PROX1: May play a fundamental role in early development of CNS. May regulate gene expression and development of postmitotic undifferentiated young neurons. Belongs to the Prospero homeobox family.
Protein type: DNA-binding; Transcription factor; Nuclear receptor co-regulator
Chromosomal Location of Human Ortholog: 1q41
Cellular Component: cytoplasm; nucleus
Molecular Function: RNA polymerase II transcription factor activity, enhancer binding; ligand-dependent nuclear receptor binding; protein binding; DBD domain binding; DNA binding; LBD domain binding; transcription factor activity; transcription corepressor activity
Biological Process: transcription from RNA polymerase II promoter; lens development in camera-type eye; circadian rhythm; neural tube development; positive regulation of cyclin-dependent protein kinase activity; ventricular cardiac myofibril development; muscle thin filament assembly; atrial cardiac muscle morphogenesis; positive regulation of transcription, DNA-dependent; cell fate determination; negative regulation of transcription from RNA polymerase II promoter; olfactory placode formation; negative regulation of cell proliferation; venous blood vessel morphogenesis; pancreas development; positive regulation of cell proliferation; lymphangiogenesis; ventricular cardiac muscle morphogenesis; kidney development; response to nutrient levels; dentate gyrus development; negative regulation of transcription factor activity; positive regulation of cell cycle; liver development; regulation of circadian rhythm; cerebellar granule cell differentiation; dorsal spinal cord development; negative regulation of viral genome replication; regulation of gene expression; otic placode formation; embryonic retina morphogenesis in camera-type eye; positive regulation of endothelial cell proliferation; optic placode formation involved in camera-type eye; positive regulation of transcription from RNA polymerase II promoter; brain development; negative regulation of transcription, DNA-dependent; retina morphogenesis in camera-type eye; lung development
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