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NPY2R Antibody Antigenic Blocking Peptide

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS544058

Antigenic Blocking Peptide Neuropeptide Y receptor Y2 AntibodyReceptor for neuropeptide Y and peptide YY More details

$315 / 0.25 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
NPY2R, Blocking Peptide
Full Product Name
NPY2R Antibody Antigenic Blocking Peptide
Product Gene Name
NPY2R blocking peptide
Product Synonym Names
Neuropeptide Y Receptor Type 2; NPY2R; NPYY2 Receptor; Y2 receptor antibody
Form/Format
Antigenic Blocking Peptide
Concentration
Quantity: 250 ug; Volume: 100 ul (lot specific)
Preparation and Storage
-20 degree C for long term storage
Antibody/Peptide Pairs
NPY2R peptide (MBS544058) is used for blocking the activity of NPY2R antibody (MBS540204)
Antibody/Peptide Pairs
NPY2R peptide (MBS544058) is used for blocking the activity of NPY2R antibody (MBS542245)
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Molecular Weight
42,731 Da
OMIM
162642
Immunogen
Synthetic Peptide
Expression
High levels in amygdala, corpus callosum, hippocampus and subthalamic nucleus. Also detectable in caudate nucleus, hypothalamus and substantia nigra.
Molecular Function
G-protein coupled receptor, Receptor, Transducer
Structure
Belongs to the G-protein coupled receptor 1 family
Subcellular Location
Cell membrane, Membrane
Applications Tested/Suitable for NPY2R blocking peptide
Immunocompetition, Immunodepletion
Application Notes for NPY2R blocking peptide
Western Blot: 1:500

Other Notes

Small volumes of NPY2R blocking peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for NPY2R purchase

MBS544058 is a blocking peptide targeting NPY2R. Also known as NPY2R Antibody Antigenic Blocking Peptide.

Additional Details

NCBI/Uniprot data below describe general gene information for NPY2R. It may not necessarily be applicable to this product.

NCBI GI #
29824918
NCBI GeneID
4887
NCBI Accession #
AAO92062.1
UniProt Primary Accession #
P49146
UniProt Secondary Accession #
Q13281; Q13457; Q4W5G7; Q6AZZ6; Q9UE67
UniProt Related Accession #
P49146
NCBI Official Full Name
neuropeptide Y receptor Y2
NCBI Official Synonym Full Names
neuropeptide Y receptor Y2
NCBI Official Symbol
NPY2R
NCBI Official Synonym Symbols
NPY2-R
UniProt Protein Name
Neuropeptide Y receptor type 2
UniProt Synonym Protein Names
NPY-Y2 receptor; Y2 receptor
Protein Family
Neuropeptide Y receptor
UniProt Gene Name
NPY2R
UniProt Synonym Gene Names
NPY2-R; Y2 receptor
UniProt Entry Name
NPY2R_HUMAN
NCBI Protein Information
neuropeptide Y receptor type 2

UniProt Comments for NPY2R

NPY2R: Receptor for neuropeptide Y and peptide YY. The rank order of affinity of this receptor for pancreatic polypeptides is PYY > NPY > PYY (3-36) > NPY (2-36) > [Ile-31, Gln-34] PP > [Leu- 31, Pro-34] NPY > PP, [Pro-34] PYY and NPY free acid. Belongs to the G-protein coupled receptor 1 family.

Protein type: GPCR, family 1; Receptor, GPCR; Membrane protein, multi-pass; Membrane protein, integral

Chromosomal Location of Human Ortholog: 4q31

Cellular Component: cytosol; integral to plasma membrane; nonmotile primary cilium; plasma membrane

Molecular Function: calcium channel regulator activity; neuropeptide Y receptor activity; peptide YY receptor activity; protein binding; receptor activity

Biological Process: behavioral fear response; cell surface receptor linked signal transduction; elevation of cytosolic calcium ion concentration; feeding behavior; G-protein signaling, adenylate cyclase inhibiting pathway; locomotory behavior; negative regulation of cAMP biosynthetic process; negative regulation of neurological process; negative regulation of secretion; negative regulation of synaptic transmission, glutamatergic; neuropeptide signaling pathway; nitric oxide mediated signal transduction; positive regulation of circadian sleep/wake cycle, non-REM sleep; positive regulation of dopamine secretion; positive regulation of peptide secretion; positive regulation of smooth muscle contraction; regulation of sensory perception of pain; secretion; synaptic transmission
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Research Articles on NPY2R

1. The C-terminal alpha-helix of Neuropeptide Y, which is formed in a membrane environment in the absence of the receptor, is unwound starting at T(32) to provide optimal contacts in a binding pocket within the transmembrane bundle of the NPY-Y2 receptor.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with NPY2R blocking peptide

 Products by Pathway  Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 G Alpha (i) Signalling Events Pathway antibodies  G Alpha (i) Signalling Events Pathway Diagram
 GPCR Downstream Signaling Pathway antibodies  GPCR Downstream Signaling Pathway Diagram
 GPCR Ligand Binding Pathway antibodies  GPCR Ligand Binding Pathway Diagram
 GPCRs, Class A Rhodopsin-like Pathway antibodies  GPCRs, Class A Rhodopsin-like Pathway Diagram
 Neuroactive Ligand-receptor Interaction Pathway antibodies  Neuroactive Ligand-receptor Interaction Pathway Diagram
 Neuroactive Ligand-receptor Interaction Pathway antibodies  Neuroactive Ligand-receptor Interaction Pathway Diagram
 Peptide GPCRs Pathway antibodies  Peptide GPCRs Pathway Diagram
 Peptide Ligand-binding Receptors Pathway antibodies  Peptide Ligand-binding Receptors Pathway Diagram
 Signal Transduction Pathway antibodies  Signal Transduction Pathway Diagram

Diseases associated with NPY2R blocking peptide

 Disease Name  Pubmed Publications
 Brain Diseases Antibodies  >3 publications with NPY2R and Brain Diseases
 Abnormalities, Multiple Antibodies  >2 publications with NPY2R and Abnormalities, Multiple
 Alcoholism Antibodies  >2 publications with NPY2R and Alcoholism
 Hypertension Antibodies  >2 publications with NPY2R and Hypertension
 Cognition Disorders Antibodies  >1 publications with NPY2R and Cognition Disorders
 Inflammation Antibodies  >1 publications with NPY2R and Inflammation
 Hypertrophy Antibodies  >1 publications with NPY2R and Hypertrophy
 Cardiomegaly Antibodies  >1 publications with NPY2R and Cardiomegaly
 Neurobehavioral Manifestations Antibodies  >1 publications with NPY2R and Neurobehavioral Manifestations
 Epilepsy Antibodies  >1 publications with NPY2R and Epilepsy

Organs/Tissues associated with NPY2R blocking peptide

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >15 publications with NPY2R and Brain
 Nerve Antibodies  >3 publications with NPY2R and Nerve
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