RGS2 Blocking Peptide – The purity is >90%,tested by HPLC and MS. Purity

Regulator of G protein signaling (RGS) family members are regulatory molecules that act as GTPase activating proteins (GAPs) for G alpha subunits of heterotrimeric G proteins. RGS proteins are able to deactivate G protein subunits of the Gi alpha, Go alpha and Gq alpha subtypes. They drive G proteins into their inactive GDP-bound forms. Regulator of G protein signaling 2 belongs to this family. The protein acts as a mediator of myeloid differentiation and may play a role in leukemogenesis. [provided by RefSeq, Aug 2009]

RGS2: Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. May play a role in leukemogenesis. Plays a role in negative feedback control pathway for adenylyl cyclase signaling. Binds EIF2B5 and blocks its activity, thereby inhibiting the translation of mRNA into protein. 4 isoforms of the human protein are produced by alternative initiation.

Protein type: Nucleolus; GAPs, misc.; GAPs

Chromosomal Location of Human Ortholog: 1q31

Cellular Component: internal side of plasma membrane; neuron projection; mitochondrion; cytoplasm; plasma membrane; nucleolus; cytosol

Molecular Function: calmodulin binding; protein binding; beta-tubulin binding; GTPase activator activity

Biological Process: regulation of translation; negative regulation of MAP kinase activity; relaxation of vascular smooth muscle; negative regulation of G-protein coupled receptor protein signaling pathway; positive regulation of microtubule polymerization; brown fat cell differentiation; spermatogenesis; cell cycle; regulation of G-protein coupled receptor protein signaling pathway; positive regulation of GTPase activity