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PRDM14 Blocking Peptide (N-Term) Blocking Peptide

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS9229678

Transcription factor that has both positive and negative roles on transcription. Required for the maintenance of emryonic stem cell identity and the reacquisition of pluripotency in somatic cells. May play an essential role in germ cell development at 2… More details

$455 / 0.5 mg +1 FREE 8GB USB
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Testing Data View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
PRDM14, Blocking Peptide
Full Product Name
PRDM14 Blocking Peptide (N-term)
Product Gene Name
PRDM14 blocking peptide
Product Synonym Names
PR domain zinc finger protein 14; 211-; PR domain-containing protein 14; PRDM14
Form/Format
Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
Specificity
The synthetic peptide sequence is selected from aa 128-143 of HUMAN PRDM14
Preparation and Storage
Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.
Antibody/Peptide Pairs
PRDM14 peptide (MBS9229678) is used for blocking the activity of PRDM14 antibody (MBS9210837)
Molecular Weight
64,062 Da
OMIM
611781
Cellular Location
Nucleus.
Tissue Location
Expressed in embryonic stem cells. Tends to be overexpressed in breast cancer (at protein level)

Other Notes

Small volumes of PRDM14 blocking peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for PRDM14 purchase

MBS9229678 is a blocking peptide targeting PRDM14. Also known as PRDM14 Blocking Peptide (N-term).

Additional Details

NCBI/Uniprot data below describe general gene information for PRDM14. It may not necessarily be applicable to this product.

NCBI GI #
17368925
NCBI GeneID
63978
NCBI Accession #
Q9GZV8.1
UniProt Primary Accession #
Q9GZV8
UniProt Secondary Accession #
Q86UX9
UniProt Related Accession #
Q9GZV8
NCBI Official Full Name
PR domain zinc finger protein 14
NCBI Official Synonym Full Names
PR/SET domain 14
NCBI Official Symbol
PRDM14
NCBI Official Synonym Symbols
PFM11
UniProt Protein Name
PR domain zinc finger protein 14
UniProt Synonym Protein Names
PR domain-containing protein 14
Protein Family
PR domain zinc finger protein
UniProt Gene Name
PRDM14
UniProt Entry Name
PRD14_HUMAN
NCBI Protein Information
PR domain zinc finger protein 14

NCBI Summary for PRDM14

This gene encodes a member of the PRDI-BF1 and RIZ homology domain containing (PRDM) family of transcriptional regulators. The encoded protein may possess histone methyltransferase activity and plays a critical role in cell pluripotency by suppressing the expression of differentiation marker genes. Expression of this gene may play a role in breast cancer. [provided by RefSeq, Dec 2011]
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UniProt Comments for PRDM14

PRDM14: a probable protein lysine methyltransferase that works in concert with the core human embryonic stem cell (ESC) regulators to control pluripotency associated genes. Binds to silenced genes in human ESCs. Its binding profile is enriched for the repressive tri-methylation of histone H3 lysine 27 (H3K27me3) modification. Interacts directly with the polycomb repressive complex 2 (PRC2). PRC2 is detected at PRDM14-bound loci in human ESCs. A probable transcriptional regulator of the krueppel C2H2-type zinc-finger protein family. Has both positive and negative roles on transcription. Required for the maintenance of emryonic stem cell identity and the reacquisition of pluripotency in somatic cells. May play an essential role in germ cell development at 2 levels: the reacquisition of potential pluripotency, including SOX2 up-regulation, and successful epigenetic reprogramming. Directly up-regulates the expression of pluripotency gene POU5F1 through its proximal enhancer. Binds to the DNA consensus sequence 5'-GGTC[TC]CTAA-3'.

Protein type: C2H2-type zinc finger protein; Methyltransferase, protein arginine, predicted

Chromosomal Location of Human Ortholog: 8q13.3

Cellular Component: nucleoplasm

Molecular Function: protein binding

Biological Process: somatic stem cell maintenance
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Research Articles on PRDM14

1. In response to cytokines, pluripotent stem cells differentiate first into a heterogeneous mesoderm-like cell population and then into Primordial Germ cell-Like Cells, which exhibit minimal PRDM14 expression.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with PRDM14 blocking peptide

 Products by Pathway  Pathway Diagram
 Developmental Biology Pathway antibodies  Developmental Biology Pathway Diagram
 Transcriptional Regulation Of Pluripotent Stem Cells Pathway antibodies  Transcriptional Regulation Of Pluripotent Stem Cells Pathway Diagram

Diseases associated with PRDM14 blocking peptide

 Disease Name  Pubmed Publications
 Breast Neoplasms Antibodies  >7 publications with PRDM14 and Breast Neoplasms
 Lung Neoplasms Antibodies  >5 publications with PRDM14 and Lung Neoplasms
 Respiratory Tract Diseases Antibodies  >5 publications with PRDM14 and Respiratory Tract Diseases
 Cell Transformation, Neoplastic Antibodies  >4 publications with PRDM14 and Cell Transformation, Neoplastic
 Precursor Cell Lymphoblastic Leukemia-Lymphoma Antibodies  >3 publications with PRDM14 and Precursor Cell Lymphoblastic Leukemia-Lymphoma
 Fibrosis Antibodies  >1 publications with PRDM14 and Fibrosis
 Infertility, Male Antibodies  >1 publications with PRDM14 and Infertility, Male
 Testicular Diseases Antibodies  >1 publications with PRDM14 and Testicular Diseases
 Neoplasms, Experimental Antibodies  >1 publications with PRDM14 and Neoplasms, Experimental
 Inflammation Antibodies  >1 publications with PRDM14 and Inflammation

Organs/Tissues associated with PRDM14 blocking peptide

 Organ/Tissue Name  Pubmed Publications
 Embryonic Tissue Antibodies  >4 publications with PRDM14 and Embryonic Tissue
 Testis Antibodies  >2 publications with PRDM14 and Testis
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