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SENP1 Antibody (N-Term) Blocking Peptide

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS9219019

Protease that catalyzes two essential functions in the SUMO pathway: processing of full-length SUMO1, SUMO2 and SUMO3 to their mature forms and deconjugation of SUMO1, SUMO2 and SUMO3 from targeted proteins. Deconjugates SUMO1 from HIPK2. Deconjugates SUMO1… More details

$455 / 0.5 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
SENP1, Blocking Peptide
Full Product Name
SENP1 Antibody (N-term) Blocking Peptide
Product Gene Name
SENP1 blocking peptide
Product Synonym Names
Sentrin-specific protease 1; Sentrin/SUMO-specific protease SENP1; SENP1
Form/Format
The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.
Specificity
The synthetic peptide sequence used to generate the antibody was selected from the N-term region of human SENP1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Preparation and Storage
Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.
Antibody/Peptide Pairs
SENP1 peptide (MBS9219019) is used for blocking the activity of SENP1 antibody (MBS9202497)
Molecular Weight
73,351 Da
OMIM
612157
Cellular Location
Nucleus. Cytoplasm. Note: Shuttles between cytoplasm and nucleus
Tissue Location
Highly expressed in testis. Expressed at lower levels in thymus, pancreas, spleen, liver, ovary and small intestine.

Other Notes

Small volumes of SENP1 blocking peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for SENP1 purchase

MBS9219019 is a blocking peptide targeting SENP1. Also known as SENP1 Antibody (N-term) Blocking Peptide.

Additional Details

NCBI/Uniprot data below describe general gene information for SENP1. It may not necessarily be applicable to this product.

NCBI GI #
215273882
NCBI GeneID
29843
NCBI Accession #
Q9P0U3.2
UniProt Primary Accession #
Q9P0U3
UniProt Secondary Accession #
Q86XC8; A8K7P5
UniProt Related Accession #
Q9P0U3
NCBI Official Full Name
Sentrin-specific protease 1
NCBI Official Synonym Full Names
SUMO1/sentrin specific peptidase 1
NCBI Official Symbol
SENP1
NCBI Official Synonym Symbols
SuPr-2
UniProt Protein Name
Sentrin-specific protease 1
UniProt Synonym Protein Names
Sentrin/SUMO-specific protease SENP1
Protein Family
Sentrin-specific protease
UniProt Gene Name
SENP1
UniProt Entry Name
SENP1_HUMAN
NCBI Protein Information
sentrin-specific protease 1

NCBI Summary for SENP1

This gene encodes a cysteine protease that specifically targets members of the small ubiquitin-like modifier (SUMO) protein family. This protease regulates SUMO pathways by deconjugating sumoylated proteins. This protease also functions to process the precursor SUMO proteins into their mature form. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jun 2012]
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UniProt Comments for SENP1

SENP1: Protease that catalyzes two essential functions in the SUMO pathway: processing of full-length SUMO1, SUMO2 and SUMO3 to their mature forms and deconjugation of SUMO1, SUMO2 and SUMO3 from targeted proteins. Deconjugates SUMO1 from HIPK2. Deconjugates SUMO1 from HDAC1, which decreases its transcriptional repression activity. Belongs to the peptidase C48 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 3.4.22.68; Protease; Nuclear receptor co-regulator

Chromosomal Location of Human Ortholog: 12q13.1

Cellular Component: focal adhesion; nuclear membrane; nucleoplasm; nucleus

Molecular Function: endopeptidase activity; protein binding; SUMO-specific protease activity

Biological Process: caspase activation; positive regulation of transcription from RNA polymerase II promoter; protein desumoylation; protein sumoylation; proteolysis
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Research Articles on SENP1

1. SENP1 expression has strong prognostic impact in a molecularly defined subset of cancers. This is per se not surprising as the biologic impact of each individual molecular event is likely to be dependent on its cellular environment.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with SENP1 blocking peptide

 Reference Product  PubMed Publications
 SUMO1 blocking peptide  >116 publications with SENP1 and SUMO1
 SUMO2 blocking peptide  >23 publications with SENP1 and SUMO2
 SUMO3 blocking peptide  >13 publications with SENP1 and SUMO3
 RANGAP1 blocking peptide  >7 publications with SENP1 and RANGAP1
 GATA1 blocking peptide  >2 publications with SENP1 and GATA1
 HDAC1 blocking peptide  >2 publications with SENP1 and HDAC1
 BCL11B blocking peptide  >1 publications with SENP1 and BCL11B

Pathways associated with SENP1 blocking peptide

 Products by Pathway  Pathway Diagram
 Metabolism Of Proteins Pathway antibodies  Metabolism Of Proteins Pathway Diagram
 Post-translational Protein Modification Pathway antibodies  Post-translational Protein Modification Pathway Diagram
 Processing And Activation Of SUMO Pathway antibodies  Processing And Activation Of SUMO Pathway Diagram
 Regulation Of Androgen Receptor Activity Pathway antibodies  Regulation Of Androgen Receptor Activity Pathway Diagram
 SUMO Is Proteolytically Processed Pathway antibodies  SUMO Is Proteolytically Processed Pathway Diagram
 SUMOylation Pathway antibodies  SUMOylation Pathway Diagram

Diseases associated with SENP1 blocking peptide

 Disease Name  Pubmed Publications
 Inflammation Antibodies  >16 publications with SENP1 and Inflammation
 Prostatic Neoplasms Antibodies  >13 publications with SENP1 and Prostatic Neoplasms
 Cardiovascular Diseases Antibodies  >8 publications with SENP1 and Cardiovascular Diseases
 Cell Transformation, Neoplastic Antibodies  >5 publications with SENP1 and Cell Transformation, Neoplastic
 Neoplasm Metastasis Antibodies  >3 publications with SENP1 and Neoplasm Metastasis
 Disease Models, Animal Antibodies  >3 publications with SENP1 and Disease Models, Animal
 Hypertension Antibodies  >3 publications with SENP1 and Hypertension
 Neoplasms, Experimental Antibodies  >2 publications with SENP1 and Neoplasms, Experimental
 Liver Neoplasms Antibodies  >2 publications with SENP1 and Liver Neoplasms
 Liver Diseases Antibodies  >2 publications with SENP1 and Liver Diseases

Organs/Tissues associated with SENP1 blocking peptide

 Organ/Tissue Name  Pubmed Publications
 Prostate Antibodies  >20 publications with SENP1 and Prostate
 Blood Antibodies  >13 publications with SENP1 and Blood
 Brain Antibodies  >11 publications with SENP1 and Brain
 Vascular Antibodies  >10 publications with SENP1 and Vascular
 Pancreas Antibodies  >8 publications with SENP1 and Pancreas
 Lung Antibodies  >8 publications with SENP1 and Lung
 Kidney Antibodies  >6 publications with SENP1 and Kidney
 Lymph Node Antibodies  >5 publications with SENP1 and Lymph Node
 Liver Antibodies  >5 publications with SENP1 and Liver
 Muscle Antibodies  >4 publications with SENP1 and Muscle
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