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POLR1E Antibody (Center) Blocking Peptide

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS9222267

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase I which synthesizes ribosomal RNA precursors. Appears to be involved in the formation of the… More details

$455 / 0.5 mg +1 FREE 8GB USB
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Testing Data View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
POLR1E, Blocking Peptide
Full Product Name
POLR1E Antibody (Center) Blocking Peptide
Product Gene Name
POLR1E blocking peptide
Product Synonym Gene Name
PAF53; PRAF1
Product Synonym Names
DNA-directed RNA polymerase I subunit RPA49; RNA polymerase I subunit A49; DNA-directed RNA polymerase I subunit E; RNA polymerase I-associated factor 1; RNA polymerase I-associated factor 53; POLR1E; PAF53; PRAF1
Form/Format
Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
Preparation and Storage
Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.
Antibody/Peptide Pairs
POLR1E peptide (MBS9222267) is used for blocking the activity of POLR1E antibody (MBS9207900)
Molecular Weight
47,260 Da
Cellular Location
Nucleus, nucleolus

Other Notes

Small volumes of POLR1E blocking peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for POLR1E purchase

MBS9222267 is a blocking peptide targeting POLR1E. Also known as POLR1E Antibody (Center) Blocking Peptide.

Additional Details

NCBI/Uniprot data below describe general gene information for POLR1E. It may not necessarily be applicable to this product.

NCBI GI #
62901107
NCBI GeneID
64425
NCBI Accession #
Q9GZS1.2
UniProt Primary Accession #
Q9GZS1
UniProt Secondary Accession #
Q5VZT3; Q8NBA9; Q96L20
UniProt Related Accession #
Q9GZS1
NCBI Official Full Name
DNA-directed RNA polymerase I subunit RPA49
NCBI Official Synonym Full Names
RNA polymerase I subunit E
NCBI Official Symbol
POLR1E
NCBI Official Synonym Symbols
PAF53; PRAF1
UniProt Protein Name
DNA-directed RNA polymerase I subunit RPA49
UniProt Synonym Protein Names
DNA-directed RNA polymerase I subunit E; RNA polymerase I-associated factor 1; RNA polymerase I-associated factor 53
UniProt Gene Name
POLR1E
UniProt Synonym Gene Names
PAF53; PRAF1; RNA polymerase I subunit A49
UniProt Entry Name
RPA49_HUMAN
NCBI Protein Information
DNA-directed RNA polymerase I subunit RPA49

UniProt Comments for POLR1E

POLR1E: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase I which synthesizes ribosomal RNA precursors. Appears to be involved in the formation of the initiation complex at the promoter by mediating the interaction between Pol I and UBTF/UBF. Belongs to the eukaryotic RPA49/POLR1E RNA polymerase subunit family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Nucleolus; Nucleotide Metabolism - pyrimidine; Nucleotide Metabolism - purine

Chromosomal Location of Human Ortholog: 9p13.2

Cellular Component: DNA-directed RNA polymerase I complex; nucleolus; nucleoplasm; nucleus

Biological Process: positive regulation of gene expression, epigenetic; RNA elongation from RNA polymerase I promoter; rRNA transcription; termination of RNA polymerase I transcription; transcription initiation from RNA polymerase I promoter
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Research Articles on POLR1E

1. Nucleolar detention requires binding of SIRT7 to nascent pre-rRNA, linking the spatial distribution of SIRT7 and deacetylation of PAF53 to ongoing transcription.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with POLR1E blocking peptide

 Products by Pathway  Pathway Diagram
 B-WICH Complex Positively Regulates RRNA Expression Pathway antibodies  B-WICH Complex Positively Regulates RRNA Expression Pathway Diagram
 Epigenetic Regulation Of Gene Expression Pathway antibodies  Epigenetic Regulation Of Gene Expression Pathway Diagram
 Eukaryotic Transcription Initiation Pathway antibodies  Eukaryotic Transcription Initiation Pathway Diagram
 Gene Expression Pathway antibodies  Gene Expression Pathway Diagram
 Metabolic Pathways antibodies  Metabolic Pathways Diagram
 Negative Epigenetic Regulation Of RRNA Expression Pathway antibodies  Negative Epigenetic Regulation Of RRNA Expression Pathway Diagram
 NoRC Negatively Regulates RRNA Expression Pathway antibodies  NoRC Negatively Regulates RRNA Expression Pathway Diagram
 Positive Epigenetic Regulation Of RRNA Expression Pathway antibodies  Positive Epigenetic Regulation Of RRNA Expression Pathway Diagram
 Purine Metabolism Pathway antibodies  Purine Metabolism Pathway Diagram
 Purine Metabolism Pathway antibodies  Purine Metabolism Pathway Diagram

Diseases associated with POLR1E blocking peptide

 Disease Name  Pubmed Publications
 Liver Neoplasms, Experimental Antibodies  >1 publications with POLR1E and Liver Neoplasms, Experimental
 Liver Neoplasms Antibodies  >1 publications with POLR1E and Liver Neoplasms
 Neoplasms, Experimental Antibodies  >1 publications with POLR1E and Neoplasms, Experimental
 Liver Diseases Antibodies  >1 publications with POLR1E and Liver Diseases
 Necrosis Antibodies  >1 publications with POLR1E and Necrosis

Organs/Tissues associated with POLR1E blocking peptide

 Organ/Tissue Name  Pubmed Publications
 Muscle Antibodies  >1 publications with POLR1E and Muscle
 Liver Antibodies  >1 publications with POLR1E and Liver
 Bladder Antibodies  >1 publications with POLR1E and Bladder
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