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Pgp9.5 Blocking Peptide – The purity is >90%,tested by HPLC and MS. Purity

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS9614732

Blocking peptides are peptides that bind specifically to the target antibody and block antibody binding. These peptide usually contains the epitope recognized by the antibody. Antibodies bound to the blocking peptide no longer bind to the epitope on the… More details

$460 / 1 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
PGP9.5, Blocking Peptide
Full Product Name
PGP9.5 Blocking Peptide
Product Gene Name
PGP9.5 blocking peptide
Product Synonym Gene Name
UCHL1
Product Synonym Names
Epididymis luminal protein 117; Epididymis secretory protein Li 53; HEL 117; HEL S 53; NDGOA; Neuron cytoplasmic protein 9.5; OTTHUMP00000218137; OTTHUMP00000218139; OTTHUMP00000218140; OTTHUMP00000218141; Park 5; PARK5; PGP 9.5; PGP9.5; PGP95; Protein gene product 9.5; Ubiquitin C terminal esterase L1; Ubiquitin C terminal hydrolase; Ubiquitin C terminal hydrolase L1; Ubiquitin carboxyl terminal esterase L1; Ubiquitin carboxyl terminal hydrolase isozyme L1; Ubiquitin carboxyl-terminal hydrolase isozyme L1; Ubiquitin thioesterase L1; Ubiquitin thiolesterase; Ubiquitin thiolesterase L1; UCH-L1; UCHL1; UCHL1_HUMAN
Form/Format
Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 10 mg/ml.
Purity/Purification
The purity is >90%,tested by HPLC and MS.
Preparation and Storage
Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.
Antibody/Peptide Pairs
PGP9.5 peptide (MBS9614732) is used for blocking the activity of PGP9.5 antibody (MBS9600180)
Molecular Weight
24,824 Da
Chromosome Location
Chromosome: 4; NC_000004.11 (41258898..41270446). Location: 4p14
OMIM
191342
Supply Chain Verification
Manufactured in a lab with traceable raw materials manufactured on site. Coordinated product portfolio of antibodies, pairs, conjugates, recombinant proteins, and immunoassay materials available, please inquire.
Notes
For phospho antibody, we provide phospho peptide (0.5mg) and non-phospho peptide (0.5mg)
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Applications Tested/Suitable for PGP9.5 blocking peptide
Blocking/Control

Other Notes

Small volumes of PGP9.5 blocking peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for PGP9.5 purchase

MBS9614732 is a blocking peptide targeting PGP9.5.

Additional Details

NCBI/Uniprot data below describe general gene information for PGP9.5. It may not necessarily be applicable to this product.

NCBI GI #
21361091
NCBI GeneID
7345
NCBI Accession #
NP_004172.2
UniProt Primary Accession #
P09936
UniProt Secondary Accession #
Q4W5K6; Q71UM0
UniProt Related Accession #
P09936
GenBank Nucleotide #
NM_004181.4
NCBI Official Full Name
ubiquitin carboxyl-terminal hydrolase isozyme L1
NCBI Official Synonym Full Names
ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
NCBI Official Symbol
UCHL1
NCBI Official Synonym Symbols
PARK5; PGP95; PGP9.5; Uch-L1; PGP 9.5
UniProt Protein Name
Ubiquitin carboxyl-terminal hydrolase isozyme L1
UniProt Synonym Protein Names
Neuron cytoplasmic protein 9.5; PGP 9.5; PGP9.5; Ubiquitin thioesterase L1
Protein Family
Ubiquitin carboxyl-terminal hydrolase
UniProt Gene Name
UCHL1
UniProt Synonym Gene Names
UCH-L1; PGP9.5
UniProt Entry Name
UCHL1_HUMAN
NCBI Protein Information
ubiquitin carboxyl-terminal hydrolase isozyme L1; ubiquitin thioesterase L1; neuron cytoplasmic protein 9.5; ubiquitin C-terminal hydrolase

NCBI Summary for PGP9.5

The protein encoded by this gene belongs to the peptidase C12 family. This enzyme is a thiol protease that hydrolyzes a peptide bond at the C-terminal glycine of ubiquitin. This gene is specifically expressed in the neurons and in cells of the diffuse neuroendocrine system. Mutations in this gene may be associated with Parkinson disease.[provided by RefSeq, Sep 2009]
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UniProt Comments for PGP9.5

UCHL1: Ubiquitin-protein hydrolase involved both in the processing of ubiquitin precursors and of ubiquitinated proteins. This enzyme is a thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminal glycine of ubiquitin. Also binds to free monoubiquitin and may prevent its degradation in lysosomes. The homodimer may have ATP-independent ubiquitin ligase activity. Monomer. Homodimer. Interacts with SNCA. Interacts with COPS5. Found in neuronal cell bodies and processes throughout the neocortex. Expressed in neurons and cells of the diffuse neuroendocrine system and their tumors. Weakly expressed in ovary. Down-regulated in brains from Parkinson disease and Alzheimer disease patients. Belongs to the peptidase C12 family.

Protein type: Cell development/differentiation; EC 3.4.19.12; Ligase; Protease; Ubiquitin conjugating system

Chromosomal Location of Human Ortholog: 4p14

Cellular Component: nucleoplasm; endoplasmic reticulum membrane; cell soma; axon; cytoplasm; plasma membrane; cytosol

Molecular Function: protein binding; omega peptidase activity; ubiquitin binding; cysteine-type endopeptidase activity; ubiquitin-specific protease activity; alpha-2A adrenergic receptor binding; ligase activity

Biological Process: proteasomal ubiquitin-dependent protein catabolic process; cell proliferation; negative regulation of MAP kinase activity; protein deubiquitination; axon transport of mitochondrion; axon target recognition; eating behavior; neuromuscular process; sensory perception of pain; muscle fiber development; adult walking behavior

Disease: Neurodegeneration With Optic Atrophy, Childhood-onset; Parkinson Disease 5, Autosomal Dominant
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Research Articles on PGP9.5

1. Results showed that NT, NPY, and PGP 9.5 neurofibers are almost equally present in pseudocapsule of uterine fibroids as in normal myometrium of a no pregnant uterus. As all of these neuropeptides are present in the uterine muscle and can affect muscle contractility, uterine peristalsis and muscular healing.
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with PGP9.5 blocking peptide

 Reference Product  PubMed Publications
 HSP90AA1 blocking peptide  >2 publications with PGP9.5 and HSP90AA1
 CDKN1B blocking peptide  >2 publications with PGP9.5 and CDKN1B
 NEDD8 blocking peptide  >1 publications with PGP9.5 and NEDD8
 LAMP2 blocking peptide  >1 publications with PGP9.5 and LAMP2
 HSPA8 blocking peptide  >1 publications with PGP9.5 and HSPA8

Pathways associated with PGP9.5 blocking peptide

 Products by Pathway  Pathway Diagram
 Alpha-synuclein Signaling Pathway antibodies  Alpha-synuclein Signaling Pathway Diagram
 Parkinson's Disease Pathway antibodies  Parkinson's Disease Pathway Diagram
 Parkinsons Disease Pathway antibodies  Parkinsons Disease Pathway Diagram
 Proteasome Degradation Pathway antibodies  Proteasome Degradation Pathway Diagram

Diseases associated with PGP9.5 blocking peptide

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >263 publications with PGP9.5 and Neoplasms
 Nervous System Diseases Antibodies  >192 publications with PGP9.5 and Nervous System Diseases
 Brain Diseases Antibodies  >142 publications with PGP9.5 and Brain Diseases
 Inflammation Antibodies  >46 publications with PGP9.5 and Inflammation
 Adenocarcinoma Antibodies  >29 publications with PGP9.5 and Adenocarcinoma
 Peripheral Nervous System Diseases Antibodies  >29 publications with PGP9.5 and Peripheral Nervous System Diseases
 Cardiovascular Diseases Antibodies  >27 publications with PGP9.5 and Cardiovascular Diseases
 Disease Models, Animal Antibodies  >27 publications with PGP9.5 and Disease Models, Animal
 Necrosis Antibodies  >19 publications with PGP9.5 and Necrosis
 Nerve Degeneration Antibodies  >18 publications with PGP9.5 and Nerve Degeneration

Organs/Tissues associated with PGP9.5 blocking peptide

 Organ/Tissue Name  Pubmed Publications
 Nerve Antibodies  >173 publications with PGP9.5 and Nerve
 Brain Antibodies  >106 publications with PGP9.5 and Brain
 Skin Antibodies  >85 publications with PGP9.5 and Skin
 Bone Antibodies  >59 publications with PGP9.5 and Bone
 Lymph Antibodies  >55 publications with PGP9.5 and Lymph
 Lung Antibodies  >36 publications with PGP9.5 and Lung
 Mouth Antibodies  >27 publications with PGP9.5 and Mouth
 Testis Antibodies  >20 publications with PGP9.5 and Testis
 Uterus Antibodies  >19 publications with PGP9.5 and Uterus
 Embryonic Tissue Antibodies  >18 publications with PGP9.5 and Embryonic Tissue
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