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Phospho-MERTK Blocking Peptide – (CCKKIYPSGDYPYPRQG)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS544294

Antigenic Blocking Peptide Phosphorylated Tyrosine-protein kinase MerReceptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to several ligands including LGALS3, TUB, TULP1 or GAS6. Regulates many… More details

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Product Overview

Online Datasheet in PDF
Product Name
Phospho-MERTK, Blocking Peptide
Full Product Name
Phospho-MERTK Peptide
Product Gene Name
MERTK blocking peptide
Product Synonym Names
c MER antibody;c mer proto oncogene tyrosine kinase antibody;Eyk antibody;MER antibody;MERPEN antibody;Mertk antibody;MERTK c-mer proto-oncogene tyrosine kinase antibody;MGC133349 antibody;nmf12 antibody;Nyk antibody;Proto oncogene tyrosine protein kinase MER antibody;Receptor tyrosine kinase MerTK antibody;RP38 antibody;STK kinase antibody;Tyrosine-protein kinase Mer antibody
Form/Format
Synthetic Peptide
Preparation and Storage
-20 degree C for long term storage
Antibody/Peptide Pairs
Phospho-MERTK peptide (MBS544294) is used for blocking the activity of Phospho-MERTK antibody (MBS540099)
Antibody/Peptide Pairs
Phospho-MERTK peptide (MBS544294) is used for blocking the activity of Phospho-MERTK antibody (MBS543988)
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Sequence Positions
CCKKIYPSGDYPYPRQG
Immunogen Description
Synthetic peptide corresponding to amino acids 746-757 of Human MERTK.
Molecular Function
Kinase, Receptor, Transferase, Tyrosine-protein kinase
Structure
Interacts (upon activation) with TNK2; stimulates TNK2 autophosphorylation. Interacts (via N-terminus) with extracellular ligands LGALS3, TUB, TULP1 and GAS6. Interacts with VAV1 in a phosphotyrosine-independent manner.
Subcellular Location
Membrane; Single-pass type I membrane protein
Applications Tested/Suitable for MERTK blocking peptide
Immunodepletion, Immunocompetition

Other Notes

Small volumes of MERTK blocking peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for MERTK purchase

MBS544294 is a blocking peptide targeting MERTK. Also known as Phospho-MERTK Peptide.

Additional Details

NCBI/Uniprot data below describe general gene information for MERTK. It may not necessarily be applicable to this product.

NCBI GI #
12738847
NCBI GeneID
65037
NCBI Accession #
NP_075232.1
UniProt Primary Accession #
P57097
UniProt Related Accession #
P57097
GenBank Nucleotide #
NM_022943.1
NCBI Official Full Name
tyrosine-protein kinase Mer
NCBI Official Synonym Full Names
MER proto-oncogene, tyrosine kinase
NCBI Official Symbol
Mertk
NCBI Official Synonym Symbols
rdy
UniProt Protein Name
Tyrosine-protein kinase Mer
UniProt Synonym Protein Names
Proto-oncogene c-Mer; Receptor tyrosine kinase MerTK
Protein Family
Tyrosine-protein kinase
UniProt Gene Name
Mertk
UniProt Synonym Gene Names
Mer
UniProt Entry Name
MERTK_RAT
NCBI Protein Information
tyrosine-protein kinase Mer

NCBI Summary for MERTK

receptor tyrosine kinase; involved in the phagocytoses of the shed outer segments by retinal pigment epithelial (RPE) cells [RGD, Feb 2006]

UniProt Comments for MERTK

Mer: a proto-oncogene receptor tyrosine-protein kinase of the Axl family. Binds several ligands including LGALS3, Tubby, TULP1 or GAS6. Regulates many physiological processes including cell survival, migration, differentiation, and phagocytosis of apoptotic cells (efferocytosis). Functions in the retinal pigment epithelium (RPE) as a regulator of rod outer segments fragments phagocytosis. Plays also an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response by activating STAT1, which selectively induces production of suppressors of cytokine signaling SOCS1 and SOCS3

Protein type: Kinase, protein; EC 2.7.10.1; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor); TK group; Axl family

Cellular Component: cytoplasm; extracellular space; integral to membrane; photoreceptor outer segment

Molecular Function: ATP binding; transmembrane receptor protein tyrosine kinase activity

Biological Process: apoptotic cell clearance; natural killer cell differentiation; negative regulation of lymphocyte activation; peptidyl-tyrosine phosphorylation; phagocytosis; platelet activation; positive regulation of phagocytosis; protein amino acid phosphorylation; protein kinase B signaling cascade; retina development in camera-type eye; secretion by cell; spermatogenesis; vagina development
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Research Articles on MERTK

1. A novel role of MERTK signaling in membrane trafficking in the Retinal Pigment Eepithelium that is likely to subserve mechanisms of phagosome formation.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with MERTK blocking peptide

 Reference Product  PubMed Publications
 Gas6 blocking peptide  >100 publications with MERTK and Gas6
 Rpe65 blocking peptide  >19 publications with MERTK and Rpe65
 Abca4 blocking peptide  >10 publications with MERTK and Abca4
 Tulp1 blocking peptide  >8 publications with MERTK and Tulp1
 Pik3r1 blocking peptide  >1 publications with MERTK and Pik3r1

Diseases associated with MERTK blocking peptide

 Disease Name  Pubmed Publications
 Inflammation Antibodies  >74 publications with MERTK and Inflammation
 Disease Models, Animal Antibodies  >56 publications with MERTK and Disease Models, Animal
 Retinitis Pigmentosa Antibodies  >47 publications with MERTK and Retinitis Pigmentosa
 Nervous System Diseases Antibodies  >31 publications with MERTK and Nervous System Diseases
 Necrosis Antibodies  >30 publications with MERTK and Necrosis
 Lung Diseases Antibodies  >17 publications with MERTK and Lung Diseases
 Liver Diseases Antibodies  >11 publications with MERTK and Liver Diseases
 Carcinoma Antibodies  >11 publications with MERTK and Carcinoma
 Fibrosis Antibodies  >10 publications with MERTK and Fibrosis
 Nerve Degeneration Antibodies  >10 publications with MERTK and Nerve Degeneration

Organs/Tissues associated with MERTK blocking peptide

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >35 publications with MERTK and Brain
 Lung Antibodies  >23 publications with MERTK and Lung
 Spleen Antibodies  >17 publications with MERTK and Spleen
 Kidney Antibodies  >9 publications with MERTK and Kidney
 Colon Antibodies  >5 publications with MERTK and Colon
 Dorsal Root Ganglion Antibodies  >1 publications with MERTK and Dorsal Root Ganglion
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