R Cdk4 Blocking Peptide (C-Term) Blocking Peptide

CDK4: a protein kinase of the CDK family that is important for cell cycle G1 phase progression. Its activity is restricted to the G1-S phase. Controlled by the regulatory subunits D-type cyclins and CDK inhibitor p16(INK4a). Phosphorylates the retinoblastoma gene product (Rb). Point mutations found in somatic and familial melanoma. Amplified in sarcomas, glioma and lymphoma. Amplified, methylated or deleted in head and neck squamous cell carcinoma. Overexpression drives epithelial tumors in mice. Disruption makes mice resistant to cancer. Inhibitor: PD332991.

Protein type: Protein kinase, Ser/Thr (non-receptor); Kinase, protein; Cell cycle regulation; EC 2.7.11.22; Protein kinase, CMGC; CMGC group; CDK family; CDK4 subfamily; CDK/CDK4 subfamily

Cellular Component: chromatin; cyclin-dependent protein kinase holoenzyme complex; cytosol; nuclear membrane; nucleolus; nucleus; perinuclear region of cytoplasm; tight junction; transcription factor complex

Molecular Function: cyclin binding; cyclin-dependent protein kinase activity; kinase activity; protein complex binding; protein kinase activity

Biological Process: circadian rhythm; G1/S transition of mitotic cell cycle; lens development in camera-type eye; organ regeneration; positive regulation of apoptosis; positive regulation of cell proliferation; positive regulation of cell size; positive regulation of fibroblast proliferation; positive regulation of translation; protein amino acid phosphorylation; regulation of cell cycle; regulation of cell proliferation; regulation of gene expression; response to drug; response to hyperoxia; response to lead ion; response to organic substance; response to testosterone stimulus; response to toxin; signal transduction