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PDCD4 Antibody (Center) Blocking Peptide

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS9220366

Inhibits translation initiation and cap-dependent translation. May excert its function by hindering the interaction between EIF4A1 and EIF4G. Inhibits the helicase activity of EIF4A. Modulates the activation of JUN kinase. Down-regulates the expression of… More details

$455 / 0.5 mg +1 FREE 8GB USB
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
PDCD4, Blocking Peptide
Full Product Name
PDCD4 Antibody (Center) Blocking peptide
Product Gene Name
PDCD4 blocking peptide
Product Synonym Gene Name
H731
Product Synonym Names
Programmed cell death protein 4; Neoplastic transformation inhibitor protein; Nuclear antigen H731-like; Protein 197/15a; PDCD4; H731
Form/Format
Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
Specificity
The synthetic peptide sequence used to generate the antibody was selected from the Center region of PDCD4. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Preparation and Storage
Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.
Antibody/Peptide Pairs
PDCD4 peptide (MBS9220366) is used for blocking the activity of PDCD4 antibody (MBS9214815)
Molecular Weight
50,576 Da
OMIM
608610
Cellular Location
Nucleus. Cytoplasm. Note: Shuttles between the nucleus and cytoplasm. Predominantly nuclear under normal growth conditions, and when phosphorylated at Ser-457. Exported from the nucleus in the absence of serum
Tissue Location
Up-regulated in proliferative cells. Highly expressed in epithelial cells of the mammary gland. Reduced expression in lung cancer and colon carcinoma

Other Notes

Small volumes of PDCD4 blocking peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for PDCD4 purchase

MBS9220366 is a blocking peptide targeting PDCD4. Also known as PDCD4 Antibody (Center) Blocking peptide.

Additional Details

NCBI/Uniprot data below describe general gene information for PDCD4. It may not necessarily be applicable to this product.

NCBI GI #
317373317
NCBI GeneID
27250
NCBI Accession #
Q53EL6.2
UniProt Primary Accession #
Q53EL6
UniProt Secondary Accession #
O15501; Q5VZS6; Q6PJI5; Q8TAR5; Q99834; B2RCV4; B5ME91
UniProt Related Accession #
Q53EL6
NCBI Official Full Name
Programmed cell death protein 4
NCBI Official Synonym Full Names
programmed cell death 4 (neoplastic transformation inhibitor)
NCBI Official Symbol
PDCD4
NCBI Official Synonym Symbols
H731
UniProt Protein Name
Programmed cell death protein 4
UniProt Synonym Protein Names
Neoplastic transformation inhibitor protein; Nuclear antigen H731-like; Protein 197/15a
Protein Family
Programmed cell death protein
UniProt Gene Name
PDCD4
UniProt Synonym Gene Names
H731
UniProt Entry Name
PDCD4_HUMAN
NCBI Protein Information
programmed cell death protein 4

NCBI Summary for PDCD4

This gene is a tumor suppressor and encodes a protein that binds to the eukaryotic translation initiation factor 4A1 and inhibits its function by preventing RNA binding. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2010]

UniProt Comments for PDCD4

PDCD4: protein localized to the nucleus in proliferating cells that seems to possess a tumor suppressor activity. Directly interacts with the RNA helicase eIF4A and inhibits protein synthesis by interfering with the assembly of the cap-dependent translation initiation complex. Suppresses carbonic anhydrase type II protein expression in carcinoid cell lines. Since tumor cells require a high bicarbonate flux for their growth, carbonic anhydrase suppression results in growth inhibition. Expression of this gene is modulated by cytokines in natural killer and T cells. The gene product is thought to play a role in apoptosis but the specific role has not yet been determined. Two differentially spliced isoforms have been identified.

Protein type: Apoptosis; Tumor suppressor

Chromosomal Location of Human Ortholog: 10q24

Cellular Component: cytoplasm; cytosol; nucleoplasm; nucleus

Molecular Function: protein binding

Biological Process: cell aging; negative regulation of JNK activity; negative regulation of transcription, DNA-dependent
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Research Articles on PDCD4

1. Results indicated that PDCD4 may be a novel candidate of tumor suppressor gene in hepatocellular carcinoma and that promoter hypermethylation is an important mechanism for its downregulation and a good predictor of survival.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with PDCD4 blocking peptide

 Reference Product  PubMed Publications
 MYB blocking peptide  >9 publications with PDCD4 and MYB
 RPS13 blocking peptide  >1 publications with PDCD4 and RPS13
 EIF4G1 blocking peptide  >1 publications with PDCD4 and EIF4G1
 RPS6KA1 blocking peptide  >1 publications with PDCD4 and RPS6KA1
 BTRC blocking peptide  >1 publications with PDCD4 and BTRC
 EIF4A1 blocking peptide  >1 publications with PDCD4 and EIF4A1

Pathways associated with PDCD4 blocking peptide

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 Proteoglycans In Cancer Pathway antibodies  Proteoglycans In Cancer Pathway Diagram
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 MTOR Signaling Pathway antibodies  MTOR Signaling Pathway Diagram

Diseases associated with PDCD4 blocking peptide

 Disease Name  Pubmed Publications
 Adenocarcinoma Antibodies  >75 publications with PDCD4 and Adenocarcinoma
 Neoplasm Metastasis Antibodies  >56 publications with PDCD4 and Neoplasm Metastasis
 Cell Transformation, Neoplastic Antibodies  >46 publications with PDCD4 and Cell Transformation, Neoplastic
 Neoplasm Invasiveness Antibodies  >42 publications with PDCD4 and Neoplasm Invasiveness
 Inflammation Antibodies  >40 publications with PDCD4 and Inflammation
 Breast Neoplasms Antibodies  >35 publications with PDCD4 and Breast Neoplasms
 Liver Diseases Antibodies  >33 publications with PDCD4 and Liver Diseases
 Lung Neoplasms Antibodies  >32 publications with PDCD4 and Lung Neoplasms
 Lung Diseases Antibodies  >30 publications with PDCD4 and Lung Diseases
 Liver Neoplasms Antibodies  >28 publications with PDCD4 and Liver Neoplasms

Organs/Tissues associated with PDCD4 blocking peptide

 Organ/Tissue Name  Pubmed Publications
 Lung Antibodies  >50 publications with PDCD4 and Lung
 Liver Antibodies  >46 publications with PDCD4 and Liver
 Blood Antibodies  >44 publications with PDCD4 and Blood
 Muscle Antibodies  >34 publications with PDCD4 and Muscle
 Brain Antibodies  >26 publications with PDCD4 and Brain
 Heart Antibodies  >24 publications with PDCD4 and Heart
 Lymph Antibodies  >22 publications with PDCD4 and Lymph
 Lymph Node Antibodies  >22 publications with PDCD4 and Lymph Node
 Skin Antibodies  >22 publications with PDCD4 and Skin
 Bone Antibodies  >19 publications with PDCD4 and Bone
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