POLD2 Blocking Peptide (Center) Blocking Peptide

This gene encodes the 50-kDa catalytic subunit of DNA polymerase delta. DNA polymerase delta possesses both polymerase and 3' to 5' exonuclease activity and plays a critical role in DNA replication and repair. The encoded protein is required for the stimulation of DNA polymerase delta activity by the processivity cofactor proliferating cell nuclear antigen (PCNA). Expression of this gene may be a marker for ovarian carcinomas. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 5. [provided by RefSeq, Mar 2012]

POLD2: The function of the small subunit is not yet clear. Belongs to the DNA polymerase delta/II small subunit family.

Protein type: DNA repair, damage; Nucleotide Metabolism - purine; Transferase; EC 2.7.7.7; Nucleotide Metabolism - pyrimidine; DNA replication

Chromosomal Location of Human Ortholog: 7p13

Cellular Component: nucleoplasm; nucleus

Molecular Function: DNA-directed DNA polymerase activity; protein binding

Biological Process: bypass DNA synthesis; DNA damage response, detection of DNA damage; DNA replication; DNA strand elongation during DNA replication; mismatch repair; nucleotide-excision repair, DNA gap filling; nucleotide-excision repair, DNA incision; nucleotide-excision repair, DNA incision, 5'-to lesion; telomere maintenance; telomere maintenance via recombination; transcription-coupled nucleotide-excision repair