Mouse Prr5 Antibody (C-Term) Blocking Peptide

PROTOR1: Subunit of mTORC2, which regulates cell growth and survival in response to hormonal signals. mTORC2 is activated by growth factors, but, in contrast to mTORC1, seems to be nutrient- insensitive. mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors. mTORC2 promotes the serum-induced formation of stress-fibers or F-actin. mTORC2 plays a critical role in AKT1 'Ser-473' phosphorylation, which may facilitate the phosphorylation of the activation loop of AKT1 on 'Thr-308' by PDK1 which is a prerequisite for full activation. mTORC2 regulates the phosphorylation of SGK1 at 'Ser-422'. mTORC2 also modulates the phosphorylation of PRKCA on 'Ser-657'. PRR5 plays an important role in regulation of PDGFRB expression and in modulation of platelet-derived growth factor signaling. May act as a tumor suppressor in breast cancer. Belongs to the PROTOR family. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Tumor suppressor

Cellular Component: TORC2 complex

Molecular Function: GTPase activator activity

Biological Process: actin cytoskeleton organization and biogenesis; positive regulation of cell migration; positive regulation of phosphoinositide 3-kinase cascade; positive regulation of protein amino acid phosphorylation