PPP3CA Blocking Peptide – Cat# MBS9625584

PPP3CA Blocking Peptide – The purity is >90%,tested by HPLC and MS. Purity

Name: PPP3CA Blocking Peptide; The purity is >90%,tested by HPLC and MS. Purity; MyBioSource
Brand: MyBioSource
SKU: MBS9625584
Price: 460 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS9625584

Blocking peptides are peptides that bind specifically to the target antibody and block antibody binding. These peptide usually contains the epitope recognized by the antibody. Antibodies bound to the blocking peptide no longer bind to the epitope on the… More details

$460 / 1 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

PPP3CA, Blocking Peptide

Full Product Name

PPP3CA Blocking Peptide

Product Gene Name

PPP3CA blocking peptide

Product Synonym Names

Alpha isoform formerly PPP2B; Calcineurin A alpha; Calcineurin A1; CalcineurinA; Calmodulin dependent calcineurin A subunit alpha isoform; Calmodulin-dependent calcineurin A subunit alpha isoform; CALN; CALNA 1; CALNA; CALNA1; CAM PRP catalytic subunit; CAM-PRP catalytic subunit; CCN 1; CCN1; CNA 1; CNA alpha; CNA; CNA1; PP2BA_HUMAN; PPP2B; Ppp3ca; Protein phosphatase 2B catalytic subunit; Protein phosphatase 3 (formerly 2B) catalytic subunit alpha isoform; Protein phosphatase 3 catalytic subunit alpha isoform PPP3CA; Protein phosphatase 3 catalytic subunit alpha isozyme; Serine/threonine protein phosphatase 2B catalytic subunit alpha isoform; Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform

Form/Format

Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 10 mg/ml.

Purity/Purification

The purity is >90%,tested by HPLC and MS.

Preparation and Storage

Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Antibody/Peptide Pairs

PPP3CA peptide (MBS9625584) is used for blocking the activity of PPP3CA antibody (MBS9606867)

Molecular Weight

51,245 Da

OMIM

114105

Supply Chain Verification

Manufactured in a lab with traceable raw materials manufactured on site. Coordinated product portfolio of antibodies, pairs, conjugates, recombinant proteins, and immunoassay materials available, please inquire.

Notes

For phospho antibody, we provide phospho peptide (0.5mg) and non-phospho peptide (0.5mg)

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Applications Tested/Suitable for PPP3CA blocking peptide

Blocking/Control

Other Notes

Small volumes of PPP3CA blocking peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for PPP3CA purchase

MBS9625584 is a blocking peptide targeting PPP3CA.

Additional Details

NCBI/Uniprot data below describe general gene information for PPP3CA. It may not necessarily be applicable to this product.

NCBI GI #

6715568

NCBI GeneID

5530

NCBI Accession #

NP_000935.1

UniProt Primary Accession #

Q08209

UniProt Secondary Accession #

Q8TAW9; A1A441; A8K3B7; A8W6Z7; A8W6Z8; B5BUA2

UniProt Related Accession #

Q08209

GenBank Nucleotide #

NM_000944.4

NCBI Official Full Name

serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform 1

NCBI Official Synonym Full Names

protein phosphatase 3, catalytic subunit, alpha isozyme

NCBI Official Symbol

PPP3CA

NCBI Official Synonym Symbols

CALN; CCN1; CNA1; CALNA; PPP2B; CALNA1

UniProt Protein Name

Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform

UniProt Synonym Protein Names

CAM-PRP catalytic subunit; Calmodulin-dependent calcineurin A subunit alpha isoform

Protein Family

Serine/threonine-protein phosphatase

UniProt Gene Name

PPP3CA

UniProt Synonym Gene Names

CALNA; CNA

UniProt Entry Name

PP2BA_HUMAN

NCBI Protein Information

serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform; CAM-PRP catalytic subunit; calcineurin A alpha; calmodulin-dependent calcineurin A subunit alpha isoform; protein phosphatase 2B, catalytic subunit, alpha isoform; protein phosphatas

UniProt Comments for PPP3CA

PPP3CA: a calmodulin-dependent Ser/Thr phosphatase also known calcineurin A alpha. Involved in a wide range of biologic activities, acting as a Ca(2 )-dependent modifier of phosphorylation status. Dephosphorylates HSPB1. The calcineurin holoenzyme is composed of catalytic and regulatory subunits of 60 and 18 kD, respectively. .

Protein type: Protein phosphatase, Ser/Thr (non-receptor); EC 3.1.3.16

Chromosomal Location of Human Ortholog: 4q24

Cellular Component: nucleoplasm; mitochondrion; cytoplasm; Z disc; cytosol; calcineurin complex; sarcolemma

Molecular Function: calmodulin binding; protein dimerization activity; protein binding; enzyme binding; calmodulin-dependent protein phosphatase activity; protein heterodimerization activity; protein serine/threonine phosphatase activity; drug binding; calcium ion binding

Biological Process: regulation of synaptic transmission; positive regulation of NFAT protein import into nucleus; T cell activation; response to amphetamine; skeletal muscle fiber development; protein amino acid dephosphorylation; negative regulation of insulin secretion; calcineurin-NFAT signaling pathway; transition between fast and slow fiber; dephosphorylation; protein import into nucleus; calcium ion transport; innate immune response; positive regulation of transcription from RNA polymerase II promoter; response to calcium ion; regulation of excitatory postsynaptic membrane potential; multicellular organismal response to stress; G1/S transition of mitotic cell cycle

Research Articles on PPP3CA

1. Human herpesvirus 6B U54 binds the calcineurin (CaN) phosphatase enzyme, causing improper dephosphorylation and nuclear translocation of NFAT (nuclear factor of activated T cells) proteins, resulting in suboptimal IL-2 gene transcription.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with PPP3CA blocking peptide

Reference Product	PubMed Publications
PPP3R1 blocking peptide	>7 publications with PPP3CA and PPP3R1
PPP2CB blocking peptide	>3 publications with PPP3CA and PPP2CB
PPP2CA blocking peptide	>3 publications with PPP3CA and PPP2CA
NFATC1 blocking peptide	>2 publications with PPP3CA and NFATC1

Pathways associated with PPP3CA blocking peptide

Products by Pathway	Pathway Diagram
Alzheimer's Disease Pathway antibodies	Alzheimer's Disease Pathway Diagram
Alzheimer's Disease Pathway antibodies	Alzheimer's Disease Pathway Diagram
Alzheimers Disease Pathway antibodies	Alzheimers Disease Pathway Diagram
Amphetamine Addiction Pathway antibodies	Amphetamine Addiction Pathway Diagram
Amphetamine Addiction Pathway antibodies	Amphetamine Addiction Pathway Diagram
Amyotrophic Lateral Sclerosis (ALS) Pathway antibodies	Amyotrophic Lateral Sclerosis (ALS) Pathway Diagram
Amyotrophic Lateral Sclerosis (ALS) Pathway antibodies	Amyotrophic Lateral Sclerosis (ALS) Pathway Diagram
Amyotrophic Lateral Sclerosis (ALS) Pathway antibodies	Amyotrophic Lateral Sclerosis (ALS) Pathway Diagram
Apoptosis Pathway antibodies	Apoptosis Pathway Diagram
Apoptosis Pathway antibodies	Apoptosis Pathway Diagram

Diseases associated with PPP3CA blocking peptide

Disease Name	Pubmed Publications
Nervous System Diseases Antibodies	>4 publications with PPP3CA and Nervous System Diseases
Brain Diseases Antibodies	>4 publications with PPP3CA and Brain Diseases
Hypertrophy Antibodies	>3 publications with PPP3CA and Hypertrophy
Carcinoma, Hepatocellular Antibodies	>3 publications with PPP3CA and Carcinoma, Hepatocellular
Inflammation Antibodies	>2 publications with PPP3CA and Inflammation
Hypertension Antibodies	>2 publications with PPP3CA and Hypertension
Liver Diseases Antibodies	>2 publications with PPP3CA and Liver Diseases
Kidney Diseases Antibodies	>1 publications with PPP3CA and Kidney Diseases
Liver Neoplasms Antibodies	>1 publications with PPP3CA and Liver Neoplasms
Edema Antibodies	>1 publications with PPP3CA and Edema

Organs/Tissues associated with PPP3CA blocking peptide

Organ/Tissue Name	Pubmed Publications
Muscle Antibodies	>10 publications with PPP3CA and Muscle
Blood Antibodies	>6 publications with PPP3CA and Blood
Brain Antibodies	>6 publications with PPP3CA and Brain
Heart Antibodies	>5 publications with PPP3CA and Heart
Vascular Antibodies	>4 publications with PPP3CA and Vascular
Kidney Antibodies	>2 publications with PPP3CA and Kidney
Bone Antibodies	>2 publications with PPP3CA and Bone
Liver Antibodies	>2 publications with PPP3CA and Liver
Eye Antibodies	>1 publications with PPP3CA and Eye
Mammary Gland Antibodies	>1 publications with PPP3CA and Mammary Gland