RAB21 Blocking Peptide – The purity is >90%,tested by HPLC and MS. Purity

This gene belongs to the Rab family of monomeric GTPases, which are involved in the control of cellular membrane traffic. The encoded protein plays a role in the targeted trafficking of integrins via its association with integrin alpha tails. As a consequence, the encoded protein is involved in the regulation of cell adhesion and migration. [provided by RefSeq, Aug 2013]

RAB21: Regulates integrin internalization and recycling, but does not influence the traffic of endosomally translocated receptors in general. As a result, may regulate cell adhesion and migration. During the mitosis of adherent cells, controls the endosomal trafficking of integrins which is required for the successful completion of cytokinesis. Belongs to the small GTPase superfamily. Rab family.

Protein type: G protein, monomeric; Motility/polarity/chemotaxis; G protein, monomeric, Rab

Chromosomal Location of Human Ortholog: 12q21.1

Cellular Component: endoplasmic reticulum membrane; internal side of plasma membrane; focal adhesion; cytoplasmic vesicle membrane; early endosome; vesicle membrane; trans-Golgi network; endosome; cleavage furrow

Molecular Function: GTPase activity; protein binding; GDP binding; GTP binding

Biological Process: regulation of exocytosis; intracellular protein transport; metabolic process; regulation of endocytosis; Rab protein signal transduction; positive regulation of receptor-mediated endocytosis