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PNPLA8 Antibody (N-Term) Blocking Peptide

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS9225335

Calcium-independent phospholipase A2, which catalyzes the hydrolysis of the sn-2 position of glycerophospholipids, PtdSer and to a lower extent PtdCho. Cleaves membrane phospholipids. More details

$455 / 0.5 mg +1 FREE 8GB USB
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Product Overview

Online Datasheet in PDF
Product Name
PNPLA8, Blocking Peptide
Full Product Name
PNPLA8 Antibody (N-term) Blocking Peptide
Product Gene Name
PNPLA8 blocking peptide
Product Synonym Gene Name
IPLA22; IPLA2G
Product Synonym Names
Calcium-independent phospholipase A2-gamma; Intracellular membrane-associated calcium-independent phospholipase A2 gamma; iPLA2-gamma; PNPLA-gamma; Patatin-like phospholipase domain-containing protein 8; iPLA2-2; PNPLA8; IPLA22; IPLA2G
Form/Format
Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
Preparation and Storage
Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.
Antibody/Peptide Pairs
PNPLA8 peptide (MBS9225335) is used for blocking the activity of PNPLA8 antibody (MBS9204471)
Molecular Weight
77,031 Da
OMIM
251950
Cellular Location
Endoplasmic reticulum membrane; Single-pass membrane protein. Golgi apparatus membrane; Single-pass membrane protein. Cytoplasm, perinuclear region
Tissue Location
Expressed in parenchymal tissues including heart, skeletal muscle, placenta, brain, liver and pancreas. Also expressed in bronchial epithelial cells and kidney. Highest expression is observed in skeletal muscle and heart

Other Notes

Small volumes of PNPLA8 blocking peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for PNPLA8 purchase

MBS9225335 is a blocking peptide targeting PNPLA8. Also known as PNPLA8 Antibody (N-term) Blocking Peptide.

Additional Details

NCBI/Uniprot data below describe general gene information for PNPLA8. It may not necessarily be applicable to this product.

NCBI GI #
74734299
NCBI GeneID
50640
NCBI Accession #
Q9NP80.1
UniProt Primary Accession #
Q9NP80
UniProt Secondary Accession #
O95035; Q8N3I3; Q9H7T5; Q9NR17; Q9NUN2; Q9NZ79; A4D0S1; C9JZI4
UniProt Related Accession #
Q9NP80
NCBI Official Full Name
Calcium-independent phospholipase A2-gamma
NCBI Official Synonym Full Names
patatin like phospholipase domain containing 8
NCBI Official Symbol
PNPLA8
NCBI Official Synonym Symbols
MMLA; IPLA2G; IPLA2-2; iPLA2gamma; PNPLA-gamma
UniProt Protein Name
Calcium-independent phospholipase A2-gamma
UniProt Synonym Protein Names
Intracellular membrane-associated calcium-independent phospholipase A2 gamma; iPLA2-gamma; PNPLA-gamma; Patatin-like phospholipase domain-containing protein 8; iPLA2-2
Protein Family
Calcium-independent phospholipase
UniProt Gene Name
PNPLA8
UniProt Synonym Gene Names
IPLA22; IPLA2G; iPLA2-gamma
UniProt Entry Name
PLPL8_HUMAN
NCBI Protein Information
calcium-independent phospholipase A2-gamma

NCBI Summary for PNPLA8

This gene encodes a member of the patatin-like phospholipase domain containing protein family. Members of this family are phospholipases which catalyze the cleavage of fatty acids from membrane phospholipids. The product of this gene is a calcium-independent phospholipase. Mutations in this gene have been associated with mitochondrial myopathy with lactic acidosis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2015]
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UniProt Comments for PNPLA8

PNPLA8: Calcium-independent phospholipase A2, which catalyzes the hydrolysis of the sn-2 position of glycerophospholipids, PtdSer and to a lower extent PtdCho. Cleaves membrane phospholipids. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; EC 3.1.1.5; Phospholipase; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 7q31

Cellular Component: endoplasmic reticulum membrane; intracellular; membrane; peroxisomal membrane; peroxisome

Molecular Function: calcium-independent phospholipase A2 activity; phospholipase A2 activity

Biological Process: arachidonic acid metabolic process; arachidonic acid secretion; cell death; fatty acid metabolic process; linoleic acid metabolic process; phosphatidylethanolamine catabolic process; prostaglandin biosynthetic process

Disease: Mitochondrial Myopathy With Lactic Acidosis
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Research Articles on PNPLA8

1. iPLA2gamma plays an important role in in vivo Thromboxane A2 production accompanied by thrombus formation.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with PNPLA8 blocking peptide

 Products by Pathway  Pathway Diagram
 Acyl Chain Remodelling Of PC Pathway antibodies  Acyl Chain Remodelling Of PC Pathway Diagram
 Acyl Chain Remodelling Of PE Pathway antibodies  Acyl Chain Remodelling Of PE Pathway Diagram
 Eicosanoid Synthesis Pathway antibodies  Eicosanoid Synthesis Pathway Diagram
 Glycerophospholipid Biosynthesis Pathway antibodies  Glycerophospholipid Biosynthesis Pathway Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Lipids And Lipoproteins Pathway antibodies  Metabolism Of Lipids And Lipoproteins Pathway Diagram
 Phospholipid Metabolism Pathway antibodies  Phospholipid Metabolism Pathway Diagram
 Phospholipases Pathway antibodies  Phospholipases Pathway Diagram

Diseases associated with PNPLA8 blocking peptide

 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >2 publications with PNPLA8 and Nervous System Diseases
 Cardiovascular Diseases Antibodies  >1 publications with PNPLA8 and Cardiovascular Diseases
 Seizures Antibodies  >1 publications with PNPLA8 and Seizures
 Weight Loss Antibodies  >1 publications with PNPLA8 and Weight Loss
 Inflammation Antibodies  >1 publications with PNPLA8 and Inflammation

Organs/Tissues associated with PNPLA8 blocking peptide

 Organ/Tissue Name  Pubmed Publications
 Bone Antibodies  >1 publications with PNPLA8 and Bone
 Muscle Antibodies  >1 publications with PNPLA8 and Muscle
 Heart Antibodies  >1 publications with PNPLA8 and Heart
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