NR1I3 Blocking Peptide

Name: NR1I3 Blocking Peptide; MyBioSource
Brand: MyBioSource
SKU: MBS3228767
Price: 195 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS3228767

This is a synthetic peptide designed for use in combination with anti-NR1I3 antibody madeTarget Description: NR1I3 mediates the induction of transcription of cytochrome P450 (CYP) genes by phenobarbital (PB) and PB-type inducers. NR1I3 activation induces… More details

$195 / 0.1 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

NR1I3, Blocking Peptide

Full Product Name

NR1I3 Peptide

Product Gene Name

NR1I3 blocking peptide

Product Synonym Gene Name

CAR; MB67; Care2; ESTM32; AA209988; AI551208; CAR-beta

Form/Format

Lyophilized powder

Preparation and Storage

Add 100ul of sterile PBS. Final peptide concentration is 1 mg/ml in PBS. For longer periods of storage, store at -20 degree C. Avoid repeat freeze-thaw cycles.

Antibody/Peptide Pairs

NR1I3 peptide (MBS3228767) is used for blocking the activity of NR1I3 antibody (MBS3203799)

Molecular Weight

39kDa

Product Categories/Family for NR1I3 blocking peptide

Peptide

Applications Tested/Suitable for NR1I3 blocking peptide

Western Blot (WB)

Other Notes

Small volumes of NR1I3 blocking peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for NR1I3 purchase

MBS3228767 is a blocking peptide targeting NR1I3. Also known as NR1I3 Peptide.

Additional Details

NCBI/Uniprot data below describe general gene information for NR1I3. It may not necessarily be applicable to this product.

NCBI GI #

83921568

NCBI GeneID

12355

NCBI Accession #

NP_033933

UniProt Primary Accession #

O35627

UniProt Related Accession #

O35627

GenBank Nucleotide #

NM_009803

NCBI Official Full Name

nuclear receptor subfamily 1 group I member 3 isoform 1

NCBI Official Synonym Full Names

nuclear receptor subfamily 1, group I, member 3

NCBI Official Symbol

Nr1i3

NCBI Official Synonym Symbols

CAR; MB67; Care2; ESTM32; AA209988; AI551208; CAR-beta

UniProt Protein Name

Nuclear receptor subfamily 1 group I member 3

UniProt Synonym Protein Names

Constitutive androstane receptor; CAR; Orphan nuclear receptor MB67

Protein Family

Nuclear receptor subfamily

UniProt Gene Name

Nr1i3

UniProt Synonym Gene Names

Car; CAR

UniProt Entry Name

NR1I3_MOUSE

NCBI Protein Information

nuclear receptor subfamily 1 group I member 3

UniProt Comments for NR1I3

NR1I3: Binds and transactivates the retinoic acid response elements that control expression of the retinoic acid receptor beta 2 and alcohol dehydrogenase 3 genes. Transactivates both the phenobarbital responsive element module of the human CYP2B6 gene and the CYP3A4 xenobiotic response element. Interacts with ECT2. Heterodimer of NR1I3 and RXR. Interacts with PSMC4. Directly interacts with DNAJC7. The DNAJC7-NR1I3 complex may also include HSP90. By dexamethasone. Predominantly expressed in liver. Belongs to the nuclear hormone receptor family. NR1 subfamily. 7 isoforms of the human protein are produced by alternative splicing.

Protein type: Nuclear receptor; DNA-binding

Cellular Component: nucleoplasm; cytoskeleton; cytoplasm; cytosol; nucleus

Molecular Function: protein binding; DNA binding; zinc ion binding; sequence-specific DNA binding; metal ion binding; steroid hormone receptor activity; thyroid hormone receptor activity; transcription factor activity

Biological Process: transcription from RNA polymerase II promoter; transcription, DNA-dependent; regulation of transcription, DNA-dependent; steroid hormone mediated signaling; positive regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent

Research Articles on NR1I3

1. Study uncovered a novel function of CAR in mediating the kidney-liver cross-talk in acute kidney injury (AKI). Renal IR downregulated the expression and activity of CAR and decreased the expression of microsomal triglyceride transfer protein (MTTP), which resulted in a decreased very-low-density lipoprotein triglyceride (VLDL-TG) secretion and lipid accumulation and liver injury.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.