POLD1 Antibody (Center) Blocking Peptide

This gene encodes the 125-kDa catalytic subunit of DNA polymerase delta. DNA polymerase delta possesses both polymerase and 3' to 5' exonuclease activity and plays a critical role in DNA replication and repair. Alternatively spliced transcript variants have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 6. [provided by RefSeq, Mar 2012]

POLD1: Possesses two enzymatic activities: DNA synthesis (polymerase) and an exonucleolytic activity that degrades single stranded DNA in the 3'- to 5'-direction. Required with its accessory proteins (proliferating cell nuclear antigen (PCNA) and replication factor C (RFC) or activator 1) for leading strand synthesis. Also involved in completing Okazaki fragments initiated by the DNA polymerase alpha/primase complex. Belongs to the DNA polymerase type-B family.

Protein type: Transferase; EC 2.7.7.7; Nucleotide Metabolism - pyrimidine; Hydrolase; DNA replication; DNA repair, damage; Nucleotide Metabolism - purine

Chromosomal Location of Human Ortholog: 19q13.3

Cellular Component: cytoplasm; delta DNA polymerase complex; membrane; nuclear chromosome, telomeric region; nucleoplasm; nucleotide-excision repair complex; nucleus

Molecular Function: 3'-5'-exodeoxyribonuclease activity; chromatin binding; damaged DNA binding; DNA binding; DNA-directed DNA polymerase activity; protein binding

Biological Process: base-excision repair, gap-filling; bypass DNA synthesis; DNA damage response, detection of DNA damage; DNA repair; DNA replication; DNA replication proofreading; DNA strand elongation during DNA replication; DNA synthesis during DNA repair; fatty acid homeostasis; mismatch repair; nucleotide-excision repair, DNA gap filling; nucleotide-excision repair, DNA incision; nucleotide-excision repair, DNA incision, 5'-to lesion; response to UV; telomere maintenance; telomere maintenance via recombination; transcription-coupled nucleotide-excision repair

Disease: Colorectal Cancer, Susceptibility To, 10; Mandibular Hypoplasia, Deafness, Progeroid Features, And Lipodystrophy Syndrome