse function and synaptic signal transmission, especially via gamma- aminobutyric acid receptors (GABA(A) receptors). Functions by recruiting and clustering synaptic proteins. Promotes clustering of postsynaptic GABRG2 and GPHN. Modulates signaling by inhibitory synapses, and thereby plays a role in controlling the ratio of signaling by excitatory and inhibitory synapses and information processing. Required for normal signal amplitude from inhibitory synapses, but is not essential for normal signal frequency. May promote the initial formation of synapses, but is not essential for this. In vitro, triggers the de novo formation of presynaptic structures. Mediates cell-cell interactions between Langerhans beta cells and modulates insulin secretion. Belongs to the type-B carboxylesterase/lipase family.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 17p13.1

Cellular Component: cell surface; integral to plasma membrane; plasma membrane; synapse

Molecular Function: cell adhesion molecule binding; neurexin binding; receptor activity

Biological Process: neurological control of breathing; neuron adhesion; positive regulation of insulin secretion; positive regulation of synaptic transmission, GABAergic; positive regulation of synaptic transmission, glutamatergic; positive regulation of synaptogenesis; regulation of synaptic transmission; synapse organization and biogenesis; synaptic vesicle endocytosis; synaptogenesis