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POLDIP3 Blocking Peptide (N-Term) Blocking Peptide

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS9228824

Is involved in regulation of translation. Is preferentially associated with CBC-bound spliced mRNA-protein complexes during the pioneer round of mRNA translation. Contributes to enhanced translational efficiency of spliced over nonspliced mRNAs. Recruits… More details

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Product Overview

Online Datasheet in PDF
Product Name
POLDIP3, Blocking Peptide
Full Product Name
POLDIP3 Blocking Peptide (N-term)
Product Gene Name
POLDIP3 blocking peptide
Product Synonym Gene Name
KIAA1649; PDIP46
Product Synonym Names
Polymerase delta-interacting protein 3; 46 kDa DNA polymerase delta interaction protein; p46; S6K1 Aly/REF-like target; SKAR; POLDIP3; KIAA1649; PDIP46
Form/Format
Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
Specificity
The synthetic peptide sequence is selected from aa 108-120 of HUMAN POLDIP3
Preparation and Storage
Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.
Antibody/Peptide Pairs
POLDIP3 peptide (MBS9228824) is used for blocking the activity of POLDIP3 antibody (MBS9213858)
Molecular Weight
42,895 Da
OMIM
611520
Cellular Location
Nucleus. Nucleus speckle. Cytoplasm. Note: Nucleocytoplasmic shuttling protein

Other Notes

Small volumes of POLDIP3 blocking peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for POLDIP3 purchase

MBS9228824 is a blocking peptide targeting POLDIP3. Also known as POLDIP3 Blocking Peptide (N-term).

Additional Details

NCBI/Uniprot data below describe general gene information for POLDIP3. It may not necessarily be applicable to this product.

NCBI GI #
29837655
NCBI GeneID
84271
NCBI Accession #
NP_115687.2
UniProt Primary Accession #
Q9BY77
UniProt Secondary Accession #
Q009A7; Q5H972; Q6PGN6; Q7Z6Z0; Q9NSP5; Q9NSP6; A8K6F8; A8K6V9
UniProt Related Accession #
Q9BY77
GenBank Nucleotide #
NM_032311.4
NCBI Official Full Name
polymerase delta-interacting protein 3 isoform 1
NCBI Official Synonym Full Names
DNA polymerase delta interacting protein 3
NCBI Official Symbol
POLDIP3
NCBI Official Synonym Symbols
SKAR; PDIP46
UniProt Protein Name
Polymerase delta-interacting protein 3
UniProt Synonym Protein Names
46 kDa DNA polymerase delta interaction protein; p46; S6K1 Aly/REF-like target; SKAR
Protein Family
Polymerase delta-interacting protein
UniProt Gene Name
POLDIP3
UniProt Synonym Gene Names
KIAA1649; PDIP46; p46; SKAR
UniProt Entry Name
PDIP3_HUMAN
NCBI Protein Information
polymerase delta-interacting protein 3

NCBI Summary for POLDIP3

This gene encodes an RRM (RNA recognition motif)-containing protein that participates in the regulation of translation by recruiting ribosomal protein S6 kinase beta-1 to mRNAs. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

UniProt Comments for POLDIP3

SKAR: Is involved in regulation of translation. Is preferentially associated with CBC-bound spliced mRNA-protein complexes during the pioneer round of mRNA translation. Contributes to enhanced translational efficiency of spliced over nonspliced mRNAs. Recruits activated ribosomal protein S6 kinase beta-1 I/RPS6KB1 to newly synthesized mRNA. Interacts with POLD2. Interacts with NCBP1 and EIF4A3. Associates with the multiprotein exon junction complex (EJC). Interacts with RPS6KB1 (activated). Interacts with ERH. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: RNA-binding

Chromosomal Location of Human Ortholog: 22q13.2

Cellular Component: cytoplasm; cytosol; intracellular membrane-bound organelle; nuclear speck; nucleoplasm

Molecular Function: protein binding

Biological Process: mRNA 3'-end processing; mRNA export from nucleus; poly(A)+ mRNA export from nucleus; positive regulation of translation; RNA export from nucleus; termination of RNA polymerase II transcription
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Research Articles on POLDIP3

1. hnRNP-U inhibits TDP-43-mediated alterations in splicing of POLDIP3 mRNA.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with POLDIP3 blocking peptide

 Products by Pathway  Pathway Diagram
 Cleavage Of Growing Transcript In The Termination Region Pathway antibodies  Cleavage Of Growing Transcript In The Termination Region Pathway Diagram
 Gene Expression Pathway antibodies  Gene Expression Pathway Diagram
 Processing Of Capped Intron-Containing Pre-mRNA Pathway antibodies  Processing Of Capped Intron-Containing Pre-mRNA Pathway Diagram
 RNA Polymerase II Transcription Pathway antibodies  RNA Polymerase II Transcription Pathway Diagram
 RNA Polymerase II Transcription Termination Pathway antibodies  RNA Polymerase II Transcription Termination Pathway Diagram
 Transport Of Mature Transcript To Cytoplasm Pathway antibodies  Transport Of Mature Transcript To Cytoplasm Pathway Diagram
 Transport Of Mature MRNA Derived From An Intron-Containing Transcript Pathway antibodies  Transport Of Mature MRNA Derived From An Intron-Containing Transcript Pathway Diagram
 MRNA 3'-end Processing Pathway antibodies  MRNA 3'-end Processing Pathway Diagram
 MTOR Signaling Pathway antibodies  MTOR Signaling Pathway Diagram

Diseases associated with POLDIP3 blocking peptide

 Disease Name  Pubmed Publications
 Death Antibodies  >2 publications with POLDIP3 and Death
 Neoplasm Metastasis Antibodies  >1 publications with POLDIP3 and Neoplasm Metastasis
 Disease Models, Animal Antibodies  >1 publications with POLDIP3 and Disease Models, Animal
 Inflammation Antibodies  >1 publications with POLDIP3 and Inflammation
 Kidney Diseases Antibodies  >1 publications with POLDIP3 and Kidney Diseases

Organs/Tissues associated with POLDIP3 blocking peptide

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >4 publications with POLDIP3 and Brain
 Blood Antibodies  >3 publications with POLDIP3 and Blood
 Vascular Antibodies  >1 publications with POLDIP3 and Vascular
 Kidney Antibodies  >1 publications with POLDIP3 and Kidney
 Lung Antibodies  >1 publications with POLDIP3 and Lung
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