ODC1 Antibody (C-Term) Blocking Peptide

This gene encodes the rate-limiting enzyme of the polyamine biosynthesis pathway which catalyzes ornithine to putrescine. The activity level for the enzyme varies in response to growth-promoting stimuli and exhibits a high turnover rate in comparison to other mammalian proteins. Originally localized to both chromosomes 2 and 7, the gene encoding this enzyme has been determined to be located on 2p25, with a pseudogene located on 7q31-qter. Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Dec 2013]

ODC: the rate-limiting enzyme of the polyamine biosynthesis pathway which catalyzes ornithine to putrescine. The activity level for the enzyme varies in response to growth-promoting stimuli and exhibits a high turnover rate in comparison to other mammalian proteins. Originally localized to both chromosomes 2 and 7, the gene encoding this enzyme has been determined to be located on 2p25, with a pseudogene located on 7q31-qter. [provided by RefSeq, Jul 2008]

Protein type: Other Amino Acids Metabolism - glutathione; EC 4.1.1.17; Cell cycle regulation; Lyase; Amino Acid Metabolism - arginine and proline

Chromosomal Location of Human Ortholog: 2p25

Cellular Component: cytoplasm; cytosol

Molecular Function: ornithine decarboxylase activity; protein binding; protein homodimerization activity

Biological Process: polyamine metabolic process; putrescine biosynthetic process from ornithine; regulation of amino acid metabolic process; regulation of protein catabolic process; response to virus

Disease: Colorectal Cancer