• Call +1.858.633.0165 or Fax +1.858.633.0166 or Contact Us

PFKFB4 Antibody (Center) Blocking Peptide

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS9227594

MBS9227594 is a blocking peptide targeting PFKFB4. Also known as PFKFB4 Antibody (Center) Blocking Peptide. Synthesis and degradation of fructose 2,6-bisphosphate. More details

$455 / 0.5 mg +1 FREE 8GB USB
Product Documentation
PDF
Sample Manual Insert View PDF
PDF
Testing Data View PDF
PDF
Certificate of Analysis (COA) View PDF
PDF
QC Report View PDF
PDF
Material Safety Data Sheet View PDF
PDF
Technical Datasheet View PDF
PDF
Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
PFKFB4, Blocking Peptide
Full Product Name
PFKFB4 Antibody (Center) Blocking Peptide
Product Gene Name
Product Synonym Names
6-phosphofructo-2-kinase/fructose-2;6-bisphosphatase 4; 6PF-2-K/Fru-2;6-P2ase 4; PFK/FBPase 4; 6PF-2-K/Fru-2;6-P2ase testis-type isozyme; 6-phosphofructo-2-kinase; Fructose-2;6-bisphosphatase; PFKFB4
Form/Format
The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.
Specificity
The synthetic peptide sequence used to generate the antibody was selected from the Center region of human PFKFB4. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Preparation and Storage
Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.
Antibody/Peptide Pairs
PFKFB4 peptide (MBS9227594) is used for blocking the activity of PFKFB4 antibody (MBS9201289)
Molecular Weight
50,203 Da
OMIM
605320

Other Notes

Small volumes of PFKFB4 blocking peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for PFKFB4. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4
NCBI Official Synonym Full Names
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4
NCBI Official Symbol
PFKFB4
UniProt Protein Name
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4
UniProt Synonym Protein Names
6PF-2-K/Fru-2,6-P2ase testis-type isozymeIncluding the following 2 domains:6-phosphofructo-2-kinase (EC:2.7.1.105)Fructose-2,6-bisphosphatase (EC:3.1.3.46)
UniProt Gene Name
PFKFB4
UniProt Synonym Gene Names
6PF-2-K/Fru-2,6-P2ase 4; PFK/FBPase 4
UniProt Entry Name
F264_HUMAN
NCBI Protein Information
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4

NCBI Summary for PFKFB4

The protein encoded by this gene is one of four bifunctional kinase/phosphatases that regulate the concentration of the glycolytic byproduct fructose-2,6-bisphosphate (F2,6BP). The encoded protein is highly expressed in cancer cells and is induced by hypoxia. This protein is essential to the survival of cancer cells under conditions of hypoxia, because it increases the amount of F2,6BP and ATP at a time when the cell cannot produce much of them. This finding suggests that this protein may be a good target for disruption in cancer cells, hopefully imperiling their survival. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2015]
Show more

UniProt Comments for PFKFB4

PFKFB4: Synthesis and degradation of fructose 2,6-bisphosphate.

Protein type: EC 3.1.3.46; Motility/polarity/chemotaxis; EC 2.7.1.105; Phosphatase (non-protein); Carbohydrate Metabolism - fructose and mannose; Kinase, other

Chromosomal Location of Human Ortholog: 3p22-p21

Cellular Component: cytosol

Molecular Function: 6-phosphofructo-2-kinase activity
Show more

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Request a Quote

Please fill out the form below and our representative will get back to you shortly.

MBS000000
Contact Us

Please fill out the form below and our representative will get back to you shortly.

MBS000000